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Epidemiology and clinical presentation of community-acquired Staphylococcus aureus bacteraemia in children under 5 years of age admitted to the Manhica District Hospital, Mozambique, 2001-2019

2023-03-18Artigo científico Acesso aberto
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dc.contributor.authorGarrine, M
dc.contributor.authorQuinto, L
dc.contributor.authorCosta, SS
dc.contributor.authorMessa, A
dc.contributor.authorMassinga, AJ
dc.contributor.authorVubil, D
dc.contributor.authorNhampossa, T
dc.contributor.authorMassora, S
dc.contributor.authorAcacio, S
dc.contributor.authorCossa, A
dc.contributor.authorSigauque, B
dc.contributor.authorBassat, Q
dc.contributor.authorCouto, I
dc.contributor.authorMandomando, I
dc.contributor.institutionInstituto de Higiene e Medicina Tropical (IHMT)
dc.contributor.institutionGlobal Health and Tropical Medicine (GHTM)
dc.contributor.institutionTB, HIV and opportunistic diseases and pathogens (THOP)
dc.contributor.pblSpringer
dc.date.accessioned2023-07-06T22:14:19Z
dc.date.available2023-07-06T22:14:19Z
dc.date.issued2023-03-18
dc.description.abstractStaphylococcus aureus bacteraemia (SAB) is one of the most common bloodstream infections globally. Data on the burden and epidemiology of community-acquired SAB in low-income countries are scarce but needed to defne preventive and management strategies. Blood samples were collected from children<5 years of age with fever or severe disease admitted to the Manhiça District Hospital for bacterial isolation, including S. aureus. Between 2001 and 2019, 7.6% (3,197/41,891) of children had bacteraemia, of which 12.3% corresponded to SAB. The overall incidence of SAB was 56.1 episodes/100,000 children-years at risk (CYAR), being highest among neonates (589.8 episodes/100,000 CYAR). SAB declined signifcantly between 2001 and 2019 (322.1 to 12.5 episodes/100,000 CYAR). In-hospital mortality by SAB was 9.3% (31/332), and signifcantly associated with infections by multidrugresistant (MDR) strains (14.7%, 11/75 vs. 6.9%, 14/204 among non-MDR, p=0.043) and methicillin-resistant S. aureus (33.3%, 5/15 vs. 7.6%, 20/264 among methicillin-susceptible S. aureus, p=0.006). Despite the declining rates of SAB, this disease remains an important cause of death among children admitted to MDH, possibly in relation to the resistance to the frst line of empirical treatment in use in our setting, suggesting an urgent need to review current policy recommendationsen
dc.description.versionpublishersversion
dc.description.versionpublished
dc.format.extent7
dc.format.extent1303035
dc.identifier.doi10.1007/s10096-023-04580-2
dc.identifier.issn0934-9723
dc.identifier.otherPURE: 64129017
dc.identifier.otherPURE UUID: 3bd411ef-a118-4d81-8676-da51ca542bd6
dc.identifier.otherWOS: 000949393900001
dc.identifier.otherPubMed: 36932278
dc.identifier.otherPubMedCentral: PMC10023310
dc.identifier.otherScopus: 85150057003
dc.identifier.otherORCID: /0000-0002-4096-2410/work/151391886
dc.identifier.otherORCID: /0000-0003-3536-2733/work/151411250
dc.identifier.urihttp://hdl.handle.net/10362/154918
dc.identifier.urlhttps://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=nova_api&SrcAuth=WosAPI&KeyUT=WOS:000949393900001&DestLinkType=FullRecord&DestApp=WOS
dc.language.isoeng
dc.peerreviewedyes
dc.subjectBacteraemia
dc.subjectEpidemiology
dc.subjectIncidence
dc.subjectPaediatric
dc.subjectStaphylococcus aureus
dc.subjectRJ Pediatrics
dc.subjectQR Microbiology
dc.subjectMicrobiology
dc.subjectPediatrics, Perinatology, and Child Health
dc.subjectInfectious Diseases
dc.subjectEpidemiology
dc.subjectHealth Policy
dc.subjectSDG 3 - Good Health and Well-being
dc.subjectSDG 10 - Reduced Inequalities
dc.titleEpidemiology and clinical presentation of community-acquired Staphylococcus aureus bacteraemia in children under 5 years of age admitted to the Manhica District Hospital, Mozambique, 2001-2019en
dc.typejournal article
degois.publication.firstPage653
degois.publication.issue5
degois.publication.lastPage659
degois.publication.titleEuropean Journal of Clinical Microbiology & Infectious Diseases
degois.publication.volume42
dspace.entity.typePublication
rcaap.rightsopenAccess

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