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Gold nanoparticles for vectorization of nucleic acids for cancer therapeutics

2020-08Recensão Acesso aberto
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dc.contributor.authorFerreira, Daniela
dc.contributor.authorFontinha, David
dc.contributor.authorMartins, Catarina
dc.contributor.authorPires, David
dc.contributor.authorFernandes, Alexandra R.
dc.contributor.authorBaptista, Pedro V.
dc.contributor.institutionDCV - Departamento de Ciências da Vida
dc.contributor.institutionUCIBIO - Applied Molecular Biosciences Unit
dc.contributor.pblMDPI - Multidisciplinary Digital Publishing Institute
dc.date.accessioned2022-01-20T03:30:02Z
dc.date.available2022-01-20T03:30:02Z
dc.date.issued2020-08
dc.description
dc.description.abstractCancer remains a complex medical challenge and one of the leading causes of death worldwide. Nanomedicines have been proposed as innovative platforms to tackle these complex diseases, where the combination of several treatment strategies might enhance therapy success. Among these nanomedicines, nanoparticle mediated delivery of nucleic acids has been put forward as key instrument to modulate gene expression, be it targeted gene silencing, interference RNA mechanisms and/or gene edition. These novel delivery systems have strongly relied on nanoparticles and, in particular, gold nanoparticles (AuNPs) have paved the way for efficient delivery systems due to the possibility to fine-tune their size, shape and surface properties, coupled to the ease of functionalization with different biomolecules. Herein, we shall address the different molecular tools for modulation of expression of oncogenes and tumor suppressor genes and discuss the state-of-the-art of AuNP functionalization for nucleic acid delivery both in vitro and in vivo models. Furthermore, we shall highlight the clinical applications of these spherical AuNP based conjugates for gene delivery, current challenges, and future perspectives in nanomedicine.en
dc.description.versionpublishersversion
dc.description.versionpublished
dc.format.extent1168934
dc.identifier.doi10.3390/molecules25153489
dc.identifier.issn1420-3049
dc.identifier.otherPURE: 28939536
dc.identifier.otherPURE UUID: 2a2caa70-f529-4c59-bf36-ccaf728a34a7
dc.identifier.otherScopus: 85089130785
dc.identifier.otherPubMed: 32751935
dc.identifier.otherPubMedCentral: PMC7435825
dc.identifier.otherWOS: 000559115700001
dc.identifier.urihttp://hdl.handle.net/10362/131178
dc.identifier.urlhttps://www.scopus.com/pages/publications/85089130785
dc.language.isoeng
dc.peerreviewedyes
dc.relationinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/UIDB%2F04378%2F2020/PT
dc.relationApplied Molecular Biosciences Unit
dc.relationDetection and Characterisation of Nanoparticles Using Solid-State Nanopores: A Single Molecule Approach
dc.relationinfo:eu-repo/grantAgreement/FCT/3599-PPCDT/M-ERA-NET2%2F0008%2F2016/PT
dc.subjectGene editing
dc.subjectGene silencing
dc.subjectGold nanoparticles
dc.subjectNanomedicine
dc.subjectTherapeutic nucleic acid
dc.subjectAnalytical Chemistry
dc.subjectChemistry (miscellaneous)
dc.subjectMolecular Medicine
dc.subjectPharmaceutical Science
dc.subjectDrug Discovery
dc.subjectPhysical and Theoretical Chemistry
dc.subjectOrganic Chemistry
dc.subjectSDG 3 - Good Health and Well-being
dc.titleGold nanoparticles for vectorization of nucleic acids for cancer therapeuticsen
dc.typereview
degois.publication.issue15
degois.publication.titleMolecules
degois.publication.volume25
dspace.entity.typePublication
oaire.awardNumberUIDB/04378/2020
oaire.awardNumberPTDC/NAN-MAT/31100/2017
oaire.awardNumberM-ERA-NET2/0008/2016
oaire.awardTitleApplied Molecular Biosciences Unit
oaire.awardTitleDetection and Characterisation of Nanoparticles Using Solid-State Nanopores: A Single Molecule Approach
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/UIDB%2F04378%2F2020/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/3599-PPCDT/PTDC%2FNAN-MAT%2F31100%2F2017/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/3599-PPCDT/M-ERA-NET2%2F0008%2F2016/PT
oaire.fundingStream6817 - DCRRNI ID
oaire.fundingStream3599-PPCDT
oaire.fundingStream3599-PPCDT
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
rcaap.rightsopenAccess
relation.isProjectOfPublicatione07cf232-4705-4b5b-b2c4-af8f25311076
relation.isProjectOfPublication3bd67e0b-5eb6-4a72-8563-46bdce936d44
relation.isProjectOfPublication82bb3e81-948f-40b8-bfc4-d431daedea36
relation.isProjectOfPublication.latestForDiscovery3bd67e0b-5eb6-4a72-8563-46bdce936d44

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