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Supramolecular engineering of micellar systems

2024-09-15Artigo científico Acesso aberto
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dc.contributor.authorGómez-González, Borja
dc.contributor.authorBasílio, Nuno
dc.contributor.authorVaz, Belén
dc.contributor.authorGóñez, Karen V.
dc.contributor.authorPérez-Lorenzo, Moisés
dc.contributor.authorGarcía-Río, Luis
dc.contributor.institutionLAQV@REQUIMTE
dc.contributor.institutionDQ - Departamento de Química
dc.contributor.pblElsevier
dc.date.accessioned2024-10-29T00:35:25Z
dc.date.available2024-10-29T00:35:25Z
dc.date.issued2024-09-15
dc.descriptionFunding Information: This work was funded by Ministerio de Ciencia e Innovación (PID2020-113704RB-I00), Xunta de Galicia (Centro Singular de Investigación de Galicia-Accreditation 2019-2022 ED431G 2019/06, ED431C 2022/24, ED431C 2021/45, and 001_IN853D_2022). K.V.G. acknowledges the founding of the Mestrelab Research Center (CIM) through the support of the Galician Innovation Agency (GAIN). Publisher Copyright: © 2024 The Author(s)
dc.description.abstractIn the quest for enhanced drug delivery systems, the combination of supramolecular receptors and surfactants represents a promising step toward developing innovative and highly efficient nanocarriers. This research highlights the paramount advantages of synergizing these elements, focusing on the manipulation of the self-assembly, charge, and polarity of the hybrid nanostructures resulting from merging these building blocks. In this vein, this work reveals that the integration of hexamethylated p-sulfonatocalix[6]arene (SC6A) and dodecyltrimethylammonium bromide (DTAB) offers significant advantages over those colloidal nanostructures stemming from the use of surfactant alone. These include the ability to stimulate early self-assembly, thereby facilitating the formation of stable nanocarriers, even in high-dilution scenarios. Additionally, the electrostatic balance established within the macrocycle-surfactant host–guest complexes can be harnessed to finely adjust the charge of the hydrophilic micellar corona. This holds great promise for modulating the bio-interaction capabilities of nanocarriers. Furthermore, the inclusion of the macrocycle in the colloidal structure induces significant alterations in the arrangement of low-molecular-weight surfactants. This leads to a significant transformation in the hydrophobic properties of the micellar core, which can be exploited to tailor this microenvironment to match the lipophilicity of specific drugs. In this regard, our findings reveal that while conventional DTAB micelles generally replicate the polarity of a solvent with a dielectric constant of 37.7, engineered SC6A-DTAB aggregates demonstrate a capability to reach a polarity akin to a solvent with dielectric constant of 17.5. This spectrum of hydrophobicities within the micellar core represents a significant advancement and opens up new possibilities for drug delivery applications.en
dc.description.versionpublishersversion
dc.description.versionpublished
dc.format.extent8
dc.format.extent4362140
dc.identifier.doi10.1016/j.molliq.2024.125675
dc.identifier.issn0167-7322
dc.identifier.otherPURE: 100220467
dc.identifier.otherPURE UUID: c4af4ea6-a9db-42c1-99d8-f0a501ff8d3a
dc.identifier.otherScopus: 85200230569
dc.identifier.otherWOS: 001289701100001
dc.identifier.urihttp://hdl.handle.net/10362/174208
dc.identifier.urlhttps://www.scopus.com/pages/publications/85200230569
dc.language.isoeng
dc.peerreviewedyes
dc.relationinfo:eu-repo/grantAgreement/FCT/CEEC IND 2017/CEECIND%2F00466%2F2017%2FCP1462%2FCT0013/PT
dc.relationNot Available
dc.relationinfo:eu-repo/grantAgreement/FCT/Concurso de avaliação no âmbito do Programa Plurianual de Financiamento de Unidades de I&D (2017%2F2018) - Financiamento Programático/UIDP%2F50006%2F2020/PT
dc.subjectEnvironment-sensitive probe
dc.subjectMacrocyclic receptor
dc.subjectNanocarrier design
dc.subjectSelf-assembly
dc.subjectSupramolecular micelle
dc.subjectElectronic, Optical and Magnetic Materials
dc.subjectAtomic and Molecular Physics, and Optics
dc.subjectCondensed Matter Physics
dc.subjectSpectroscopy
dc.subjectPhysical and Theoretical Chemistry
dc.subjectMaterials Chemistry
dc.titleSupramolecular engineering of micellar systemsen
dc.title.subtitlePrecision control on self-assembly, polarity, and charge for enhanced nanocarrier designen
dc.typejournal article
degois.publication.titleJournal of Molecular Liquids
degois.publication.volume410
dspace.entity.typePublication
oaire.awardNumberCEECIND/00466/2017/CP1462/CT0013
oaire.awardNumberUIDB/50006/2020
oaire.awardNumberUIDP/50006/2020
oaire.awardTitleNot Available
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/CEEC IND 2017/CEECIND%2F00466%2F2017%2FCP1462%2FCT0013/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/Concurso de avaliação no âmbito do Programa Plurianual de Financiamento de Unidades de I&D (2017%2F2018) - Financiamento Base/UIDB%2F50006%2F2020/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/Concurso de avaliação no âmbito do Programa Plurianual de Financiamento de Unidades de I&D (2017%2F2018) - Financiamento Programático/UIDP%2F50006%2F2020/PT
oaire.fundingStreamCEEC IND 2017
oaire.fundingStreamConcurso de avaliação no âmbito do Programa Plurianual de Financiamento de Unidades de I&D (2017/2018) - Financiamento Base
oaire.fundingStreamConcurso de avaliação no âmbito do Programa Plurianual de Financiamento de Unidades de I&D (2017/2018) - Financiamento Programático
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
rcaap.rightsopenAccess
relation.isProjectOfPublication2f49aaab-813e-4034-9d8d-67553a970bd6
relation.isProjectOfPublication186df1fb-72e1-4b5e-bb56-1760cf233cbe
relation.isProjectOfPublicationae403dd6-3940-45dd-a7c4-04c6bec15552
relation.isProjectOfPublication.latestForDiscovery186df1fb-72e1-4b5e-bb56-1760cf233cbe

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