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Skeletal muscle metabolomics and blood biochemistry analysis reveal metabolic changes associated with dietary amino acid supplementation in dairy calves

2018-12-01Artigo científico Acesso aberto
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dc.contributor.authorYu, Kuai
dc.contributor.authorMatzapetakis, Manolis
dc.contributor.authorValent, Daniel
dc.contributor.authorSaco, Yolanda
dc.contributor.authorDe Almeida, André M.
dc.contributor.authorTerré, Marta
dc.contributor.authorBassols, Anna
dc.contributor.institutionMolecular, Structural and Cellular Microbiology (MOSTMICRO)
dc.contributor.institutionInstituto de Tecnologia Química e Biológica António Xavier (ITQB)
dc.contributor.pblNature Publishing Group
dc.date.accessioned2019-05-06T22:15:33Z
dc.date.available2019-05-06T22:15:33Z
dc.date.issued2018-12-01
dc.description.abstractThe effects of different amino acid (AA) supplementations of milk protein-based milk replacers in pre-ruminant calves from 3 days to 7 weeks of age were studied. Animals were divided into 4 groups: Ctrl) Control group fed with milk protein-based milk replacer without supplementation; GP) supplementation with 0.1% glycine and 0.3% proline; FY) supplementation with 0.2% phenylalanine and 0.2% tyrosine; MKT) supplementation with 0.62% lysine, 0.22% methionine and 0.61% threonine. For statistical analysis, t-test was used to compare AA-supplemented animals to the Ctrl group. At week 7, body weight and average daily gain (ADG) were measured and blood samples and skeletal muscle biopsies were taken. Blood biochemistry analytes related to energy metabolism were determined and it was shown that MKT group had higher serum creatinine and higher plasma concentration of three supplemented AAs as well as arginine compared with the Ctrl group. GP group had similar glycine/proline plasma concentration compared with the other groups while in FY group only plasma phenylalanine concentration was higher compared with Control. Although the AA supplementations in the GP and FY groups did not affect average daily gain and metabolic health profile from serum, the metabolome analysis from skeletal muscle biopsy revealed several differences between the GP-FY groups and the Ctrl-MKT groups, suggesting a metabolic adaptation especially in GP and FY groups.en
dc.description.versionpublishersversion
dc.description.versionpublished
dc.format.extent1460599
dc.identifier.doi10.1038/s41598-018-32241-4
dc.identifier.issn2045-2322
dc.identifier.otherPURE: 12560244
dc.identifier.otherPURE UUID: 7fc6441f-efd9-4fb2-964c-0e0aaed62ade
dc.identifier.otherScopus: 85053294138
dc.identifier.urihttp://www.scopus.com/inward/record.url?scp=85053294138&partnerID=8YFLogxK
dc.identifier.urlhttps://www.scopus.com/pages/publications/85053294138
dc.language.isoeng
dc.peerreviewedyes
dc.subjectGeneral
dc.titleSkeletal muscle metabolomics and blood biochemistry analysis reveal metabolic changes associated with dietary amino acid supplementation in dairy calvesen
dc.typejournal article
degois.publication.issue1
degois.publication.titleScientific Reports
degois.publication.volume8
dspace.entity.typePublication
rcaap.rightsopenAccess

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