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Marine Antimicrobial Peptides

2025-08Recensão Acesso aberto
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dc.contributor.authorMagalhães, Rita
dc.contributor.authorMil-Homens, Dalila
dc.contributor.authorCruz, Sónia
dc.contributor.authorOliveira, Manuela
dc.contributor.institutionInstituto de Tecnologia Química e Biológica António Xavier (ITQB)
dc.contributor.pblMDPI - Multidisciplinary Digital Publishing Institute
dc.date.accessioned2026-04-06T19:51:01Z
dc.date.available2026-04-06T19:51:01Z
dc.date.issued2025-08
dc.descriptionFunding Information: This research was funded by the Portuguese Foundation for Science and Technology (FCT) under the fellowship 2024.05947.BD to R.M., grant 2020.03278.CEECIND to S.C. (https://doi.org/10.54499/2020.03278.CEECIND/CP1589/CT0012), and under CESAM project/grant UID/50006 + LA/P/0094/2020 (doi.org/10.54499/LA/P/0094/2020). S.C. acknowledges further support by the European Research Council (ERC) under the European Union\u2019s Horizon 2020 research and innovation program, grant agreement no. 949880 (https://doi.org/10.3030/949880). Publisher Copyright: © 2025 by the authors.
dc.description.abstractThe global rise in antimicrobial resistance poses a major threat to public health, with multidrug-resistant bacterial infections expected to surpass cancer in mortality by 2050. As traditional antibiotic pipelines stagnate, novel therapeutic alternatives are critically needed. Antimicrobial peptides (AMPs), particularly those derived from marine organisms, have emerged as promising antimicrobial candidates due to their broad-spectrum activity, structural diversity, and distinctive mechanisms of action. Unlike conventional antibiotics, AMPs can disrupt microbial membranes, inhibit biofilm formation, and even modulate immune responses, making them highly effective against resistant bacteria. This review highlights the potential of marine AMPs as next-generation therapeutics, emphasizing their efficacy against multidrug-resistant pathogens and biofilm-associated infections. Furthermore, marine AMPs show promise in combating persister cells and disrupting quorum sensing pathways, offering new strategies for tackling chronic infections. Despite their potential, challenges such as production scalability and limited clinical validation remain; nevertheless, the use of new technologies and bioinformatic tools is accelerating the discovery and optimization of these peptides, paving the way for bypassing these challenges. This review consolidates current findings on marine AMPs, advocating for their continued exploration as viable tools in the fight against antimicrobial resistance.en
dc.description.versionpublishersversion
dc.description.versionpublished
dc.format.extent721199
dc.identifier.doi10.3390/antibiotics14080808
dc.identifier.issn2079-6382
dc.identifier.otherPURE: 130287753
dc.identifier.otherPURE UUID: a0d810ae-6d63-4239-9652-c4b3215413be
dc.identifier.otherScopus: 105014508344
dc.identifier.urihttp://hdl.handle.net/10362/202064
dc.identifier.urlhttps://www.scopus.com/pages/publications/105014508344
dc.language.isoeng
dc.peerreviewedyes
dc.subjectAMPs
dc.subjectantibiotic resistance
dc.subjectantibiotic tolerance
dc.subjectantimicrobial peptides
dc.subjectbiofilm
dc.subjectmarine
dc.subjectpersister cells
dc.subjectMicrobiology
dc.subjectBiochemistry
dc.subjectPharmacology, Toxicology and Pharmaceutics(all)
dc.subjectMicrobiology (medical)
dc.subjectPharmacology (medical)
dc.subjectInfectious Diseases
dc.subjectSDG 3 - Good Health and Well-being
dc.subjectSDG 14 - Life Below Water
dc.titleMarine Antimicrobial Peptidesen
dc.title.subtitleEmerging Strategies Against Multidrug-Resistant and Biofilm-Forming Bacteriaen
dc.typereview
degois.publication.issue8
degois.publication.titleAntibiotics
degois.publication.volume14
dspace.entity.typePublication
rcaap.rightsopenAccess

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