Publicação
The role of Fbxo42 in Ataxin-2-mediated regulation of Xbp1 signalling
| datacite.subject.fos | Ciências Naturais | pt_PT |
| dc.contributor.advisor | Domingos, Pedro | |
| dc.contributor.author | Dias Santos, Cristiana Catarina | |
| dc.date.accessioned | 2025-07-31T14:20:45Z | |
| dc.date.embargo | 2026-04-30 | |
| dc.date.issued | 2025-07-07 | |
| dc.date.submitted | 2025-03-10 | |
| dc.description.abstract | "The accumulation of misfolded/unfolded proteins in the endoplasmic reticulum (ER) leads to a cellular condition known as “ER stress”. To alleviate this stress and restore cellular homeostasis, cells activate a signalling pathway collectively referred to as the Unfolded Protein Response (UPR). As a result, the ER sensor protein IRE1 is activated and mediates the splicing of XBP1 mRNA. Xbp1 spliced (Xbp1s) is an effective transcription factor and promotes the transcription of UPR-target genes, helping to reduce ER stress levels. However, when stress is prolonged or severe, it can lead to cell death by apoptosis.(...)" | pt_PT |
| dc.identifier.tid | 101827024 | |
| dc.identifier.uri | http://hdl.handle.net/10362/185811 | |
| dc.language.iso | eng | pt_PT |
| dc.relation | The role of the Fbox protein CG6758 in Endoplasmic Reticulum stress induced cell death | |
| dc.relation | Molecular, Structural and Cellular Microbiology – Instituto de Tecnologia Química e Biológica António Xavier | |
| dc.rights.uri | http://creativecommons.org/licenses/by/4.0/ | pt_PT |
| dc.subject | Fbxo42 gene | pt_PT |
| dc.subject | Rbx (SCF complexes) | pt_PT |
| dc.subject | HEK-293 cell | pt_PT |
| dc.subject | Ataxin-2 | pt_PT |
| dc.subject | Xbp1 mRNA | pt_PT |
| dc.title | The role of Fbxo42 in Ataxin-2-mediated regulation of Xbp1 signalling | pt_PT |
| dc.type | doctoral thesis | |
| dspace.entity.type | Publication | |
| oaire.awardNumber | SFRH/BD/130817/2017 | |
| oaire.awardNumber | UIDB/04612/2020 | |
| oaire.awardNumber | UIDP/04612/2020 | |
| oaire.awardTitle | The role of the Fbox protein CG6758 in Endoplasmic Reticulum stress induced cell death | |
| oaire.awardTitle | Molecular, Structural and Cellular Microbiology – Instituto de Tecnologia Química e Biológica António Xavier | |
| oaire.awardURI | info:eu-repo/grantAgreement/FCT//SFRH%2FBD%2F130817%2F2017/PT | |
| oaire.awardURI | info:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/UIDB%2F04612%2F2020/PT | |
| oaire.awardURI | info:eu-repo/grantAgreement/FCT/Concurso de avaliação no âmbito do Programa Plurianual de Financiamento de Unidades de I&D (2017%2F2018) - Financiamento Programático/UIDP%2F04612%2F2020/PT | |
| oaire.fundingStream | 6817 - DCRRNI ID | |
| oaire.fundingStream | Concurso de avaliação no âmbito do Programa Plurianual de Financiamento de Unidades de I&D (2017/2018) - Financiamento Programático | |
| project.funder.identifier | http://doi.org/10.13039/501100001871 | |
| project.funder.identifier | http://doi.org/10.13039/501100001871 | |
| project.funder.identifier | http://doi.org/10.13039/501100001871 | |
| project.funder.name | Fundação para a Ciência e a Tecnologia | |
| project.funder.name | Fundação para a Ciência e a Tecnologia | |
| project.funder.name | Fundação para a Ciência e a Tecnologia | |
| rcaap.embargofct | Artigos por publicar | pt_PT |
| rcaap.rights | embargoedAccess | pt_PT |
| rcaap.type | doctoralThesis | pt_PT |
| relation.isProjectOfPublication | 3cde4a2c-c857-47ae-ad8f-55e2278b0f03 | |
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| relation.isProjectOfPublication.latestForDiscovery | bf909003-8b76-4e06-97ed-16dd481e7f8c | |
| thesis.degree.name | Dissertation presented to obtain the Ph.D degree in Molecular Biosciences | pt_PT |