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B Cells and Double-Negative B Cells (CD27−IgD−) Are Related to Acute Pancreatitis Severity

2024-01Artigo científico Acesso aberto
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dc.contributor.authorMalheiro, Filipa
dc.contributor.authorÂngelo-Dias, Miguel
dc.contributor.authorLopes, Teresa
dc.contributor.authorAzeredo-Lopes, Sofia
dc.contributor.authorMartins, Catarina
dc.contributor.authorBorrego, Luis Miguel
dc.contributor.authorBORREGO, LUIS MIGUEL
dc.contributor.institutionNOVA Medical School|Faculdade de Ciências Médicas (NMS|FCM)
dc.contributor.institutionComprehensive Health Research Centre (CHRC) - pólo NMS
dc.contributor.pblMDPI - Multidisciplinary Digital Publishing Institute
dc.date.accessioned2024-02-19T23:52:06Z
dc.date.available2024-02-19T23:52:06Z
dc.date.issued2024-01
dc.descriptionFunding Information: This research was funded by the Learning Health Hospital da Luz. LH.INV.F2019002. Publisher Copyright: © 2024 by the authors.
dc.description.abstractAcute pancreatitis (AP) is an increasingly frequent disease in which inflammation plays a crucial role. Fifty patients hospitalized with AP were included and peripheral blood samples were analyzed for B and T cell subpopulations at the time of hospitalization and 48 h after diagnosis. The Bedside Index of Severity in Acute Pancreatitis (BISAP) and length of hospital stay were also recorded. A healthy control (HC) group of 15 outpatients was included. AP patients showed higher neutrophil/lymphocyte (N/L) ratios and higher percentages of B cells than the HC group. The total B cell percentages were higher in patients with moderate/severe AP than in patients with mild AP. The percentages of B cells as well as the percentages of the CD27−IgD− B cell subset decreased from admission to 48 h after admission. The patients with higher BISAP scores showed lower percentages of peripheral lymphocytes but higher percentages of CD27−IgD− B cells. Higher BISAP scores, N/L ratios, and peripheral blood B cell levels emerged as predictors of hospital stay length in AP patients. Our findings underscore the importance of early markers for disease severity. Additionally, the N/L ratio along with the BISAP score and circulating B cell levels form a robust predictive model for hospital stay duration of AP patients.en
dc.description.versionpublishersversion
dc.description.versionpublished
dc.format.extent4341832
dc.identifier.doi10.3390/diseases12010018
dc.identifier.issn2079-9721
dc.identifier.otherPURE: 83168409
dc.identifier.otherPURE UUID: 3bebf654-0788-4950-a93f-c650bba7adbe
dc.identifier.otherScopus: 85183422865
dc.identifier.otherPubMed: 38248369
dc.identifier.otherPubMedCentral: PMC10814478
dc.identifier.otherORCID: /0000-0003-4708-438X/work/153567110
dc.identifier.otherORCID: /0000-0003-0353-0421/work/153567205
dc.identifier.otherORCID: /0000-0001-9933-4075/work/206216928
dc.identifier.urihttp://hdl.handle.net/10362/163806
dc.identifier.urlhttps://www.scopus.com/pages/publications/85183422865
dc.language.isoeng
dc.peerreviewedyes
dc.subjectacute pancreatitis
dc.subjectB cell
dc.subjectbiomarker
dc.subjectlymphocyte
dc.subjectprognosis
dc.subjectseverity
dc.subjectT cell
dc.subjectGeneral Medicine
dc.titleB Cells and Double-Negative B Cells (CD27−IgD−) Are Related to Acute Pancreatitis Severityen
dc.typejournal article
degois.publication.issue1
degois.publication.titleDiseases
degois.publication.volume12
dspace.entity.typePublication
person.familyNameBORREGO
person.givenNameLUIS MIGUEL
person.identifier.ciencia-id4119-915F-EF0F
person.identifier.orcid0000-0003-4708-438X
person.identifier.scopus-author-id8346933500
rcaap.rightsopenAccess
relation.isAuthorOfPublication027a8b74-0ce7-4daa-9ef4-917b9ec6f95a
relation.isAuthorOfPublication.latestForDiscovery027a8b74-0ce7-4daa-9ef4-917b9ec6f95a

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