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Drug Delivery from PCL/Chitosan Multilayer Coatings for Metallic Implants

2022-07-12Artigo científico Acesso aberto
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dc.contributor.authorSoares, I.
dc.contributor.authorFaria, Jaime Moreira Machado
dc.contributor.authorMarques, A. C.
dc.contributor.authorRibeiro, Isabel A. C.
dc.contributor.authorBaleizão, Carlos
dc.contributor.authorBettencourt, Ana F.
dc.contributor.authorFerreira, Isabel
dc.contributor.authorBaptista, Ana Catarina
dc.contributor.institutionDCM - Departamento de Ciência dos Materiais
dc.contributor.institutionCENIMAT-i3N - Centro de Investigação de Materiais (Lab. Associado I3N)
dc.contributor.pblACS - American Chemical Society
dc.date.accessioned2022-08-23T22:18:55Z
dc.date.available2022-08-23T22:18:55Z
dc.date.issued2022-07-12
dc.descriptionThis work was partially funded by the FEDER funds through the COMPETE 2020 Program and National Funds through the FCT – Portuguese Foundation for Science and Technology under the projects UIDB/50025/2020-2023 (CENIMAT/I3N), and also partially supported by the project ERC-CoG-2014. The authors would like to thank the use of the traction machine at the Biomaterials Laboratory from the Soft and Bio-functional Materials Group (CENIMAT/I3N).
dc.description.abstractImplant-related infections, mainly caused by Staphylococcus aureus, are a major health concern. Treatment is challenging due to multi-resistant strains and the ability of S. aureus to adhere and form biofilms on bone and implant surfaces. The present work involved the preparation and evaluation of a novel dual polymeric film coating on stainless steel. Chitosan and polycaprolactone (PCL) multilayers, loaded with poly(methyl methacrylate) (PMMA) microspheres encapsulating vancomycin or daptomycin, produced by the dip-coating technique, allowed local antibiotic-controlled delivery for the treatment of implant-related infections. Enhanced adhesion of the film to the metal substrate surface was achieved by mechanical abrasion of its surface. Studies have shown that for both drugs the release occurs by diffusion, but the release profile depends on the type of drug (daptomycin or vancomycin), the pH of the solution, and whether the drug is freestanding (directly incorporated into the films) or encapsulated in PMMA microspheres. Daptomycin freestanding films reached 90% release after 1 day at pH 7.4 and 4 days at pH 5.5. In comparison, films with daptomycin encapsulated microspheres reached 90% release after 2 h at pH 5.5 and 2 days at pH 7.4. Vancomycin encapsulated and freestanding films showed a similar behavior reaching 90% release after 20 h of release at pH 5.5 and 2 and 3 days, respectively, at pH 7.4. Furthermore, daptomycin-loaded films showed activity (assessed by agar diffusion assays) against sensitive (ATCC 25923) and clinically isolated (MRSA) S. aureus strains.en
dc.description.versionpublishersversion
dc.description.versionpublished
dc.format.extent11
dc.format.extent9567662
dc.identifier.doi10.1021/acsomega.2c00504
dc.identifier.issn2470-1343
dc.identifier.otherPURE: 45126245
dc.identifier.otherPURE UUID: 55edf681-5d2c-4a17-8717-927a164b1567
dc.identifier.otherScopus: 85135092488
dc.identifier.otherWOS: 000822481600001
dc.identifier.otherPubMed: 35847270
dc.identifier.otherPubMedCentral: PMC9280759
dc.identifier.otherORCID: /0000-0002-8838-0364/work/117746892
dc.identifier.otherORCID: /0000-0003-1631-6248/work/117747489
dc.identifier.urihttp://hdl.handle.net/10362/143209
dc.identifier.urlhttps://www.scopus.com/pages/publications/85135092488
dc.language.isoeng
dc.peerreviewedyes
dc.relationinfo:eu-repo/grantAgreement/FCT/3599-PPCDT/PTDC%2FBTM-SAL%2F29335%2F2017/PT
dc.relationAntiBiofilm features of Glycolipid-functionalized Silicone Catheters towards Healthcare-associated infections prevention
dc.relationResearch Institute for Medicines
dc.relationResearch Institute for Medicines
dc.relationCentro de Química Estrutural
dc.relationCentro de Química Estrutural
dc.relationAll-Fibre Integrated Photovoltaic Storage Device for e-Textiles
dc.relationIntegration of Capacitor, Thermoelectric and PhotoVoltaic thin films for efficient energy conversion and storage
dc.relationPolymer-based multifunctional implant coatings to overcome biofilm-mediated infections.
dc.relationinfo:eu-repo/grantAgreement/FCT/3599-PPCDT/PTDC%2FCTM-CTM%2F1571%2F2020/PT
dc.relationinfo:eu-repo/grantAgreement/EC/H2020/647596/EU
dc.relationinfo:eu-repo/grantAgreement/FCT/OE/PD%2FBD%2F143032%2F2018/PT
dc.subjectGeneral Chemistry
dc.subjectGeneral Chemical Engineering
dc.subjectSDG 3 - Good Health and Well-being
dc.titleDrug Delivery from PCL/Chitosan Multilayer Coatings for Metallic Implantsen
dc.typejournal article
degois.publication.firstPage23096
degois.publication.issue27
degois.publication.lastPage23106
degois.publication.titleACS Omega
degois.publication.volume7
dspace.entity.typePublication
oaire.awardNumberPTDC/BTM-SAL/29335/2017
oaire.awardNumberUIDB/04138/2020
oaire.awardNumberUIDP/04138/2020
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oaire.awardNumberUIDP/00100/2020
oaire.awardNumberPTDC/CTM-CTM/1571/2020
oaire.awardNumber647596
oaire.awardNumberPD/BD/143032/2018
oaire.awardTitleAntiBiofilm features of Glycolipid-functionalized Silicone Catheters towards Healthcare-associated infections prevention
oaire.awardTitleResearch Institute for Medicines
oaire.awardTitleResearch Institute for Medicines
oaire.awardTitleCentro de Química Estrutural
oaire.awardTitleCentro de Química Estrutural
oaire.awardTitleAll-Fibre Integrated Photovoltaic Storage Device for e-Textiles
oaire.awardTitleIntegration of Capacitor, Thermoelectric and PhotoVoltaic thin films for efficient energy conversion and storage
oaire.awardTitlePolymer-based multifunctional implant coatings to overcome biofilm-mediated infections.
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/3599-PPCDT/PTDC%2FBTM-SAL%2F29335%2F2017/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/UIDB%2F04138%2F2020/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/UIDP%2F04138%2F2020/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/UIDB%2F00100%2F2020/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/UIDP%2F00100%2F2020/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/3599-PPCDT/PTDC%2FCTM-CTM%2F1571%2F2020/PT
oaire.awardURIinfo:eu-repo/grantAgreement/EC/H2020/647596/EU
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/OE/PD%2FBD%2F143032%2F2018/PT
oaire.fundingStream3599-PPCDT
oaire.fundingStream6817 - DCRRNI ID
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oaire.fundingStream6817 - DCRRNI ID
oaire.fundingStream3599-PPCDT
oaire.fundingStreamH2020
oaire.fundingStreamOE
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