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Aedes aegypti on Madeira Island (Portugal): genetic variation of a recently introduced dengue vector

2013-01-01Artigo científico Acesso aberto
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dc.contributor.authorSeixas, Gonçalo
dc.contributor.authorSalgueiro, Patrícia
dc.contributor.authorSilva, Ana
dc.contributor.authorCampos, Melina
dc.contributor.authorSpenassatto , Carine
dc.contributor.authorReyes_Lugo, Matias
dc.contributor.authorNovo, Maria Teresa Lourenço Marques
dc.contributor.authorRibolla, Paulo
dc.contributor.authorPinto, João Pedro Soares da Silva
dc.contributor.authorSousa, Carla Alexandra Gama Carrilho da Costa
dc.contributor.institutionInstituto de Higiene e Medicina Tropical (IHMT)
dc.contributor.institutionCentro de Malária e outras Doenças Tropicais (CMDT)
dc.contributor.institutionUnidade de Parasitologia e Microbiologia Médicas (UPMM)
dc.contributor.pblMemorias Do Instituto Oswaldo Cruz / Instituto Oswaldo Cruz, Ministério da Saúde
dc.date.accessioned2021-05-04T22:31:54Z
dc.date.available2021-05-04T22:31:54Z
dc.date.issued2013-01-01
dc.description.abstractThe increasing population of Aedes aegypti mosquitoes on Madeira Island (Portugal) resulted in the first autochthonous dengue outbreak, which occurred in October 2012. Our study establishes the first genetic evaluation based on the mitochondrial DNA (mtDNA) genes [cytochrome oxidase subunit I (COI) and NADH dehydrogenase subunit 4 (ND4)] and knockdown resistance ( kdr ) mutations exploring the colonisation history and the genetic diversity of this insular vector population. We included mosquito populations from Brazil and Venezuela in the analysis as putative geographic sources. The Ae. aegypti population from Madeira showed extremely low mtDNA genetic variability, with a single haplotype for COI and ND4. We also detected the presence of two important kdr mutations and the quasi-fixation of one of these mutations (F1534C). These results are consistent with a unique recent founder event that occurred on the island of Ae. aegypti mosquitoes that carry kdr mutations associated with insecticide resistance. Finally, we also report the presence of the F1534C kdr mutation in the Brazil and Venezuela populations. To our knowledge, this is the first time this mutation has been found in South American Ae. aegypti mosquitoes. Given the present risk of Ae. aegypti re-invading continental Europe from Madeira and the recent dengue outbreaks on the island, this information is important to plan surveillance and control measures.en
dc.description.versionpublishersversion
dc.description.versionpublished
dc.format.extent529161
dc.identifier.doi10.1590/0074-0276130386
dc.identifier.issn1678-8060
dc.identifier.otherPURE: 177999
dc.identifier.otherPURE UUID: d9d71183-1b7a-44ce-b0ca-418fddfdfd6e
dc.identifier.otherresearchoutputwizard: 44362
dc.identifier.otherPubMed: 24473797
dc.identifier.otherScopus: 84894702352
dc.identifier.otherWOS: 000330037800002
dc.identifier.otherORCID: /0000-0001-8628-3651/work/48637795
dc.identifier.otherORCID: /0000-0001-8572-7708/work/49741597
dc.identifier.otherORCID: /0000-0003-0484-3374/work/55386097
dc.identifier.urihttp://hdl.handle.net/10362/116957
dc.language.isoeng
dc.peerreviewedyes
dc.subjectAedes aegypti
dc.subjectdengue
dc.subjectknockdown resistance
dc.subjectmtDNA
dc.subjectGenetics
dc.subjectEcology, Evolution, Behavior and Systematics
dc.subjectInsect Science
dc.subjectInfectious Diseases
dc.subjectSDG 3 - Good Health and Well-being
dc.subjectSDG 15 - Life on Land
dc.titleAedes aegypti on Madeira Island (Portugal): genetic variation of a recently introduced dengue vectoren
dc.typejournal article
degois.publication.firstPage3
degois.publication.issueSuppl. 1
degois.publication.lastPage10
degois.publication.titleMemórias do Instituto Oswaldo Cruz
degois.publication.volume108
dspace.entity.typePublication
rcaap.rightsopenAccess

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