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Which imaging outcomes for axSpA are most sensitive to change?

2022-02Artigo científico Acesso aberto
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dc.contributor.authorSepriano, Alexandre
dc.contributor.authorSepriano, Alexandre
dc.contributor.authorRamiro, Sofia
dc.contributor.authorRamiro, Sofia
dc.contributor.authorvan der Heijde, Désirée
dc.contributor.authorDougados, Maxime
dc.contributor.authorClaudepierre, Pascal
dc.contributor.authorFeydy, Antoine
dc.contributor.authorReijnierse, Monique
dc.contributor.authorLoeuille, Damien
dc.contributor.authorLandewé, Robert
dc.contributor.institutionNOVA Medical School|Faculdade de Ciências Médicas (NMS|FCM)
dc.contributor.pblWiley-Blackwell
dc.date.accessioned2022-02-03T23:23:36Z
dc.date.available2022-02-03T23:23:36Z
dc.date.issued2022-02
dc.description.abstractOBJECTIVE: To compare the sensitivity to change of different imaging scoring methods in patients with early axial spondyloarthritis (axSpA). METHODS: Patients from the DESIR cohort fulfilling the ASAS axSpA criteria were included. Radiographs and MRI of the sacroiliac joints (SIJ) and spine were obtained at baseline, 1, 2 and 5 years. Each image was scored by 2 or 3 readers in 3 separate 'reading-waves'. The rate of change of outcomes measuring spinal and SIJ inflammation (e.g. SPARCC score) and structural damage on MRI (e.g. ≥3 fatty lesions) and radiographs (e.g. mNY grading) was assessed using multilevel generalized estimating equations (GEE) models (taking all readers and waves into account). To allow comparisons across outcomes, rates were standardized (difference between the individual's value and the population mean divided by the standard deviation). RESULTS: In total, 345 patients were included. Inflammation on MRI-SIJ (standardized rate range: -0.278; -0.441) was more sensitive to change compared to spinal inflammation (range: -0.030; -0.055). Structural damage in the SIJ showed a higher standardized rate of change on MRI-SIJ (range: 0.015-0.274) compared to X-SIJ (range: 0.043-0.126). MRI-SIJ damage defined by ≥3 fatty lesions showed the highest sensitivity to change (0.274). Spinal structural damage slowly progressed over time with no meaningful difference between radiographic (range: 0.037-0.043) and MRI structural outcomes (range: 0.008-0.027). CONCLUSION: Structural damage assessed in pelvic radiographs has low sensitivity to change, while fatty lesions detected on MRI-SIJ are a promising alternative. In contrast, MRI-spine is not better than X-spine in detecting structural changes in early axSpA patients.en
dc.description.versionpublishersversion
dc.description.versionpublished
dc.format.extent201524
dc.identifier.doi10.1002/acr.24459
dc.identifier.issn2151-464X
dc.identifier.otherPURE: 26054924
dc.identifier.otherPURE UUID: 73863897-61bb-4a64-abd6-3b0bd82edc97
dc.identifier.otherPubMed: 32976683
dc.identifier.otherScopus: 85123500298
dc.identifier.otherWOS: 000741460800001
dc.identifier.urihttp://hdl.handle.net/10362/132210
dc.language.isoeng
dc.peerreviewedyes
dc.subjectAxial spondyloarthritis
dc.subjectimaging
dc.subjectsensitivity to change
dc.titleWhich imaging outcomes for axSpA are most sensitive to change?en
dc.title.subtitleA 5-Year analysis of The DESIR Cohorten
dc.typejournal article
degois.publication.firstPage251
degois.publication.issue2
degois.publication.lastPage258
degois.publication.titleArthritis Care & Research
degois.publication.volume74
dspace.entity.typePublication
person.familyNameSepriano
person.familyNameRamiro
person.givenNameAlexandre
person.givenNameSofia
person.identifier397398
person.identifier.ciencia-id5E1B-9976-5CE4
person.identifier.ciencia-idC513-D4F1-EEC3
person.identifier.orcid0000-0003-1954-0229
person.identifier.orcid0000-0002-8899-9087
person.identifier.scopus-author-id55266526300
rcaap.rightsopenAccess
relation.isAuthorOfPublicationd87df0c7-841b-4648-a99e-296348e2e286
relation.isAuthorOfPublication9853406a-2641-440d-a8b1-a516bdb6f32f
relation.isAuthorOfPublication.latestForDiscoveryd87df0c7-841b-4648-a99e-296348e2e286

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