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Endovascular treatment for isolated cervical internal carotid artery occlusion

2025-09Artigo científico Acesso aberto
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dc.contributor.authorMarto, João Pedro
dc.contributor.authorRiegler, Christoph
dc.contributor.authorGebert, Pimrapat
dc.contributor.authorReiff, Tilman
dc.contributor.authorSykora, Marek
dc.contributor.authorWiącek, Marcin
dc.contributor.authorPakizer, David
dc.contributor.authorAraújo, André
dc.contributor.authorter Schiphorst, Adrien
dc.contributor.authorSousa, João André
dc.contributor.authorReich, Arno
dc.contributor.authorPina, Belen Flores
dc.contributor.authorMayer-Suess, Lukas
dc.contributor.authorHobeanu, Cristina
dc.contributor.authorZedde, Marialuisa
dc.contributor.authorRamos, João Nuno
dc.contributor.authorTsivgoulis, Georgios
dc.contributor.authorCastro, Pedro
dc.contributor.authorPoli, Sven
dc.contributor.authorAlves, José Nuno
dc.contributor.authorDusart, Anne
dc.contributor.authorFuentes, Blanca
dc.contributor.authorTejada Meza, Herbert
dc.contributor.authorDemeestere, Jelle
dc.contributor.authorWegener, Susanne
dc.contributor.authorKellert, Lars
dc.contributor.authorCalleja, Patricia
dc.contributor.authorPanea, Cristina
dc.contributor.authorVollmuth, Christoph
dc.contributor.authorPereira, Liliana
dc.contributor.authorLeker, Ronen R.
dc.contributor.authorUphaus, Timo
dc.contributor.authorZini, Andrea
dc.contributor.authorGensicke, Henrik
dc.contributor.authorDuloquin, Gauthier
dc.contributor.authorEbrahimi, Taraneh
dc.contributor.authorSalerno, Alexander
dc.contributor.authorTiu, Cristina
dc.contributor.authorNguyen, Thanh N.
dc.contributor.authorGarcía-Madrona, Sebastian
dc.contributor.authorBilik, Marta
dc.contributor.authorYaghi, Shadi
dc.contributor.authorSienkiewicz-Jarosz, Halina
dc.contributor.authorKarliński, Michał
dc.contributor.authorKrebs, Stefan
dc.contributor.authorHurtíková, Eva
dc.contributor.authorFerreira, Nathalia
dc.contributor.authorSargento-Freitas, João
dc.contributor.authorPinho, João
dc.contributor.authorCaamaño, Isabel Rodriguez
dc.contributor.authorGizewski, Elke Ruth
dc.contributor.authorSeners, Pierre
dc.contributor.authorPascarella, Rosario
dc.contributor.authorPsychogios, Klearchos
dc.contributor.authorGomez Exposito, Alexandra
dc.contributor.authorGomes, Sara
dc.contributor.authorBellante, Flavio
dc.contributor.authorRodríguez-Pardo, Jorge
dc.contributor.authorBautista Lacambra, Mario
dc.contributor.authorLemmens, Robin
dc.contributor.authorInauen, Corinne
dc.contributor.authorWischmann, Johannes
dc.contributor.authorOstos, Fernando
dc.contributor.authorTiu, Vlad
dc.contributor.authorHaeusler, Karl Georg
dc.contributor.authorRodrigues, Miguel
dc.contributor.authorMetanis, Issa
dc.contributor.authorHahn, Marianne
dc.contributor.authorViola, Maria Maddalena
dc.contributor.authorTruessel, Simon
dc.contributor.authorBejot, Yannick
dc.contributor.authorNitsch, Louisa
dc.contributor.authorStrambo, Davide
dc.contributor.authorTerecoasa, Elena Oana
dc.contributor.authorAbdalkader, Mohamad
dc.contributor.authorde Felipe, Alicia
dc.contributor.authorKhan, Farhan
dc.contributor.authorArquizan, Caroline
dc.contributor.authorRibeiro, Manuel
dc.contributor.authorRoubec, Martin
dc.contributor.authorTomaszewska-Lampart, Izabella
dc.contributor.authorFerrari, Julia
dc.contributor.authorRingleb, Peter
dc.contributor.authorNolte, Christian H.
