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Gamma Irradiation Processing on 3D PCL Devices—A Preliminary Biocompatibility Assessment

2022-12Artigo científico Acesso aberto
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dc.contributor.authorGuedes, Fernando
dc.contributor.authorBranquinho, Mariana V.
dc.contributor.authorBiscaia, Sara
dc.contributor.authorAlvites, Rui D.
dc.contributor.authorSousa, Ana C.
dc.contributor.authorLopes, Bruna
dc.contributor.authorSousa, Patrícia
dc.contributor.authorRêma, Alexandra
dc.contributor.authorAmorim, Irina
dc.contributor.authorFaria, Fátima
dc.contributor.authorPatrício, Tatiana M.
dc.contributor.authorAlves, Nuno
dc.contributor.authorBugalho, António
dc.contributor.authorMaurício, Ana C.
dc.contributor.institutionNOVA Medical School|Faculdade de Ciências Médicas (NMS|FCM)
dc.contributor.institutionCentro de Estudos de Doenças Crónicas (CEDOC)
dc.contributor.pblMDPI - Multidisciplinary Digital Publishing Institute
dc.date.accessioned2023-01-09T22:16:27Z
dc.date.available2023-01-09T22:16:27Z
dc.date.issued2022-12
dc.descriptionFunding Information: Mariana Vieira Branquinho (SFRH/BD/146172/2019), Ana Catarina Sousa (SFRH/BD/146689/2019), and Bruna Lopes (2021.05265.BD) acknowledge the Fundação para a Ciência e Tecnologia (FCT)’s financial support. Rui Damásio Alvites acknowledges the Animal Science Studies Centre (CECA), Agroenvironment, Technologies and Sciences Institute (ICETA), Porto University (UP), and FCT for the funding and availability of all technical, structural, and human resources necessary for the development of this work. The work was supported through the project UIDB/00211/2020 funded by FCT/MCTES, national funds. This research was funded by Projects PEst-OE/AGR/UI0211/2011 from FCT, and COMPETE 2020, from ANI–Projetos ID&T Empresas em Copromoção, by the project “Print-on-Organs–Engineering bioinks and processes for direct printing on organs” with the reference POCI-01-0247-FEDER-033877, by the project “Bone2Move-Development of “in vivo” experimental tech-niquesand modelling methodologies for the evaluation of 4D scaffolds for bone defect in sheepmodel: an integrative research approach” with the reference POCI-01-0145-FEDER-031146. Publisher Copyright: © 2022 by the authors.
dc.description.abstractAdditive manufacturing or 3D printing applying polycaprolactone (PCL)-based medical devices represents an important branch of tissue engineering, where the sterilization method is a key process for further safe application in vitro and in vivo. In this study, the authors intend to access the most suitable gamma radiation conditions to sterilize PCL-based scaffolds in a preliminary biocompatibility assessment, envisioning future studies for airway obstruction conditions. Three radiation levels were considered, 25 kGy, 35 kGy and 45 kGy, and evaluated as regards their cyto- and biocompatibility. All three groups presented biocompatible properties, indicating an adequate sterility condition. As for the cytocompatibility analysis, devices sterilized with 35 kGy and 45 kGy showed better results, with the 45 kGy showing overall improved outcomes. This study allowed the selection of the most suitable sterilization condition for PCL-based scaffolds, aiming at immediate future assays, by applying 3D-customized printing techniques to specific airway obstruction lesions of the trachea.en
dc.description.versionpublishersversion
dc.description.versionpublished
dc.format.extent4448180
dc.identifier.doi10.3390/ijms232415916
dc.identifier.issn1661-6596
dc.identifier.otherPURE: 49451319
dc.identifier.otherPURE UUID: 7669b13c-bf86-47c4-9fa3-a61091754994
dc.identifier.otherScopus: 85144558091
dc.identifier.otherPubMed: 36555555
dc.identifier.otherWOS: 000902418900001
dc.identifier.urihttp://hdl.handle.net/10362/147234
dc.identifier.urlhttps://www.scopus.com/pages/publications/85144558091
dc.language.isoeng
dc.peerreviewedyes
dc.subject3D printing
dc.subjectbiocompatibility
dc.subjectcytocompatibility
dc.subjectgamma irradiation
dc.subjectmesenchymal stem cells
dc.subjectpolycaprolactone
dc.subjectCatalysis
dc.subjectMolecular Biology
dc.subjectSpectroscopy
dc.subjectComputer Science Applications
dc.subjectPhysical and Theoretical Chemistry
dc.subjectOrganic Chemistry
dc.subjectInorganic Chemistry
dc.titleGamma Irradiation Processing on 3D PCL Devices—A Preliminary Biocompatibility Assessmenten
dc.typejournal article
degois.publication.issue24
degois.publication.titleInternational Journal of Molecular Sciences
degois.publication.volume23
dspace.entity.typePublication
rcaap.rightsopenAccess

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