Logo do repositório
 
Publicação

Determinants of HIV late presentation among men who have sex with men in Portugal (2014–2019)

2024Artigo científico Acesso aberto
Ver registo simples
dc.contributor.authorAbrantes, Ricardo
dc.contributor.authorPimentel, Victor
dc.contributor.authorMiranda, Mafalda N. S.
dc.contributor.authorSilva, Ana Rita
dc.contributor.authorDiniz, António
dc.contributor.authorAscenção, Bianca
dc.contributor.authorPiñeiro, Carmela
dc.contributor.authorKoch, Carmo
dc.contributor.authorRodrigues, Catarina
dc.contributor.authorCaldas, Cátia
dc.contributor.authorMorais, Célia
dc.contributor.authorFaria, Domitília
dc.contributor.authorGomes da Silva, Elisabete
dc.contributor.authorTeófilo, Eugénio
dc.contributor.authorMonteiro, Fátima
dc.contributor.authorRoxo, Fausto
dc.contributor.authorMaltez, Fernando
dc.contributor.authorRodrigues, Fernando
dc.contributor.authorGaião, Guilhermina
dc.contributor.authorRamos, Helena
dc.contributor.authorCosta, Inês
dc.contributor.authorGermano, Isabel
dc.contributor.authorSimões, Joana
dc.contributor.authorOliveira, Joaquim
dc.contributor.authorFerreira, José
dc.contributor.authorPoças, José
dc.contributor.authorSoares, Jorge
dc.contributor.authorSaraiva da Cunha, José
dc.contributor.authorFernandes, Sandra
dc.contributor.authorMansinho, Kamal
dc.contributor.authorPedro, Liliana
dc.contributor.authorAleixo, Maria João
dc.contributor.authorGonçalves, Maria João
dc.contributor.authorManata, Maria José
dc.contributor.authorMouro, Margarida
dc.contributor.authorSerrado, Margarida
dc.contributor.authorCaixeiro, Micaela
dc.contributor.authorMarques, Nuno Miguel
dc.contributor.authorCosta, Olga
dc.contributor.authorPacheco, Patrícia
dc.contributor.authorProença, Paula
dc.contributor.authorRodrigues, Paulo
dc.contributor.authorPinho, Raquel
dc.contributor.authorTavares, Raquel
dc.contributor.authorCorreia de Abreu, Ricardo
dc.contributor.authorCôrte-Real, Rita
dc.contributor.authorSerrão, Rosário
dc.contributor.authorSarmento e Castro, Rui
dc.contributor.authorNunes, Sofia
dc.contributor.authorFaria, Telo
dc.contributor.authorBaptista, Teresa
dc.contributor.authorSimões, Daniel
dc.contributor.authorMendão, Luis
dc.contributor.authorMartins, M. Rosário O.
dc.contributor.authorGomes, Perpétua
dc.contributor.authorPingarilho, Marta
dc.contributor.authorAbecasis, Ana B.
dc.contributor.institutionTB, HIV and opportunistic diseases and pathogens (THOP)
dc.contributor.institutionGlobal Health and Tropical Medicine (GHTM)
dc.contributor.institutionInstituto de Higiene e Medicina Tropical (IHMT)
dc.contributor.institutionLaboratório Associado de Translacção e Inovação para a Saúde Global - LA Real (Pólo IHMT)
dc.contributor.institutionPopulation health, policies and services (PPS)
dc.contributor.pblFrontiers Media
dc.date.accessioned2024-09-30T22:30:26Z
dc.date.available2024-09-30T22:30:26Z
dc.date.issued2024
dc.descriptionFunding Information: The author(s) declare financial support was received for the research, authorship, and/or publication of this article. This study was supported by the European funds through grant Bio-Molecular and Epidemiological Surveillance of HIV Transmitted Drug Resistance, Hepatitis Co-Infections and Ongoing Transmission Patterns in Europe (BEST HOPE) (project funded through HIVERA: Harmonizing Integrating Vitalizing European Research on HIV/AIDS, grant no: 249697); by FCT for funds to GHTM-UID/Multi/04413/2013, GHTM-UID/04413/2020 and LA-REAL - LA/P/0117/2020; by the MigrantHIV project (financed by FCT: PTDC/DTP-EPI/7066/2014); by Characterization of drug-resistance TB and HIV, and associated sociobehavioral factors among migrants in Lisbon, Portugal project financed by GHTM-UID/Multi/04413/2013; by Integriv project (financed by FCT: PTDC/SAUINF/31990/2017) and the MARVEL project (financed by FCT: