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Antimicrobial Activity of Manganese(I) Tricarbonyl Complexes Bearing 1,2,3-Triazole Ligands
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Resumo(s)
Background. Antimicrobial resistance is one of the most pressing health issues of our time. The increase in the number of antibiotic-resistant bacteria allied to the lack of new antibiotics has contributed to the current crisis. It has been predicted that if this situation is not dealt with, we will be facing 10 million deaths due to multidrug resistant infections per year by 2050, surpassing cancer-related deaths. This alarming scenario has refocused attention into researching alternative drugs to treat multidrug-resistant infections. Aims. In this study, the antimicrobial activities of four manganese complexes containing 1,2,3,-triazole and clotrimazole ligands have been evaluated. It is known that azole antibiotics coordinated to manganese tricarbonyl complexes display interesting antimicrobial activities against several microbes. In this work, the effect of the introduction of 1,2,3,-triazole-derived ligands in the [Mn(CO)3(clotrimazole)] fragment has been investigated against one Gram-positive bacterium and five Gram-negative bacteria. Methods. The initial antimicrobial activity of the above-mentioned complexes was assessed by determining the minimum inhibitory and bactericidal concentrations using the broth microdilution method. Growth curves in the presence and absence of the complexes were performed to determine the effects of these complexes on the growth of the selected bacteria. A possible impact on cellular viability was determined by conducting the MTS assay on human monocytes. Results. Three of the Mn complexes investigated (4–6) had good antimicrobial activities against all the bacteria tested, with values ranging from 1.79 to 61.95 µM with minimal toxicity. Conclusions. Due to the increased problem of antibiotic resistance and a lack of new antibacterial drugs with no toxicity, these results are exciting and show that these types of complexes can be an avenue to pursue in the future.
Descrição
Funding Information: We are grateful to Fundação para a Ciência e a Tecnologia, I.P., through DOI 10.54499/PTDC/QUI-QIN/0359/2021, MOSTMICRO- ITQB R&D Unit (UIDB/04612/2020 and UIDP/04612/2020) and LS4FUTURE Associated Laboratory (LA/P/0087/2020). The NMR data were acquired at CERMAX, ITQB NOVA, Oeiras, Portugal, with equipment funded by FCT, project AAC 01/SAIC/2016. Oscar A. Lenis-Rojas acknowledge national funds through FCT, POPH-Programa Operacional Potencial Humano, and FSE (European Social Fund) for the CEEC 2017 Initiative. This work was partially funded by the Department of Microbiology, Trinity College Dublin, Ireland. C. Trigueiros’ work is funded under a Provost Ph.D. Award provided by Trinity College Dublin, Dublin, Ireland. Funding of the Martins lab is also supported by Welcome Trust. This work was supported by the Associate Laboratory for Green Chemistry- LAQV, UCIBIO, and i4HB, which are financed by national funds from FCT/MCTES (UIDB/50006/2020, UIDP/50006/2020 and LA/P/0008/2020, UIDB/04378/2020 and UIDP/04378/2020, and LA/P/0140/2020, respectively). The X-ray infrastructure was financed by FCT-MCTES through project RECI/BBB-BEP/0124/2012. Publisher Copyright: © 2023 by the authors.
Palavras-chave
antibacterial activity azoles or azole derivatives manganese tricarbonyl complexes Drug Discovery Analytical Chemistry Chemistry (miscellaneous) Molecular Medicine Physical and Theoretical Chemistry Pharmaceutical Science Organic Chemistry