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HBM4EU Diisocyanates Study-Research Protocol for a Collaborative European Human Biological Monitoring Study on Occupational Exposure

2022-07-20Artigo científico Acesso aberto
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dc.contributor.authorJones, Kate
dc.contributor.authorGalea, Karen S
dc.contributor.authorScholten, Bernice
dc.contributor.authorLoikala, Marika
dc.contributor.authorPorras, Simo P
dc.contributor.authorBousoumah, Radia
dc.contributor.authorNdaw, Sophie
dc.contributor.authorLeese, Elizabeth
dc.contributor.authorLouro, Henriqueta
dc.contributor.authorSilva, Maria João
dc.contributor.authorViegas, Susana
dc.contributor.authorGodderis, Lode
dc.contributor.authorVerdonck, Jelle
dc.contributor.authorPoels, Katrien
dc.contributor.authorGӧen, Thomas
dc.contributor.authorDuca, Radu-Corneliu
dc.contributor.authorSantonen, Tiina
dc.contributor.authorHbm Eu Diisocyanates Study Team
dc.contributor.institutionCentre for Toxicogenomics and Human Health (ToxOmics)
dc.contributor.institutionNOVA Medical School|Faculdade de Ciências Médicas (NMS|FCM)
dc.contributor.institutionEscola Nacional de Saúde Pública (ENSP)
dc.contributor.institutionCentro de Investigação em Saúde Pública (CISP/PHRC)
dc.contributor.institutionComprehensive Health Research Centre (CHRC) - Pólo ENSP
dc.contributor.pblMolecular Diversity Preservation International (MDPI)
dc.date.accessioned2022-07-29T22:25:13Z
dc.date.available2022-07-29T22:25:13Z
dc.date.issued2022-07-20
dc.descriptionFunding: This work has received external funding from the European Union’s Horizon 2020 research and innovation program under grant agreement No. 733032 and received co-funding from the author’s organizations and/or Ministries.
dc.description.abstractDiisocyanates have long been a leading cause of occupational asthma in Europe, and recently, they have been subjected to a restriction under the REACH regulations. As part of the European Human Biomonitoring project (HBM4EU), we present a study protocol designed to assess occupational exposure to diisocyanates in five European countries. The objectives of the study are to assess exposure in a number of sectors that have not been widely reported on in the past (for example, the manufacturing of large vehicles, such as in aerospace; the construction sector, where there are potentially several sources of exposure (e.g., sprayed insulation, floor screeds); the use of MDI-based glues, and the manufacture of spray adhesives or coatings) to test the usability of different biomarkers in the assessment of exposure to diisocyanates and to provide background data for regulatory purposes. The study will collect urine samples (analysed for diisocyanate-derived diamines and acetyl-MDI-lysine), blood samples (analysed for diisocyanate-specific IgE and IgG antibodies, inflammatory markers, and diisocyanate-specific Hb adducts for MDI), and buccal cells (micronucleus analysis) and measure fractional exhaled nitric oxide. In addition, occupational hygiene measurements (air monitoring and skin wipe samples) and questionnaire data will be collected. The protocol is harmonised across the participating countries to enable pooling of data, leading to better and more robust insights and recommendations.en
dc.description.versionpublishersversion
dc.description.versionpublished
dc.format.extent362088
dc.identifier.doi10.3390/ijerph19148811
dc.identifier.issn1660-4601
dc.identifier.otherPURE: 45692721
dc.identifier.otherPURE UUID: 63ab9c3d-cc4b-49ce-aec1-535909019e82
dc.identifier.otherPubMed: 35886663
dc.identifier.otherScopus: 85135127604
dc.identifier.otherWOS: 000833349400001
dc.identifier.urihttp://hdl.handle.net/10362/142696
dc.language.isoeng
dc.peerreviewedyes
dc.subjectBiological Monitoring
dc.subjectBiomarkers
dc.subjectEnvironmental Monitoring/methods
dc.subjectHumans
dc.subjectIsocyanates/analysis
dc.subjectMouth Mucosa
dc.subjectOccupational Exposure/analysis
dc.titleHBM4EU Diisocyanates Study-Research Protocol for a Collaborative European Human Biological Monitoring Study on Occupational Exposureen
dc.typejournal article
degois.publication.issue14
degois.publication.titleInternational Journal of Environmental Research and Public Health
degois.publication.volume19
dspace.entity.typePublication
rcaap.rightsopenAccess

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