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Participation in clinical trials increases the detection of pre-malignant lesions during colonoscopy

2022-06-01Artigo científico Acesso aberto
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dc.contributor.authorFerreira, Alexandre Oliveira
dc.contributor.authorCosta-Santos, Maria Pia
dc.contributor.authorGomes, Catarina
dc.contributor.authorMorão, Bárbara
dc.contributor.authorGlória, Luisa
dc.contributor.authorCravo, Marília
dc.contributor.authorDinis-Ribeiro, Mário
dc.contributor.authorCanena, Jorge
dc.contributor.authorCanena, Jorge
dc.contributor.institutionNOVA Medical School|Faculdade de Ciências Médicas (NMS|FCM)
dc.contributor.pblEditorial Garsi / The Spanish Society of Digestive Pathology
dc.date.accessioned2023-02-16T22:20:31Z
dc.date.available2023-02-16T22:20:31Z
dc.date.issued2022-06-01
dc.description.abstractBACKGROUND: colorectal adenoma detection has been associated with the effectiveness of cancer prevention. Clinical trials have been designed to determine the role of several interventions to increase the detection of pre-malignant lesions. We hypothesized that colonoscopy in the setting of clinical trials has a higher pre-malignant lesion detection rate. METHODS: a cross-sectional study was performed that compared the detection of pre-malignant lesions in 147 randomly sampled non-research colonoscopies and 294 from the control group of two prospective trials. Outpatients aged 40-79 years, with no personal history of colorectal cancer (CRC) were included. RESULTS: baseline characteristics were similar between the two groups. The pre-malignant lesion detection rate in the trial vs control group was 65.6 % vs 44.2 % (OR 2.411; 95 % CI: 1.608-3.614; p < 0.001), the polyp detection rate was 73.8 % vs 59.9 % (OR 1.889; 95 % CI: 1.242-2.876; p = 0.003), the adenoma detection rate was 62.6 % vs 44.2 % (OR 2.110; 95 % CI: 1.411-3.155; p < 0.001) and the sessile serrated lesion detection rate was 17 % vs 4.1 % (OR 4.816; 95 % CI: 2.014-11.515; p < 0.001). The mean number of pre-malignant and sessile serrated lesions was 1.70 vs 1.06 (p = 0.002) and 0.32 vs 0.06 (p = 0.001) lesions per colonoscopy, respectively. There was no significant change in any of the study outcomes according to the multivariate analysis with each single potential confounder. CONCLUSIONS: patients involved in colonoscopy trials may benefit from higher quality examinations, as shown by the higher detection rates. Institutions should consider supporting clinical research in colonoscopy as a simple means to improve colonoscopy quality and colorectal cancer prevention.en
dc.description.versionpublishersversion
dc.description.versionpublished
dc.format.extent6
dc.format.extent592647
dc.identifier.doi10.17235/reed.2021.8104/2021
dc.identifier.issn1130-0108
dc.identifier.otherPURE: 44981206
dc.identifier.otherPURE UUID: 40286f0a-7cdc-4e04-9042-c60935169595
dc.identifier.otherScopus: 85131903627
dc.identifier.otherPubMed: 34607445
dc.identifier.otherWOS: 000813956100005
dc.identifier.urihttp://hdl.handle.net/10362/149343
dc.identifier.urlhttps://www.scopus.com/pages/publications/85131903627
dc.language.isoeng
dc.peerreviewedyes
dc.subjectGastroenterology
dc.subjectSDG 3 - Good Health and Well-being
dc.titleParticipation in clinical trials increases the detection of pre-malignant lesions during colonoscopyen
dc.typejournal article
degois.publication.firstPage323
degois.publication.issue6
degois.publication.lastPage328
degois.publication.titleRevista espanola de enfermedades digestivas : organo oficial de la Sociedad Espanola de Patologia Digestiva
degois.publication.volume114
dspace.entity.typePublication
person.familyNameCanena
person.givenNameJorge
person.identifier.orcid0000-0002-2539-5876
person.identifier.ridI-1379-2015
person.identifier.scopus-author-id6507619160
rcaap.rightsopenAccess
relation.isAuthorOfPublicationc8b48309-6089-430b-834c-46b5f79108bc
relation.isAuthorOfPublication.latestForDiscoveryc8b48309-6089-430b-834c-46b5f79108bc

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