dc.contributor.institutionNOVA Medical School|Faculdade de Ciências Médicas (NMS|FCM)
dc.contributor.pblSAGE Publications
dc.date.accessioned2025-04-10T16:00:03Z
dc.date.available2025-04-10T16:00:03Z
dc.date.issued2025-09
dc.descriptionPublisher Copyright: © European Stroke Organisation 2025.
dc.description.abstractIntroduction: Evidence regarding the benefit of endovascular therapy (EVT) in patients with acute ischemic stroke (AIS) due to isolated cervical internal carotid artery occlusion (c-ICA-O) is lacking. We assessed the outcomes and safety of EVT in patients with isolated c-ICA-O. Methods: Retrospective multicenter cohort study of patients with an AIS due to isolated c-ICA-O, within 24-h since last-seen-well. Comparisons were made between EVT and best medical therapy (BMT). The primary outcome was 3-months modified Rankin Scale (mRS) ordinal shift. Secondary outcomes included 3-month favorable outcome (mRS 0–2, or return to pre-stroke mRS), symptomatic intracranial hemorrhage (sICH) and any parenchymal hemorrhage. Outcomes were compared combining inverse probability of treatment weighting with regression models and propensity score matching (PSM) as sensitivity analysis. Results: We analyzed 998 patients (66.2% male, mean age 71.1 ± 13.2 years). 487 (48.8%) patients received EVT and 511 (51.2%) received BMT. Patients receiving EVT had a higher admission NIHSS [13 (7–18) vs 5 (2–13)] compared to BMT. There was no difference between EVT and BMT groups in 3-month mRS shift (adjusted common odds ratio [OR], 1.01 [95% CI 0.76–1.34]) and favorable outcome (adjusted OR [aOR] 1.16 [95% CI 0.84–1.60]). No patient (0%) in the BMT group had sICH versus 1.6% in the EVT group. Parenchymal hemorrhage was numerically higher in EVT patients (2.7% vs 0.6%; aOR 3.85 [95% CI 0.98–15.23]). PSM analysis revealed similar results. Discussion and conclusion: In patients with isolated c-ICA-O, EVT was associated with similar odds of disability and intracranial bleeding compared to BMT. Randomized-controlled clinical trials in patients with isolated c-ICA-O are warranted.en
dc.description.versionpublishersversion
dc.description.versionpublished
dc.format.extent1532633
dc.identifier.doi10.1177/23969873251323488
dc.identifier.issn2396-9873
dc.identifier.otherPURE: 114110732
dc.identifier.otherPURE UUID: f821e145-7d4f-4dd8-b231-f1e8c0dec579
dc.identifier.otherScopus: 86000714773
dc.identifier.otherPubMed: 40017435
dc.identifier.urihttp://hdl.handle.net/10362/182068
dc.identifier.urlhttps://www.scopus.com/pages/publications/86000714773
dc.language.isoeng
dc.peerreviewedyes
dc.subjectcervical carotid
dc.subjectEndovascular treatment
dc.subjectinternal carotid artery
dc.subjectmechanical thrombectomy
dc.subjectocclusion
dc.subjectoutcome
dc.subjectClinical Neurology
dc.subjectCardiology and Cardiovascular Medicine
dc.titleEndovascular treatment for isolated cervical internal carotid artery occlusionen
dc.title.subtitleETIICA studyen
dc.typejournal article
degois.publication.firstPage694
degois.publication.issue3
degois.publication.lastPage704
degois.publication.titleEuropean Stroke Journal
degois.publication.volume10
dspace.entity.typePublication
rcaap.rightsopenAccess

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