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Novel Experimental Setup for Ascending Thoracic Aortic Aneurysm Inflation Testing

2026-02Artigo científico Acesso aberto
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dc.contributor.authorVasconcelos, Hugo Mesquita
dc.contributor.authorAzevedo, Daniela
dc.contributor.authorValente, Rodrigo
dc.contributor.authorSousa, Pedro J.
dc.contributor.authorDomingues, Tiago
dc.contributor.authorDias, Susana
dc.contributor.authorLopes, Rogério F.F.
dc.contributor.authorCipriano, Gonçalo P.
dc.contributor.authorTomás, António
dc.contributor.authorTavares, Paulo J.
dc.contributor.authorXavier, José
dc.contributor.authorMoreira, Pedro M.G.P.
dc.contributor.institutionDEMI - Departamento de Engenharia Mecânica e Industrial
dc.contributor.institutionUNIDEMI - Unidade de Investigação e Desenvolvimento em Engenharia Mecânica e Industrial
dc.contributor.pblMDPI AG
dc.date.accessioned2026-07-14T14:45:02Z
dc.date.available2026-07-14T14:45:02Z
dc.date.issued2026-02
dc.descriptionPublisher Copyright: © 2026 by the authors.
dc.description.abstractDegraded mechanical properties in the aortic wall can lead to the formation of aortic aneurysms, potentially resulting in life-threatening ruptures. Current diagnostic criteria using maximum aortic diameter often fail to predict this critical moment, underscoring the need for more accurate patient-based prediction methods. A hospital-compatible experimental apparatus was designed for quasi-static ex vivo inflation testing of intact Ascending Thoracic Aortic Aneurysm (ATAA) specimens with 360° full-field three-dimensional digital image correlation (3D-DIC). Given hospital handling constraints, liquid pressurization was not feasible; instead, pressure was applied via a balloon-driven pneumatic system, and synchronized stereo imaging was used to measure surface displacement fields between 80 and 120 mmHg. The system was validated using a CT-derived ATAA silicone phantom. Full-field displacement measurements showed close agreement with finite element simulations, supporting the mechanical reliability of the apparatus and the repeatability of the measurement workflow. In addition, a frozen–thawed healthy porcine thoracic aorta was tested to demonstrate biological feasibility, particularly regarding the speckle application and DIC tracking, without aiming to extract tissue constitutive parameters. Overall, the setup provides a practical framework for acquiring full-field inflation-induced deformation data from intact aortic specimens in a hospital setting, enabling future studies on resected human ATAA tissue and model calibration that may contribute to more accurate methods for rupture prediction.en
dc.description.versionpublishersversion
dc.description.versionpublished
dc.format.extent18
dc.format.extent11418316
dc.identifier.doi10.3390/bioengineering13020199
dc.identifier.issn2306-5354
dc.identifier.otherPURE: 157527650
dc.identifier.otherPURE UUID: 7a4c2c90-0ec9-4420-82bd-d73ba244558b
dc.identifier.otherScopus: 105031487597
dc.identifier.urihttp://hdl.handle.net/10362/204513
dc.identifier.urlhttps://www.scopus.com/pages/publications/105031487597
dc.language.isoeng
dc.peerreviewedyes
dc.subjectaortic aneurysm mechanics
dc.subjectascending thoracic aortic aneurysm
dc.subjectfull-field displacement analysis
dc.subjectinflation testing
dc.subjectBioengineering
dc.subjectSDG 3 - Good Health and Well-being
dc.titleNovel Experimental Setup for Ascending Thoracic Aortic Aneurysm Inflation Testingen
dc.typejournal article
degois.publication.issue2
degois.publication.titleBioengineering
degois.publication.volume13
dspace.entity.typePublication
rcaap.rightsopenAccess

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