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Targeting Lysosomal Dysfunction and Oxidative Stress in Age-Related Macular Degeneration

2025-05Recensão Acesso aberto
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dc.contributor.authorFalcão, Ana S.
dc.contributor.authorAS, Falcão
dc.contributor.authorPedro, Margarida L.
dc.contributor.authorTenreiro, Sandra
dc.contributor.authorTenreiro, Sandra
dc.contributor.authorSeabra, Miguel C.
dc.contributor.authorC Seabra, Miguel
dc.contributor.institutioniNOVA4Health - pólo NMS
dc.contributor.institutionNOVA Medical School|Faculdade de Ciências Médicas (NMS|FCM)
dc.contributor.pblMDPI - Multidisciplinary Digital Publishing Institute
dc.date.accessioned2025-07-01T21:17:46Z
dc.date.available2025-07-01T21:17:46Z
dc.date.issued2025-05
dc.descriptionFunding Information: The authors acknowledge the support by the European COST Action CA20121: Bench to bedside transition for pharmacological regulation of NRF2 in noncommunicable diseases (BenBedPhar). Webpage: https://benbedphar.org/about-benbedphar/ , accessed on 1 May 2025. Funding Information: Funded by \u201CLa Caixa\u2019 Foundation\u201D under the agreement HR22-00569 NASCENT and by the Research Unit UID/04462: iNOVA4Health\u2014Programa de Medicina Translacional and the Associated Laboratory LS4FUTURE (LA/P/0087/2020), both financially supported by Funda\u00E7\u00E3o para a Ci\u00EAncia e Tecnologia / Minist\u00E9rio da Educa\u00E7\u00E3o, Ci\u00EAncia e Inova\u00E7\u00E3o. Publisher Copyright: © 2025 by the authors.
dc.description.abstractAge-related macular degeneration (AMD) is the leading cause of vision loss in the Western world, and it currently lacks effective therapy. It is believed that AMD initiates in the aged retinal pigment epithelium (RPE), which presents lysosomal dysfunction and oxidative stress (OxS) that ultimately leads to RPE damage and AMD progression. AMD is a complex pathology, so multitarget treatments are required to act on different pathways, presenting several challenges. In this review, we discuss the current knowledge on the pathogenesis of this disease, focusing mainly on lysosomal dysfunction and OxS. Because transcription factors regulate homeostasis, the transcription factor EB (TFEB), which controls lysosomal function and biogenesis, and the nuclear factor erythroid 2-related factor 2 (NRF2), which manages OxS, have been proposed as promising targets for disease intervention. Finally, we discuss the interplay of these pathways for a potential synergistic effect on AMD-targeted therapies, as they could change the course of today’s available treatments for AMD.en
dc.description.versionpublishersversion
dc.description.versionpublished
dc.format.extent2078779
dc.identifier.doi10.3390/antiox14050596
dc.identifier.issn2076-3921
dc.identifier.otherPURE: 118628312
dc.identifier.otherPURE UUID: cb901666-2d72-4d18-a843-7f2cf711616b
dc.identifier.otherScopus: 105007651012
dc.identifier.urihttp://hdl.handle.net/10362/184706
dc.identifier.urlhttps://www.scopus.com/pages/publications/105007651012
dc.language.isoeng
dc.peerreviewedyes
dc.subjectage-related macular degeneration
dc.subjectlysosomal dysfunction
dc.subjectNRF2
dc.subjectoxidative stress
dc.subjectretinal pigment epithelium
dc.subjectTFEB/mTORC1 axis
dc.subjectFood Science
dc.subjectPhysiology
dc.subjectBiochemistry
dc.subjectMolecular Biology
dc.subjectClinical Biochemistry
dc.subjectCell Biology
dc.titleTargeting Lysosomal Dysfunction and Oxidative Stress in Age-Related Macular Degenerationen
dc.typereview
degois.publication.issue5
degois.publication.titleAntioxidants
degois.publication.volume14
dspace.entity.typePublication
person.familyNameFalcão
person.familyNameTenreiro
person.familyNameSeabra
person.givenNameAna
person.givenNameSandra
person.givenNameMiguel
person.identifier1983613
person.identifier.ciencia-idEC17-1F25-9969
person.identifier.ciencia-id2214-5455-2764
person.identifier.ciencia-id2512-FAEF-E26F
person.identifier.orcid0000-0002-4491-7457
person.identifier.orcid0000-0001-7272-5842
person.identifier.orcid0000-0002-6404-4892
person.identifier.ridM-5600-2013
person.identifier.ridA-9289-2013
person.identifier.ridM-3280-2013
person.identifier.scopus-author-id8896201400
person.identifier.scopus-author-id6602925840
person.identifier.scopus-author-id7004369652
rcaap.rightsopenAccess
relation.isAuthorOfPublication7baf07a3-9ea7-4765-bf51-88caf9163a5c
relation.isAuthorOfPublication69a3db58-3303-47a3-a7bb-b19d9ba8c36a
relation.isAuthorOfPublicationd6eeb095-df2d-4fd0-8241-ab826e5ecb1d
relation.isAuthorOfPublication.latestForDiscoveryd6eeb095-df2d-4fd0-8241-ab826e5ecb1d

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