PTDC/SAU-PUB/4018/2021). This study was financed by the Gilead Génese programme through funding to project HIVLatePresenters. Publisher Copyright: Copyright © 2024 Abrantes, Pimentel, Miranda, Silva, Diniz, Ascenção, Piñeiro, Koch, Rodrigues, Caldas, Morais, Faria, Gomes da Silva, Teófilo, Monteiro, Roxo, Maltez, Rodrigues, Gaião, Ramos, Costa, Germano, Simões, Oliveira, Ferreira, Poças, Saraiva da Cunha, Soares, Fernandes, Mansinho, Pedro, Aleixo, Gonçalves, Manata, Mouro, Serrado, Caixeiro, Marques, Costa, Pacheco, Proença, Rodrigues, Pinho, Tavares, Correia de Abreu, Côrte-Real, Serrão, Sarmento e Castro, Nunes, Faria, Baptista, Simões, Mendão, Martins, Gomes, Pingarilho, Abecasis and the BESTHOPE Study Group.
dc.description.abstractIntroduction: HIV late presentation (LP) remains excessive in Europe. We aimed to analyze the factors associated with late presentation in the MSM population newly diagnosed with HIV in Portugal between 2014 and 2019. Methods: We included 391 newly HIV-1 diagnosed Men who have Sex with Men (MSM), from the BESTHOPE project, in 17 countrywide Portuguese hospitals. The data included clinical and socio-behavioral questionnaires and the viral genomic sequence obtained in the drug resistance test before starting antiretrovirals (ARVs). HIV-1 subtypes and epidemiological surveillance mutations were determined using different bioinformatics tools. Logistic regression was used to estimate the association between predictor variables and late presentation (LP). Results: The median age was 31 years, 51% had a current income between 501–1,000 euros, 28% were migrants. 21% had never been tested for HIV before diagnosis, with 42.3% of MSM presenting LP. 60% were infected with subtype B strains. In the multivariate regression, increased age at diagnosis, higher income, lower frequency of screening, STI ever diagnosed and higher viral load were associated with LP. Conclusion: Our study suggests that specific subgroups of the MSM population, such older MSM, with higher income and lower HIV testing frequency, are not being targeted by community and clinical screening services. Overall, targeted public health measures should be strengthened toward these subgroups, through strengthened primary care testing, expanded access to PrEP, information and promotion of HIV self-testing and more inclusive and accessible health services.en
dc.description.versionpublishersversion
dc.description.versionpublished
dc.format.extent884631
dc.identifier.doi10.3389/fpubh.2024.1336845
dc.identifier.issn2296-2565
dc.identifier.otherPURE: 99692355
dc.identifier.otherPURE UUID: 25ecaf7f-f003-4d94-a856-e17710682eab
dc.identifier.otherScopus: 85188141383
dc.identifier.otherWOS: 001190522700001
dc.identifier.otherPubMed: 38500732
dc.identifier.otherPubMedCentral: PMC10947991
dc.identifier.otherORCID: /0000-0002-7941-0285/work/168642455
dc.identifier.urihttp://hdl.handle.net/10362/172719
dc.identifier.urlhttps://www.scopus.com/pages/publications/85188141383
dc.language.isoeng
dc.peerreviewedyes
dc.subjectdrug resistance
dc.subjectHIV-1
dc.subjectlate presentation
dc.subjectmen who have sex with men
dc.subjectPortugal
dc.subjectvulnerable populations
dc.subjectPublic Health, Environmental and Occupational Health
dc.subjectSDG 3 - Good Health and Well-being
dc.titleDeterminants of HIV late presentation among men who have sex with men in Portugal (2014–2019)en
dc.title.subtitlewho’s being left behind?en
dc.typejournal article
degois.publication.titleFrontiers in public health
degois.publication.volume12
dspace.entity.typePublication
rcaap.rightsopenAccess

Ficheiros

Principais
A mostrar 1 - 1 de 1
Miniatura
Nome:
Determinants_of_HIV_late_presentation_among_men_who_have_sex_with_men_in_Portugal_2014_2019_.pdf
Tamanho:
863.9 KB
Formato:
Adobe Portable Document Format
Ver/Abrir

Coleções

Home collection (IHMT)