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Did psychosocial status, sociodemographics and smoking status affect non-attendance in control participants in the Danish Lung Cancer Screening Trial?

2020-02-20Artigo científico Acesso aberto
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dc.contributor.authorMalmqvist, Jessica
dc.contributor.authorSiersma, Volkert
dc.contributor.authorThorsen, Hanne
dc.contributor.authorHeleno, Bruno
dc.contributor.authorHeleno, Bruno
dc.contributor.authorRasmussen, Jakob Fraes
dc.contributor.authorBrodersen, John
dc.contributor.institutionNOVA Medical School|Faculdade de Ciências Médicas (NMS|FCM)
dc.contributor.pblBMJ Publishing Group
dc.date.accessioned2020-03-06T23:32:22Z
dc.date.available2020-03-06T23:32:22Z
dc.date.issued2020-02-20
dc.description© Author(s) (or their employer(s)) 2020. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ.
dc.description.abstractOBJECTIVES: We investigated if psychosocial status, sociodemographics and smoking status affected non-attendance in the control group in the randomised Danish Lung Cancer Screening Trial (DLCST). DESIGN AND SETTING: This study was an observational study nested in the DLCST. Due to large non-attendance in the control group in the second screening round we made an additional effort to collect questionnaire data from non-attenders in this group in the third screening round. We used a condition-specific questionnaire to assess psychosocial status. We analysed the differences in psychosocial status in the third and preceding rounds between non-attenders and attenders in the control group in multivariable linear regression models adjusted for sociodemographics and smoking status reported at baseline. Differences in sociodemographics and smoking status were analysed with χ2 tests (categorical variables) and t-tests (continuous variables). PRIMARY OUTCOME MEASURE: Primary outcome was psychosocial status. PARTICIPANTS: All control persons participating in the third screening round in the DLCST were included. RESULTS: Non-attenders in the third round had significantly worse psychosocial status than attenders in the scales: 'behaviour' 0.77 (99% CI 0.18 to 1.36), 'self-blame' 0.59 (99% CI 0.14 to 1.04), 'focus on airway symptoms' 0.22 (99% CI 0.08 to 0.36), 'stigmatisation' 0.51 (99% CI 0.16 to 0.86), 'introvert' 0.56 (99% CI 0.23 to 0.89) and 'harms of smoking' 0.35 (99% CI 0.11 to 0.59). Moreover, non-attenders had worse scores than attendees in the preceding screening rounds. Non-attenders also reported worse sociodemographics at baseline. CONCLUSIONS: Non-attenders had a significantly worse psychosocial status and worse sociodemographics compared with attenders. The results of our study contribute with evidence of non-response and attrition driven by psychosocial status, which in turn may be influenced by the screening intervention itself. This can be used to adjust cancer screening trial results for bias due to differential non-attendance. TRIAL REGISTRATION NUMBER: Clinicaltrials.gov Protocol Registration System (NCT00496977).en
dc.description.versionpublishersversion
dc.description.versionpublished
dc.format.extent424217
dc.identifier.doi10.1136/bmjopen-2019-030871
dc.identifier.issn2044-6055
dc.identifier.otherPURE: 17161655
dc.identifier.otherPURE UUID: 74fa9e2c-5c5a-4747-8e1d-145ca2956fbe
dc.identifier.otherPubMed: 32086352
dc.identifier.otherScopus: 85079824432
dc.identifier.otherORCID: /0000-0002-3943-1858/work/70243647
dc.identifier.otherWOS: 000527786700025
dc.identifier.urihttp://hdl.handle.net/10362/93932
dc.language.isoeng
dc.peerreviewedyes
dc.subjectbias
dc.subjectlung neoplasms
dc.subjectmass screening
dc.subjectpatient dropout
dc.subjectSDG 3 - Good Health and Well-being
dc.titleDid psychosocial status, sociodemographics and smoking status affect non-attendance in control participants in the Danish Lung Cancer Screening Trial?en
dc.title.subtitleA nested observational studyen
dc.typejournal article
degois.publication.issue2
degois.publication.titleBMJ Open
degois.publication.volume10
dspace.entity.typePublication
person.familyNameHeleno
person.givenNameBruno
person.identifier.ciencia-id8B1D-AC7D-5CB2
person.identifier.orcid0000-0002-3943-1858
person.identifier.scopus-author-id54937604600
rcaap.rightsopenAccess
relation.isAuthorOfPublication2a89b92b-0b51-4df1-911c-da2e71efae1b
relation.isAuthorOfPublication.latestForDiscovery2a89b92b-0b51-4df1-911c-da2e71efae1b

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