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Identification and Antibiotic-Susceptibility Profiling of Infectious Bacterial Agents: A Review of Current and Future Trends

2019-01-01Artigo científico Acesso aberto
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dc.contributor.authorMaugeri, Gaetano
dc.contributor.authorLychko, Iana
dc.contributor.authorSobral, Rita
dc.contributor.authorRoque, Ana C. A.
dc.contributor.institutionUCIBIO - Applied Molecular Biosciences Unit
dc.contributor.institutionDQ - Departamento de Química
dc.contributor.institutionDCV - Departamento de Ciências da Vida
dc.contributor.pblWiley
dc.date.accessioned2019-02-11T23:29:01Z
dc.date.available2019-02-11T23:29:01Z
dc.date.issued2019-01-01
dc.descriptionThis work was supported by the European Research Council through the grant reference SCENT-ERC-2014-STG-639123 (2015-2020), and by the Unidade de Ciencias Biomoleculares Aplicadas-UCIBIO, which is financed by national funds from FCT/MEC (UID/Multi/04378/2013) and co-financed by the ERDF under the PT2020 Partnership Agreement (POCI-01-0145-FEDER-007728).
dc.description.abstractAntimicrobial resistance is one of the most worrying threats to humankind with extremely high healthcare costs associated. The current technologies used in clinical microbiology to identify the bacterial agent and profile antimicrobial susceptibility are time-consuming and frequently expensive. As a result, physicians prescribe empirical antimicrobial therapies. This scenario is often the cause of therapeutic failures, causing higher mortality rates and healthcare costs, as well as the emergence and spread of antibiotic resistant bacteria. As such, new technologies for rapid identification of the pathogen and antimicrobial susceptibility testing are needed. This review summarizes the current technologies, and the promising emerging and future alternatives for the identification and profiling of antimicrobial resistance bacterial agents, which are expected to revolutionize the field of clinical diagnostics.en
dc.description.versionpublishersversion
dc.description.versionpublished
dc.format.extent1954193
dc.identifier.doi10.1002/biot.201700750
dc.identifier.issn1860-6768
dc.identifier.otherPURE: 5800850
dc.identifier.otherPURE UUID: 3fac0989-824e-4395-b7c0-dc0976b39858
dc.identifier.otherScopus: 85052470675
dc.identifier.otherWOS: 000455808800002
dc.identifier.otherPubMed: 30024110
dc.identifier.otherPubMedCentral: PMC6330097
dc.identifier.otherORCID: /0000-0003-4533-7531/work/201987284
dc.identifier.urihttp://www.scopus.com/inward/record.url?scp=85052470675&partnerID=8YFLogxK
dc.identifier.urlhttps://www.scopus.com/pages/publications/85052470675
dc.language.isoeng
dc.peerreviewedyes
dc.subjectantimicrobial resistance
dc.subjectantimicrobial susceptibility profiling
dc.subjectbacteria identification
dc.subjectclinical microbiology
dc.subjectdiagnostic methods
dc.subjectinfectious diseases
dc.subjectApplied Microbiology and Biotechnology
dc.subjectMolecular Medicine
dc.subjectSDG 3 - Good Health and Well-being
dc.titleIdentification and Antibiotic-Susceptibility Profiling of Infectious Bacterial Agents: A Review of Current and Future Trendsen
dc.typejournal article
degois.publication.issue1
degois.publication.titleBiotechnology Journal
degois.publication.volume14
dspace.entity.typePublication
rcaap.rightsopenAccess

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