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Brain dysfunction in tubular and tubulointerstitial kidney diseases

2022-01Artigo científico Acesso aberto
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dc.contributor.authorViggiano, Davide
dc.contributor.authorBruchfeld, Annette
dc.contributor.authorCarriazo, Sol
dc.contributor.authorde Donato, Antonio
dc.contributor.authorEndlich, Nicole
dc.contributor.authorFerreira, Ana Carina
dc.contributor.authorFigurek, Andreja
dc.contributor.authorFouque, Denis
dc.contributor.authorFranssen, Casper F.M.
dc.contributor.authorGiannakou, Konstantinos
dc.contributor.authorGoumenos, Dimitrios
dc.contributor.authorHoorn, Ewout J.
dc.contributor.authorNitsch, Dorothea
dc.contributor.authorOrtiz, Alberto
dc.contributor.authorPešić, Vesna
dc.contributor.authorRastenyté, Daiva
dc.contributor.authorSoler, Maria José
dc.contributor.authorRroji, Merita
dc.contributor.authorTrepiccione, Francesco
dc.contributor.authorUnwin, Robert J.
dc.contributor.authorWagner, Carsten A.
dc.contributor.authorWieçek, Andrzej
dc.contributor.authorZacchia, Miriam
dc.contributor.authorZoccali, Carmine
dc.contributor.authorCapasso, Giovambattista
dc.contributor.institutionNOVA Medical School|Faculdade de Ciências Médicas (NMS|FCM)
dc.contributor.pblEuropean Renal Association - European Dialysis and Transplant Association (ERA-EDTA) | Oxford University Press
dc.date.accessioned2022-01-27T03:27:12Z
dc.date.available2022-01-27T03:27:12Z
dc.date.issued2022-01
dc.descriptionFunding: This article is published as part of a supplement financially supported by the COST Action CA19127-Cognitive Decline in Nephro-Neurology: European Cooperative Target (CONNECT).
dc.description.abstractKidney function has two important elements: glomerular filtration and tubular function (secretion and reabsorption). A persistent decrease in glomerular filtration rate (GFR), with or without proteinuria, is diagnostic of chronic kidney disease (CKD). While glomerular injury or disease is a major cause of CKD and usually associated with proteinuria, predominant tubular injury, with or without tubulointerstitial disease, is typically non-proteinuric. CKD has been linked with cognitive impairment, but it is unclear how much this depends on a decreased GFR, altered tubular function or the presence of proteinuria. Since CKD is often accompanied by tubular and interstitial dysfunction, we explore here for the first time the potential role of the tubular and tubulointerstitial compartments in cognitive dysfunction. To help address this issue we selected a group of primary tubular diseases with preserved GFR in which to review the evidence for any association with brain dysfunction. Cognition, mood, neurosensory and motor disturbances are not well characterized in tubular diseases, possibly because they are subclinical and less prominent than other clinical manifestations. The available literature suggests that brain dysfunction in tubular and tubulointerstitial diseases is usually mild and is more often seen in disorders of water handling. Brain dysfunction may occur when severe electrolyte and water disorders in young children persist over a long period of time before the diagnosis is made. We have chosen Bartter and Gitelman syndromes and nephrogenic diabetes insipidus as examples to highlight this topic. We discuss current published findings, some unanswered questions and propose topics for future research.en
dc.description.versionpublishersversion
dc.description.versionpublished
dc.format.extent1441253
dc.identifier.doi10.1093/ndt/gfab276
dc.identifier.issn0931-0509
dc.identifier.otherPURE: 36396517
dc.identifier.otherPURE UUID: e3246759-0782-4f01-9c0f-3d0add1c0f1b
dc.identifier.otherScopus: 85123025125
dc.identifier.otherPubMed: 34792176
dc.identifier.otherWOS: 000740945100006
dc.identifier.urihttp://hdl.handle.net/10362/131651
dc.identifier.urlhttps://www.scopus.com/pages/publications/85123025125
dc.language.isoeng
dc.peerreviewedyes
dc.subjectbrain
dc.subjectchronic kidney disease
dc.subjectcognitive function
dc.subjectelectrolyte
dc.subjecttubulointerstitial
dc.subjectNephrology
dc.subjectTransplantation
dc.subjectSDG 3 - Good Health and Well-being
dc.titleBrain dysfunction in tubular and tubulointerstitial kidney diseasesen
dc.typejournal article
degois.publication.firstPageii46
degois.publication.issue2
degois.publication.lastPageii55
degois.publication.titleNephrology Dialysis Transplantation
degois.publication.volume37
dspace.entity.typePublication
rcaap.rightsopenAccess

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