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Epidemiology and genetic diversity of invasive Neisseria meningitidis strains circulating in Portugal from 2003 to 2020

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dc.contributor.authorBettencourt, Célia
dc.contributor.authorNunes, Alexandra
dc.contributor.authorNogueira, Paulo
dc.contributor.authorDuarte, Sílvia
dc.contributor.authorSilva, Catarina
dc.contributor.authorGomes, João Paulo
dc.contributor.authorSimões, Maria João
dc.contributor.institutionEscola Nacional de Saúde Pública (ENSP)
dc.contributor.institutionComprehensive Health Research Centre (CHRC) - Pólo ENSP
dc.contributor.institutionCentro de Investigação em Saúde Pública (CISP/PHRC)
dc.contributor.pblViguera Editores, S.L.
dc.date.accessioned2023-12-20T23:56:29Z
dc.date.available2023-12-20T23:56:29Z
dc.date.issued2023
dc.descriptionPublisher Copyright: © 2023, The Author(s).
dc.description.abstractInvasive meningococcal disease (IMD) continues to be a public health problem due to its epidemic potential, affecting mostly children. We aimed to present a detailed description of the epidemiology of IMD in Portugal, including insights into the genetic diversity of Neisseria meningitidis strains. Epidemiological analysis included data from the Portuguese National Reference Laboratory of Neisseria meningitidis during 2003 to 2020. Since 2012, N. meningitidis isolates have also been assessed for their susceptibility to antibiotics and were characterized by whole genome sequencing. During 2003–2020, 1392 confirmed cases of IMD were analyzed. A decrease in the annual incidence rate was observed, ranging from 1.99 (2003) to 0.39 (2020), with an average case fatality rate of 7.1%. Serogroup B was the most frequent (69.7%), followed by serogroups C (9.7%), Y (5.7%), and W (2.6%). Genomic characterization of 329 isolates identified 20 clonal complexes (cc), with the most prevalent belonging to serogroup B cc41/44 (26.3%) and cc213 (16.3%). Isolates belonging to cc11 were predominantly from serogroups W (77.3%) and C (76.5%), whereas cc23 was dominant from serogroup Y (65.7%). Over the past 4 years (2017–2020), we observed an increasing trend of cases assigned to cc213, cc32, and cc11. Regarding antimicrobial susceptibility, all isolates were susceptible to ceftriaxone and 61.8% were penicillin-nonsusceptible, whereas 1.4% and 1.0% were resistant to ciprofloxacin and rifampicin. This is the first detailed study on the epidemiology and genomics of invasive N. meningitidis infections in Portugal, providing relevant data to public health policy makers for a more effective control of this disease.en
dc.description.versionpublishersversion
dc.description.versioninpress
dc.format.extent1424674
dc.identifier.doi10.1007/s10123-023-00463-w
dc.identifier.issn1139-6709
dc.identifier.otherPURE: 78797917
dc.identifier.otherPURE UUID: 214ab8e5-95d7-47a3-994c-1f3c2e65c014
dc.identifier.otherScopus: 85178966457
dc.identifier.otherPubMed: 38057459
dc.identifier.otherWOS: 001196149800001
dc.identifier.urihttp://hdl.handle.net/10362/161529
dc.identifier.urlhttps://www.scopus.com/pages/publications/85178966457
dc.language.isoeng
dc.peerreviewedyes
dc.subjectEpidemiology
dc.subjectNeisseria meningitidis
dc.subjectPortugal
dc.subjectSurveillance
dc.subjectWhole genome sequencing
dc.subjectMicrobiology
dc.subjectMicrobiology (medical)
dc.subjectSDG 3 - Good Health and Well-being
dc.titleEpidemiology and genetic diversity of invasive Neisseria meningitidis strains circulating in Portugal from 2003 to 2020en
dc.typejournal article
degois.publication.titleInternational Microbiology
dspace.entity.typePublication
rcaap.rightsopenAccess

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