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Anabolic-androgen steroids

2025-02Recensão Acesso aberto
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dc.contributor.authorde Melo Junior, Antonio Ferreira
dc.contributor.authorEscouto, Leonardo
dc.contributor.authorPimpão, António B.
dc.contributor.authorPeixoto, Pollyana
dc.contributor.authorBrasil, Girlandia
dc.contributor.authorRonchi, Silas Nascimento
dc.contributor.authorPereira, Sofia Azeredo
dc.contributor.authorSA, Pereira
dc.contributor.authorBissoli, Nazaré Souza
dc.contributor.institutionNOVA Medical School|Faculdade de Ciências Médicas (NMS|FCM)
dc.contributor.institutioniNOVA4Health - pólo NMS
dc.contributor.pblElsevier
dc.date.accessioned2025-01-31T21:15:18Z
dc.date.available2025-01-31T21:15:18Z
dc.date.issued2025-02
dc.description.abstractMillions of individuals make illicit use of anabolic-androgenic steroids (AAS), remaining a public health issue. It often leads to detrimental effects, including cardiovascular and renal diseases, besides hormonal and metabolic imbalances. The objective of this review is to emphasize the contribution of oxidative stress and inflammation to these effects and connect the findings of experimental animal studies with the alterations found in clinical contexts, in AAS users. The study's results showed that AAS promotes a redox disruption and a pro-inflammatory state on organs that are involved in important physiologic processes. These drugs increase inflammatory high-sensitivity C-reactive protein (hs-CRP) and cytokines that contribute to the progression of atherosclerosis, cardiovascular disease risk or endpoints, including stroke, myocardial infarction and death. In the kidney, the AAS increase proteinuria and structural damage. Studies have linked AAS abuse with high BP, low HDL-C levels, high triglyceride levels and impaired fasting blood glucose that characterize Metabolic syndrome. Overall, the studies indicate that oxidative stress, apoptosis, and AAS-mediated inflammation play a significant role in tissue damage, regardless of the dose and duration of exposure, and we point it as a putative independent risk factor to Cardiovascular, Kidney and Metabolic syndrome.en
dc.description.versionpublishersversion
dc.description.versionpublished
dc.format.extent2304230
dc.identifier.doi10.1016/j.taap.2025.117238
dc.identifier.issn0041-008X
dc.identifier.otherPURE: 107961005
dc.identifier.otherPURE UUID: 159a691f-1f34-4f9f-819c-85d1a12e148e
dc.identifier.otherScopus: 85215617949
dc.identifier.urihttp://hdl.handle.net/10362/178235
dc.identifier.urlhttps://www.scopus.com/pages/publications/85215617949
dc.language.isoeng
dc.peerreviewedyes
dc.subjectAnabolic-androgen steroids
dc.subjectCardiovascular
dc.subjectInflammation
dc.subjectKidney and metabolic syndrome
dc.subjectOxidative stress
dc.subjectRenin angiotensin system
dc.subjectToxicology
dc.subjectPharmacology
dc.subjectSDG 3 - Good Health and Well-being
dc.titleAnabolic-androgen steroidsen
dc.title.subtitleA possible independent risk factor to Cardiovascular, Kidney and Metabolic Syndromeen
dc.typereview
degois.publication.titleToxicology and Applied Pharmacology
degois.publication.volume495
dspace.entity.typePublication
person.familyNamede Azeredo Pereira
person.givenNameSofia
person.identifier562223
person.identifier.ciencia-id6B13-7601-73A2
person.identifier.orcid0000-0002-8456-9995
person.identifier.ridM-2976-2019
person.identifier.scopus-author-id35190948700
rcaap.rightsopenAccess
relation.isAuthorOfPublicationf4809377-832b-40b5-92ca-0bb1c6fe14f3
relation.isAuthorOfPublication.latestForDiscoveryf4809377-832b-40b5-92ca-0bb1c6fe14f3

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