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Epidemiological characterization of Plasmodium falciparum in the Republic of Cabo Verde

2006-04-21Artigo científico Acesso aberto
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dc.contributor.authorAlves, Joana
dc.contributor.authorRoque, Ana Luísa
dc.contributor.authorCravo, Pedro
dc.contributor.authorValdez, Tomás
dc.contributor.authorJelinek, Tomas
dc.contributor.authorRosário, Virgilio Estólio do
dc.contributor.authorArez, Ana Paula
dc.contributor.institutionInstituto de Higiene e Medicina Tropical (IHMT)
dc.contributor.institutionCentro de Malária e outras Doenças Tropicais (CMDT)
dc.contributor.pblBioMed Central (BMC)
dc.date.accessioned2021-05-06T22:39:52Z
dc.date.available2021-05-06T22:39:52Z
dc.date.issued2006-04-21
dc.description.abstractBackground: Malaria has come near eradication at archipelago of Cabo Verde in 1970. Infections are now only observed in Santiago, where outbreaks occur. In these islands, malaria is considered by the international community as being of limited risk and, therefore, no prophylaxis is recommended. Since the understanding of factors that determine malaria outbreaks are crucial for controlling the disease, the present study aimed to investigate if the malaria infections observed in Santiago Island are maintained in isolated foci and in asymptomatic individuals. Methods: The occurrence of asymptomatic carriers in villages with history of malaria as well as the level of exposure of these populations were investigated using PCR and serological analyses. Results: Results indicate that malaria is maintained as asymptomatic and sub-patent infections and that the majority of the circulating parasite populations harbour chloroquine-resistant mutations. Conclusion: These observations highlight the alarming prospect of malaria to become a serious public health problem and underscore the need for a tighter surveillance.en
dc.description.versionpublishersversion
dc.description.versionpublished
dc.format.extent8
dc.format.extent551715
dc.identifier.doi10.1186/1475-2875-5-32
dc.identifier.otherPURE: 2403280
dc.identifier.otherPURE UUID: 92639829-8fce-4ff3-8561-a647e02f0632
dc.identifier.otherScopus: 33845914309
dc.identifier.otherPubMed: 16630349
dc.identifier.otherORCID: /0000-0003-1675-4504/work/69154215
dc.identifier.otherORCID: /0000-0002-0497-6532/work/74243193
dc.identifier.otherPubMedCentral: PMC1464146
dc.identifier.otherWOS: 000238268700001
dc.identifier.urihttp://hdl.handle.net/10362/117214
dc.identifier.urlhttps://www.scopus.com/pages/publications/33845914309
dc.identifier.urlhttps://malariajournal.biomedcentral.com/articles/10.1186/1475-2875-5-32
dc.language.isoeng
dc.peerreviewedyes
dc.subjectrisk factor
dc.subjectserology
dc.subjectadolescent
dc.subjectadult
dc.subjectaged
dc.subjectarticle
dc.subjectchild
dc.subjectcontrolled study
dc.subjectdisease control
dc.subjectenvironmental exposure
dc.subjectexposure variable
dc.subjecthuman
dc.subjectinfant
dc.subjectmajor clinical study
dc.subjectmalaria
dc.subjectPlasmodium falciparum
dc.subjectpolymerase chain reaction
dc.subjectpublic health
dc.subjectEpidemiology
dc.subjectInfectious Diseases
dc.subjectParasitology
dc.subjectSDG 3 - Good Health and Well-being
dc.titleEpidemiological characterization of Plasmodium falciparum in the Republic of Cabo Verdeen
dc.title.subtitleimplications for potential large-scale re-emergence of malariaen
dc.typejournal article
degois.publication.titleMalaria Journal
degois.publication.volume5
dspace.entity.typePublication
rcaap.rightsopenAccess

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