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The architecture of the 10-23 DNAzyme and its implications for DNA-mediated catalysis

2022-12-07Artigo científico Acesso aberto
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dc.contributor.authorBorggräfe, Jan
dc.contributor.authorGertzen, Christoph G. W.
dc.contributor.authorViegas, Aldino
dc.contributor.authorGohlke, Holger
dc.contributor.authorEtzkorn, Manuel
dc.contributor.institutionUCIBIO - Applied Molecular Biosciences Unit
dc.contributor.institutionDQ - Departamento de Química
dc.contributor.pblFederation of European Biochemical Societies | Wiley
dc.date.accessioned2023-02-15T22:22:30Z
dc.date.available2023-02-15T22:22:30Z
dc.date.issued2022-12-07
dc.descriptionPublisher Copyright: © 2022 The Authors. The FEBS Journal published by John Wiley & Sons Ltd on behalf of Federation of European Biochemical Societies.
dc.description.abstractUnderstanding the molecular features of catalytically active DNA sequences, so-called DNAzymes, is essential not only for our understanding of the fundamental properties of catalytic nucleic acids in general, but may well be the key to unravelling their full potential via tailored modifications. Our recent findings contributed to the endeavour to assemble a mechanistic picture of DNA-mediated catalysis by providing high-resolution structural insights into the 10-23 DNAzyme (Dz) and exposing a complex interplay between the Dz's unique molecular architecture, conformational plasticity, and dynamic modulation by metal ions as central elements of the DNA catalyst. Here, we discuss key features of our findings and compare them to other studies on similar systems.en
dc.description.versionpublishersversion
dc.description.versionpublished
dc.format.extent11
dc.format.extent1838241
dc.identifier.doi10.1111/febs.16698
dc.identifier.issn1742-464X
dc.identifier.otherPURE: 53380850
dc.identifier.otherPURE UUID: db7b42d8-9ccd-4757-aebd-baaaf0452a5e
dc.identifier.otherScopus: 85144224693
dc.identifier.otherPubMed: 36478072
dc.identifier.otherWOS: 000899460700001
dc.identifier.urihttp://hdl.handle.net/10362/149299
dc.identifier.urlhttps://www.scopus.com/pages/publications/85144224693
dc.language.isoeng
dc.peerreviewedyes
dc.relationinfo:eu-repo/grantAgreement/EC/H2020/660258/EU
dc.relationEpidermal growth factor receptor (EGFR) activation by cytohesins - Structural Insights
dc.subject10-23 DNAzyme
dc.subjectDNAzymes
dc.subjectMD
dc.subjectNMR
dc.subjectBiochemistry
dc.subjectMolecular Biology
dc.subjectCell Biology
dc.titleThe architecture of the 10-23 DNAzyme and its implications for DNA-mediated catalysisen
dc.typejournal article
degois.publication.titleFEBS Journal
dspace.entity.typePublication
oaire.awardNumber660258
oaire.awardTitleEpidermal growth factor receptor (EGFR) activation by cytohesins - Structural Insights
oaire.awardURIinfo:eu-repo/grantAgreement/EC/H2020/660258/EU
oaire.fundingStreamH2020
project.funder.identifierhttp://doi.org/10.13039/501100008530
project.funder.nameEuropean Commission
rcaap.rightsopenAccess
relation.isProjectOfPublication6ed028d7-412f-4b2f-80b5-e6557b19e0b0
relation.isProjectOfPublication.latestForDiscovery6ed028d7-412f-4b2f-80b5-e6557b19e0b0

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