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Outcomes of cystoid macular edema following Descemet's membrane endothelial keratoplasty in a referral center for keratoplasty in Spain

2023-02-09Artigo científico Acesso aberto
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dc.contributor.authorMoura-Coelho, Nuno
dc.contributor.authorPapa-Vettorazzi, Renato
dc.contributor.authorSantiesteban-García, Imalvet
dc.contributor.authorDias-Santos, Arnaldo
dc.contributor.authorManero, Felicidad
dc.contributor.authorCunha, João Paulo
dc.contributor.authorGüell, José
dc.contributor.institutionNOVA Medical School|Faculdade de Ciências Médicas (NMS|FCM)
dc.contributor.pblNature Publishing Group
dc.date.accessioned2023-02-23T22:20:15Z
dc.date.available2023-02-23T22:20:15Z
dc.date.issued2023-02-09
dc.description.abstractThe aim of this study was to analyze the outcomes of eyes with visually significant cystoid macular œdema (vs-CMO) after Descemet membrane endothelial keratoplasty (DMEK) in a referral center for keratoplasty in Spain. We conducted a retrospective, single-surgeon case series of eyes that developed post-DMEK vs-CMO performed between January 2011 and December 2020. Data collected included: indication for DMEK; biometric data; ocular comorbidities; past medical history; time to detection of vs-CMO after DMEK (T, weeks); best-corrected visual acuity (BCVA, logMAR) and central retinal thickness (CRT, µm) at diagnosis of vs-CMO, after resolution of CMO, and at last follow-up; and management strategy. Main outcomes analyzed were incidence of vs-CMO, improvement in BCVA and CRT after treatment of vs-CMO. Of 291 consecutive DMEK surgeries, 14 eyes of 13 patients (4.8%) developed vs-CMO. Five patients (38.5%) had history of CMO, and 28.6% of eyes had ophthalmic comorbidities. Median (P25-P75) T was 4 (3-10) weeks. Treatment success was observed in 12/13 eyes (92.3%), two of which required second-line treatment. In successful cases (median time-to-resolution 3.0 (2.0-3.5) months), median BCVA improved from 0.60 (0.40-0.80) logMAR to 0.30 (0.15-0.40) logMAR (p = 0.002) after treatment, and median CRT improved from 582.5 (400.0-655.0) µm to 278.0 (258.0-294.0) µm (p = 0.005). In our study, we found a 4.8% rate of post-DMEK vs-CMO, with most cases occurring in the first 3 months after surgery. Good functional and anatomical outcomes are expected in most eyes, without treatment-related complications or implications in graft outcomes. Additional studies are encouraged to determine a standardized protocol for post-DMEK vs-CMO.en
dc.description.versionpublishersversion
dc.description.versionpublished
dc.format.extent1
dc.format.extent1132276
dc.identifier.doi10.1038/s41598-023-29127-5
dc.identifier.issn2045-2322
dc.identifier.otherPURE: 53592280
dc.identifier.otherPURE UUID: 0e53daf5-7d33-4a2a-996b-5eaad18482d3
dc.identifier.otherScopus: 85147786976
dc.identifier.otherPubMed: 36759529
dc.identifier.urihttp://hdl.handle.net/10362/149615
dc.identifier.urlhttps://www.scopus.com/pages/publications/85147786976
dc.language.isoeng
dc.peerreviewedyes
dc.subjectGeneral
dc.titleOutcomes of cystoid macular edema following Descemet's membrane endothelial keratoplasty in a referral center for keratoplasty in Spainen
dc.title.subtitleretrospective studyen
dc.typejournal article
degois.publication.firstPage
degois.publication.issue1
degois.publication.lastPage
degois.publication.titleScientific Reports
degois.publication.volume13
dspace.entity.typePublication
rcaap.rightsopenAccess

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