Logo do repositório
 
Publicação

Effect of mono- and dinuclear thiosemicarbazone platinacycles in the proliferation of a colorectal carcinoma cell line

2024-08-23Artigo científico Acesso aberto
Ver registo simples
dc.contributor.authorReigosa-Chamorro, Francisco
dc.contributor.authorCordeiro, Sandra
dc.contributor.authorPereira, M. Teresa
dc.contributor.authorFilipe, Beatriz
dc.contributor.authorBaptista, Pedro V.
dc.contributor.authorFernandes, Alexandra R.
dc.contributor.authorVila, José M.
dc.contributor.institutionUCIBIO - Applied Molecular Biosciences Unit
dc.contributor.institutionDCV - Departamento de Ciências da Vida
dc.contributor.pblRSC - Royal Society of Chemistry
dc.date.accessioned2025-03-10T21:09:17Z
dc.date.available2025-03-10T21:09:17Z
dc.date.issued2024-08-23
dc.descriptionThis work was also made possible thanks to the financial support received from the Xunta de Galicia (Galicia, Spain) under the Grupos de Referencia Competitiva Programme (project GRC2019/14). F. R. thanks the Spanish Ministry of Education (grant FPU15/07145). Publisher Copyright: © 2024 The Royal Society of Chemistry.
dc.description.abstractHerein, we describe the synthesis and characterization of a series of thiosemicarbazone platinacycles. Their activity towards HCT116 and A2780 cancer cell lines as well as normal fibroblasts was explored and conclusions about the influence of their structures were drawn based on the results. Ligands L1-3, tetranuclear compounds [Pt(L1-3)]4, [Pt(L1-3)(PPh3)], and [Pt(L1-L3)2{Ph2P(CH2)4PPh2}], and phosphine derivatives, were deemed unpromising owing to their lack of activity. However, mono-coordinated diphosphine complexes [Pt(L1-L3)(Ph2PCH2PPh2-P)] showed high selectivity and low IC50 values, and their antiproliferative activity was further studied. The three studied derivatives 3a, 3b and 3c showed a fast internalization of HCT116 colorectal cancer cells with similar IC50 values, which induced a depolarization of mitochondrial membrane potential, with the subsequent triggering of apoptosis and autophagy in the case of 3c. In the case of compounds 3a and 3b, cell death mechanisms (extrinsic and intrinsic apoptosis, respectively) were triggered via the induction of reactive oxygen species (ROS). The three compounds were not toxic to a chicken embryo in vivo (after 48 h), and, importantly, showed an anti-angiogenic potential after exposure to the IC50 of compounds 3a, 3b and 3c.en
dc.description.versionpublishersversion
dc.description.versionepub_ahead_of_print
dc.format.extent16
dc.format.extent4868202
dc.identifier.doi10.1039/d4dt01490a
dc.identifier.issn1477-9226
dc.identifier.otherPURE: 102068359
dc.identifier.otherPURE UUID: fe438f66-0e4d-4568-a784-2bd2d981a6c7
dc.identifier.otherScopus: 85203181320
dc.identifier.otherWOS: 001304450400001
dc.identifier.otherPubMed: 39233530
dc.identifier.otherORCID: /0000-0001-5255-7095/work/179772444
dc.identifier.otherORCID: /0000-0003-2054-4438/work/179772579
dc.identifier.urihttp://hdl.handle.net/10362/180396
dc.identifier.urlhttps://www.scopus.com/pages/publications/85203181320
dc.identifier.urlhttps://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=nova_api&SrcAuth=WosAPI&KeyUT=WOS:001304450400001&DestLinkType=FullRecord&DestApp=WOS_CPL
dc.language.isoeng
dc.peerreviewedyes
dc.relationFunding Information: info:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/UIDP%2F04378%2F2020/PT
dc.relationinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/UIDB%2F04378%2F2020/PT
dc.relationApplied Molecular Biosciences Unit
dc.relationinfo:eu-repo/grantAgreement/FCT/OE/2021.08629.BD/PT
dc.subjectInorganic Chemistry
dc.subjectSDG 3 - Good Health and Well-being
dc.titleEffect of mono- and dinuclear thiosemicarbazone platinacycles in the proliferation of a colorectal carcinoma cell lineen
dc.typejournal article
degois.publication.titleDalton Transactions
dspace.entity.typePublication
oaire.awardNumberUIDB/04378/2020
oaire.awardNumberLA/P/0140/2020
oaire.awardNumber2021.08629.BD
oaire.awardTitleApplied Molecular Biosciences Unit
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/UIDB%2F04378%2F2020/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/Concurso para Atribuição do Estatuto e Financiamento de Laboratórios Associados (LA)/LA%2FP%2F0140%2F2020/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/OE/2021.08629.BD/PT
oaire.fundingStream6817 - DCRRNI ID
oaire.fundingStreamConcurso para Atribuição do Estatuto e Financiamento de Laboratórios Associados (LA)
oaire.fundingStreamOE
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
rcaap.rightsopenAccess
relation.isProjectOfPublicatione07cf232-4705-4b5b-b2c4-af8f25311076
relation.isProjectOfPublicationecd6da06-821d-4fff-933b-319b334dc19a
relation.isProjectOfPublication41993e2b-d970-4169-8fb4-2819a3c988b6
relation.isProjectOfPublication.latestForDiscovery41993e2b-d970-4169-8fb4-2819a3c988b6

Ficheiros

Principais
A mostrar 1 - 1 de 1
Miniatura
Nome:
d4dt01490a.pdf
Tamanho:
4.64 MB
Formato:
Adobe Portable Document Format
Ver/Abrir

Coleções

Home collection (FCT)