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Bioelectronic modulation of carotid sinus nerve to treat type 2 diabetes

2024Recensão Acesso aberto
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dc.contributor.authorConde, Silvia V.
dc.contributor.authorV Conde, Silvia
dc.contributor.authorSacramento, Joana F.
dc.contributor.authorZinno, Ciro
dc.contributor.authorMazzoni, Alberto
dc.contributor.authorMicera, Silvestro
dc.contributor.authorGuarino, Maria P.
dc.contributor.institutionNOVA Medical School|Faculdade de Ciências Médicas (NMS|FCM)
dc.contributor.institutioniNOVA4Health - pólo NMS
dc.contributor.pblFrontiers Media
dc.date.accessioned2024-05-07T00:31:11Z
dc.date.available2024-05-07T00:31:11Z
dc.date.issued2024
dc.descriptionPublisher Copyright: Copyright © 2024 Conde, Sacramento, Zinno, Mazzoni, Micera and Guarino.
dc.description.abstractBioelectronic medicine are an emerging class of treatments aiming to modulate body nervous activity to correct pathological conditions and restore health. Recently, it was shown that the high frequency electrical neuromodulation of the carotid sinus nerve (CSN), a small branch of the glossopharyngeal nerve that connects the carotid body (CB) to the brain, restores metabolic function in type 2 diabetes (T2D) animal models highlighting its potential as a new therapeutic modality to treat metabolic diseases in humans. In this manuscript, we review the current knowledge supporting the use of neuromodulation of the CSN to treat T2D and discuss the future perspectives for its clinical application. Firstly, we review in a concise manner the role of CB chemoreceptors and of CSN in the pathogenesis of metabolic diseases. Secondly, we describe the findings supporting the potential therapeutic use of the neuromodulation of CSN to treat T2D, as well as the feasibility and reversibility of this approach. A third section is devoted to point up the advances in the neural decoding of CSN activity, in particular in metabolic disease states, that will allow the development of closed-loop approaches to deliver personalized and adjustable treatments with minimal side effects. And finally, we discuss the findings supporting the assessment of CB activity in metabolic disease patients to screen the individuals that will benefit therapeutically from this bioelectronic approach in the future.en
dc.description.versionpublishersversion
dc.description.versionpublished
dc.format.extent2146083
dc.identifier.doi10.3389/fnins.2024.1378473
dc.identifier.issn1662-4548
dc.identifier.otherPURE: 89404537
dc.identifier.otherPURE UUID: bb7a71e3-b4d7-4a58-b1d6-88beaf5000c3
dc.identifier.otherScopus: 85190769217
dc.identifier.otherWOS: 001204937100001
dc.identifier.otherPubMed: 38646610
dc.identifier.urihttp://hdl.handle.net/10362/167064
dc.identifier.urlhttps://www.scopus.com/pages/publications/85190769217
dc.language.isoeng
dc.peerreviewedyes
dc.subjectbioelectronic medicine
dc.subjectcarotid body
dc.subjectcarotid sinus nerve
dc.subjectneuromodulation
dc.subjecttype 2 diabetes
dc.subjectGeneral Neuroscience
dc.subjectSDG 3 - Good Health and Well-being
dc.titleBioelectronic modulation of carotid sinus nerve to treat type 2 diabetesen
dc.title.subtitlecurrent knowledge and future perspectivesen
dc.typereview
degois.publication.titleFrontiers in Neuroscience
degois.publication.volume18
dspace.entity.typePublication
person.familyNameVilares Conde
person.givenNameSilvia
person.identifier154176
person.identifier.ciencia-id561E-CF29-600A
person.identifier.orcid0000-0002-5920-5700
person.identifier.scopus-author-id7004283202
rcaap.rightsopenAccess
relation.isAuthorOfPublication898e99d8-61a5-44bc-878a-5e1ac44ca37c
relation.isAuthorOfPublication.latestForDiscovery898e99d8-61a5-44bc-878a-5e1ac44ca37c

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