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HPV distribution in cervical cancer in Portugal. A retrospective study from 1928 to 2005

2016-12Artigo científico Acesso aberto
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dc.contributor.authorFélix, A.
dc.contributor.authorAlemany, L.
dc.contributor.authorTous, S.
dc.contributor.authorde Sanjosé, S.
dc.contributor.authorBosch, F.X.
dc.contributor.institutionCentro de Estudos de Doenças Crónicas (CEDOC)
dc.contributor.institutionNOVA Medical School|Faculdade de Ciências Médicas (NMS|FCM)
dc.contributor.pblElsevier BV
dc.date.accessioned2018-06-30T00:17:38Z
dc.date.available2018-06-30T00:17:38Z
dc.date.issued2016-12
dc.description.abstractObjectives To determine human papillomavirus (HPV) types in invasive cervical cancer in Portugal. Methods Cases diagnosed at the Instituto Português de Oncologia de Lisboa de Francisco Gentil from the year 1928 to 2005 were selected for HPV DNA detection and genotyping using SPF10/DEIA/LiPA25 system. Results Of the 1214 samples that were considered appropriate for HPV detection, 714 (58.8%; 95% CI: 56.0–61.6%) were positive for HPV DNA. This detection rate varied being lower in the first 3 decades (31.3%; 50.1%; 46.5%) and higher in the last decades (77.4–95.1%). This difference was due probably to the fixative used in the first three decades. The five most common types identified among HPV positive cases were HPV16 (58.2%), HPV18 (9.2%), HPV33 (6.2%), HPV45 (4.7%) and HPV31 (4.4%). Multiple infections were detected in 2.8% of the cases. HPV16 and 18 accounted for 67.4% of infections. There were no statistically significant changes of these types over the studied period. An increase at patient׳s age at diagnosis was observed in the last decades (pen
dc.description.versionpublishersversion
dc.description.versionpublished
dc.format.extent5
dc.format.extent276961
dc.identifier.doi10.1016/j.pvr.2016.02.003
dc.identifier.issn2405-8521
dc.identifier.otherPURE: 3163913
dc.identifier.otherPURE UUID: d452cb09-5910-4c4e-9788-5435f615cec5
dc.identifier.otherRIS: urn:443D473C6C948071EE5AA8D27D06AEB3
dc.identifier.otherScopus: 85000402144
dc.identifier.otherWOS: 000399038100008
dc.identifier.otherPubMed: 29074184
dc.identifier.otherORCID: /0000-0002-2653-2262/work/60893826
dc.identifier.urihttps://www.scopus.com/inward/record.uri?eid=2-s2.0-85000402144&doi=10.1016%2fj.pvr.2016.02.003&partnerID=40&md5=884a603a7c0d59095119f29f1857cb6d
dc.identifier.urlhttps://www.scopus.com/inward/record.uri?eid=2-s2.0-85000402144&doi=10.1016%2fj.pvr.2016.02.003&partnerID=40&md5=884a603a7c0d59095119f29f1857cb6d
dc.language.isoeng
dc.peerreviewedyes
dc.subjectHPV
dc.subjectInvasive cervical carcinoma
dc.subjectPortugal
dc.subjectRetrospective study
dc.subjectadult
dc.subjectaged
dc.subjectArticle
dc.subjectcohort analysis
dc.subjectcontrolled study
dc.subjectfemale
dc.subjectgenotype
dc.subjecthuman
dc.subjectHuman papillomavirus type 11
dc.subjectHuman papillomavirus type 16
dc.subjectHuman papillomavirus type 18
dc.subjectHuman papillomavirus type 30
dc.subjectHuman papillomavirus type 31
dc.subjectHuman papillomavirus type 33
dc.subjectHuman papillomavirus type 35
dc.subjectHuman papillomavirus type 39
dc.subjectHuman papillomavirus type 42
dc.subjectHuman papillomavirus type 45
dc.subjectHuman papillomavirus type 51
dc.subjectHuman papillomavirus type 52
dc.subjectHuman papillomavirus type 53
dc.subjectHuman papillomavirus type 56
dc.subjectHuman papillomavirus type 58
dc.subjectHuman papillomavirus type 59
dc.subjectHuman papillomavirus type 66
dc.subjectHuman papillomavirus type 67
dc.subjectHuman papillomavirus type 68
dc.subjectHuman papillomavirus type 69
dc.subjectHuman papillomavirus type 70
dc.subjectHuman papillomavirus type 73
dc.subjectHuman papillomavirus type 91
dc.subjectmajor clinical study
dc.subjectnonhuman
dc.subjectpriority journal
dc.subjectretrospective study
dc.subjectuterine cervix cancer
dc.subjectvirus detection
dc.subjectWart virus
dc.subjectSDG 3 - Good Health and Well-being
dc.titleHPV distribution in cervical cancer in Portugal. A retrospective study from 1928 to 2005en
dc.typejournal article
degois.publication.firstPage41
degois.publication.lastPage45
degois.publication.titlePapillomavirus Research
degois.publication.volume2
dspace.entity.typePublication
rcaap.rightsopenAccess

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