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Liaisons dangereuses:

2019-09-23Artigo científico Acesso aberto
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dc.contributor.authorSalgueiro, Patrícia
dc.contributor.authorRestrepo-Zabaleta, Johana
dc.contributor.authorCosta, Monique
dc.contributor.authorGalardo, Allan Kardec Ribeiro
dc.contributor.authorGaborit, Pascal
dc.contributor.authorGuidez, Amandine
dc.contributor.authorMartins, Ademir Jesus
dc.contributor.authorDusfour, Isabelle
dc.contributor.authorPinto, J
dc.contributor.institutionInstituto de Higiene e Medicina Tropical (IHMT)
dc.contributor.institutionGlobal Health and Tropical Medicine (GHTM)
dc.contributor.institutionVector borne diseases and pathogens (VBD)
dc.contributor.pblMemorias Do Instituto Oswaldo Cruz / Instituto Oswaldo Cruz, Ministério da Saúde
dc.date.accessioned2021-05-02T22:45:09Z
dc.date.available2021-05-02T22:45:09Z
dc.date.issued2019-09-23
dc.description.abstractBACKGROUND: In recent years, South America has suffered the burden of continuous high impact outbreaks of dengue, chikungunya and Zika. Aedes aegypti is the main mosquito vector of these arboviruses and its control is the only solution to reduce transmission. OBJECTIVES: In order to improve vector control it is essential to study mosquito population genetics in order to better estimate the population structures and the geneflow among them.  METHODS: We have analysed microsatellites and knockdown resistance (kdr) mutations from a trans-border region in Amazonia between the state of Amapá (Brazil) and French Guiana (overseas territory of France), to provide further knowledge on these issues. These two countries have followed distinct vector control policies since last century. For population genetic analyses we evaluated variability in 13 well-established microsatellites loci in Ae. aegypti from French Guiana (Saint Georges and Cayenne) and Brazil (Oiapoque and Macapá). The occurrence and frequency of kdr mutations in these same populations were accessed by TaqMan genotype assays for the sites 1016 (Val/Ile) and 1534 (Phe/Cys).  FINDINGS: We have detected high levels of gene flow between the closest cross-border samples of Saint-Georges and Oiapoque. These results suggest one common origin of re-colonisation for the populations of French Guiana and Oiapoque in Brazil, and a different source for Macapá, more similar to the other northern Brazilian populations. Genotyping of the kdr mutations revealed distinct patterns for Cayenne and Macapá associated with their different insecticide use history, and an admixture zone between these two patterns in Saint Georges and Oiapoque, in accordance with population genetic results.  MAIN CONCLUSIONS: The present study highlights the need for regional-local vector surveillance and transnational collaboration between neighboring countries to assess the impact of implemented vector control strategies, promote timely actions and develop preparedness plans.en
dc.description.versionpublishersversion
dc.description.versionpublished
dc.format.extent9
dc.format.extent2425759
dc.identifier.doi10.1590/0074-02760190120
dc.identifier.issn0074-0276
dc.identifier.otherPURE: 14983137
dc.identifier.otherPURE UUID: f87125ca-19c7-479d-9c0e-ab51f0cac914
dc.identifier.otherScopus: 85072602013
dc.identifier.otherPubMed: 31553370
dc.identifier.otherPubMedCentral: PMC6759281
dc.identifier.otherORCID: /0000-0001-8572-7708/work/63725329
dc.identifier.otherORCID: /0000-0001-8628-3651/work/64040736
dc.identifier.otherWOS: 000488017600001
dc.identifier.urihttp://hdl.handle.net/10362/116723
dc.identifier.urlhttps://www.scopus.com/pages/publications/85072602013
dc.language.isoeng
dc.peerreviewedyes
dc.subjectAedes aegypti
dc.subjectInsecticide resistance
dc.subjectPopulation genetics
dc.subjectVector control
dc.subjectBrazil
dc.subjectFrench Guiana
dc.subjectGenetics
dc.subjectEcology, Evolution, Behavior and Systematics
dc.subjectInsect Science
dc.subjectInfectious Diseases
dc.subjectSDG 3 - Good Health and Well-being
dc.subjectSDG 15 - Life on Land
dc.titleLiaisons dangereuses:en
dc.title.subtitlecross-border gene flow and dispersal of insecticide resistance-associated genes in the mosquito Aedes aegypti from Brazil and French Guianaen
dc.typejournal article
degois.publication.firstPagee190120
degois.publication.issue8
degois.publication.lastPagee190129
degois.publication.titleMemórias do Instituto Oswaldo Cruz
degois.publication.volume114
dspace.entity.typePublication
rcaap.rightsopenAccess

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