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Enhancing Veliparib PARP1 inhibitor stability against UVC degradation via DPPG liposome encapsulation

2026Artigo científico Acesso aberto
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dc.contributor.authorConceição, Carlota J. F.
dc.contributor.authorMoe, Elin
dc.contributor.authorRibeiro, Paulo A.
dc.contributor.authorRaposo, Maria
dc.contributor.institutionDF – Departamento de Física
dc.contributor.institutionInstituto de Tecnologia Química e Biológica António Xavier (ITQB)
dc.contributor.institutionLIBPhys-UNL
dc.contributor.institutionLaboratório Associado de Translacção e Inovação para a Saúde Global - LA Real (Pólo FCT)
dc.contributor.pblRSC - Royal Society of Chemistry
dc.date.accessioned2026-05-22T15:28:01Z
dc.date.available2026-05-22T15:28:01Z
dc.date.issued2026
dc.descriptionPublisher Copyright: This journal is © The Royal Society of Chemistry, 2026
dc.description.abstractPoly(ADP-ribose) polymerase inhibitors (PARPi) are often used in complementary cancer therapy with radiotherapy and chemotherapy, but present some limitations that encapsulation may circumvent. Since conventional PARPi therapy was proven to increase cell sensitization to UV irradiation, and a shower of particles or radiation with energies equal to or below UV can be created during radiotherapy treatments, this work evaluates the effect of UVC on the degradation process and inhibitory capability of Veliparib encapsulated in 1,2-dipalmitoyl-sn-glycero-3-phospho-rac-(1′-glycerol) sodium salt (DPPG) liposomes, as well as identifies potential degradation products. Results demonstrate that Veliparib is sensitive to UVC radiation, leading to the degradation of the benzamide ring and carbonyl functional group. This coincides with Veliparib's inhibitory capability loss in PARP1's automodification activity. Furthermore, DPPG encapsulation was shown to protect Veliparib from UVC irradiation until 30 min of exposure. This was translated into a delay in the appearance of a degradation band at 330 nm. Infrared analysis revealed that this band is associated with the degradation of the benzamide ring and the carbonyl functional group. The latter presents several C 00000000 00000000 00000000 00000000 11111111 00000000 11111111 00000000 00000000 00000000 O infrared vibrational bands associated with isomerization and degradation of the functional group. The results allowed us to infer the potential degradation process of Veliparib due to UVC irradiation, which is associated with linear unsaturated aldehyde and conjugated ketone structures that arise from the degradation of the benzamide pharmacophore.en
dc.description.versionpublishersversion
dc.description.versionpublished
dc.format.extent12
dc.format.extent1798479
dc.identifier.doi10.1039/d5ra02652k
dc.identifier.issn2046-2069
dc.identifier.otherPURE: 162750070
dc.identifier.otherPURE UUID: 2ec99e02-3901-455a-a28e-f4877e0544de
dc.identifier.otherScopus: 105032998861
dc.identifier.otherWOS: 001716855700001
dc.identifier.otherPubMed: 41853208
dc.identifier.otherPubMedCentral: PMC12994379
dc.identifier.urihttp://hdl.handle.net/10362/203338
dc.identifier.urlhttps://www.scopus.com/pages/publications/105032998861
dc.identifier.urlhttps://www.webofscience.com/wos/woscc/full-record/WOS:001716855700001
dc.language.isoeng
dc.peerreviewedyes
dc.subjectGeneral Chemistry
dc.subjectGeneral Chemical Engineering
dc.subjectSDG 3 - Good Health and Well-being
dc.titleEnhancing Veliparib PARP1 inhibitor stability against UVC degradation via DPPG liposome encapsulationen
dc.typejournal article
degois.publication.firstPage14676
degois.publication.issue16
degois.publication.lastPage14687
degois.publication.titleRSC Advances
dspace.entity.typePublication
rcaap.rightsopenAccess

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