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Preliminary assays towards melanoma cells using phototherapy with gold-based nanomaterials

2020-08-05Artigo científico Acesso aberto
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dc.contributor.authorLopes, Joana
dc.contributor.authorCoelho, João Miguel Pinto
dc.contributor.authorVieira, Pedro Manuel Cardoso
dc.contributor.authorViana, Ana Silveira
dc.contributor.authorGaspar, Maria Manuela
dc.contributor.authorReis, Catarina Pinto
dc.contributor.institutionDF – Departamento de Física
dc.contributor.pblMDPI AG
dc.date.accessioned2021-07-15T22:21:19Z
dc.date.available2021-07-15T22:21:19Z
dc.date.issued2020-08-05
dc.descriptionUIDB/00645/2020 UID/DTP/04138/2019 PTDC/MED-QUI/31721/2017 SFRH/BD/148044/2019
dc.description.abstractCancer like melanoma is a complex disease, for which standard therapies have significant adverse side effects that in most cases are ineffective and highly unspecific. Thus, a new paradigm has come with the need of achieving alternative (less invasive) and effective therapies. In this work, biocompatible gold nanoparticles (GNPs) coated with hyaluronic acid and oleic acid were prepared and characterized in terms of size, morphology and cytotoxicity in the presence of Saccharomyces cerevisiae, and two cell lines, the keratinocytes (healthy skin cells, HaCat) and the melanoma cells (B16F10). Results showed that these GNPs absorb within the near-infrared region (750–1400 nm), in the optical therapeutic window (from 650 to 1300 nm), in contrast to other commercial gold nanoparticles, which enables light to penetrate into deep skin layers. A laser emitting in this region was applied and its effect also analyzed. The coated GNPs showed a spherical morphology with a mean size of 297 nm without cytotoxic effects towards yeast and tested cell lines. Nevertheless, after laser irradiation, a reduction of 20% in B16F10 cell line viability was observed. In summary, this work appears to be a promising strategy for the treatment of non-metastatic melanoma or other superficial tumors.en
dc.description.versionpublishersversion
dc.description.versionpublished
dc.format.extent14
dc.format.extent4204357
dc.identifier.doi10.3390/nano10081536
dc.identifier.issn2079-4991
dc.identifier.otherPURE: 32581306
dc.identifier.otherPURE UUID: 2366013e-8b8c-464a-8955-67c88b58606f
dc.identifier.otherScopus: 85090634663
dc.identifier.otherPubMed: 32764377
dc.identifier.otherPubMedCentral: PMC7466595
dc.identifier.otherWOS: 000564843100001
dc.identifier.urihttp://hdl.handle.net/10362/121083
dc.identifier.urlhttps://www.scopus.com/pages/publications/85090634663
dc.language.isoeng
dc.peerreviewedyes
dc.subjectBioproduction
dc.subjectExperimental results
dc.subjectGold nanoparticles
dc.subjectIn vitro models
dc.subjectLaser photothermal therapy
dc.subjectMelanoma
dc.subjectGeneral Chemical Engineering
dc.subjectGeneral Materials Science
dc.subjectSDG 3 - Good Health and Well-being
dc.titlePreliminary assays towards melanoma cells using phototherapy with gold-based nanomaterialsen
dc.typejournal article
degois.publication.firstPage1
degois.publication.issue8
degois.publication.lastPage14
degois.publication.titleNanomaterials
degois.publication.volume10
dspace.entity.typePublication
rcaap.rightsopenAccess

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