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Statins as an Adjunctive Antithrombotic Agent in Thrombotic Antiphospholipid Syndrome

2025-03Recensão Acesso aberto
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dc.contributor.authorBucci, Tommaso
dc.contributor.authorBucci, Tommaso
dc.contributor.authorMenichelli, Danilo
dc.contributor.authorMenichelli, Danilo
dc.contributor.authorPalumbo, Ilaria Maria
dc.contributor.authorPastori, Daniele
dc.contributor.authorPastori, Daniele
dc.contributor.authorAmes, Paul R.J.
dc.contributor.authorLip, Gregory Y.H.
dc.contributor.authorLip, Gregory
dc.contributor.authorPignatelli, Pasquale
dc.contributor.authorPignatelli, Pasquale
dc.contributor.institutioniNOVA4Health - pólo NMS
dc.contributor.institutionNOVA Medical School|Faculdade de Ciências Médicas (NMS|FCM)
dc.contributor.pblMDPI - Multidisciplinary Digital Publishing Institute
dc.date.accessioned2025-04-10T15:58:42Z
dc.date.available2025-04-10T15:58:42Z
dc.date.issued2025-03
dc.descriptionPublisher Copyright: © 2025 by the authors.
dc.description.abstractThe thrombotic physiopathology of antiphospholipid syndrome (APS) is complex, heterogeneous, and dynamic. While venous thromboembolism (VTE) is the most common initial presentation, arterial thrombotic events (ATE) become more frequent in advanced stages and are associated with high morbidity and mortality. Despite the use of oral anticoagulants (OACs), thrombotic APS remains associated with a high risk of recurrent thrombosis. Given their potential antithrombotic effects capable of reducing the risk of both VTE and ATE, statins have been proposed as an adjunctive therapy to OACs for patients with APS and recurrent thrombosis. However, this recommendation is primarily based on studies not specifically conducted in APS populations, with only preclinical data or evidence from retrospective observational studies available from APS patients cohorts. For these reasons, this narrative review aims to synthesise the studies evaluating the potential antithrombotic effects of statins in patients with APS, highlighting the progress made and identifying areas for future research.en
dc.description.versionpublishersversion
dc.description.versionpublished
dc.format.extent1461638
dc.identifier.doi10.3390/cells14050353
dc.identifier.issn2073-4409
dc.identifier.otherPURE: 114066969
dc.identifier.otherPURE UUID: be2960e4-efa2-44aa-b994-9edab6d49b29
dc.identifier.otherScopus: 105000041392
dc.identifier.otherPubMed: 40072082
dc.identifier.urihttp://hdl.handle.net/10362/182052
dc.identifier.urlhttps://www.scopus.com/pages/publications/105000041392
dc.language.isoeng
dc.peerreviewedyes
dc.subjectantiphospholipid syndrome
dc.subjectmechanism
dc.subjectstatins
dc.subjectthrombosis
dc.subjectGeneral Biochemistry,Genetics and Molecular Biology
dc.titleStatins as an Adjunctive Antithrombotic Agent in Thrombotic Antiphospholipid Syndromeen
dc.title.subtitleMechanisms and Clinical Implicationsen
dc.typereview
degois.publication.issue5
degois.publication.titleCells
degois.publication.volume14
dspace.entity.typePublication
person.familyNameBucci
person.familyNameMenichelli
person.familyNamepastori
person.familyNameLip
person.familyNamepignatelli
person.givenNameTommaso
person.givenNameDanilo
person.givenNamedaniele
person.givenNameGregory
person.givenNamepasquale
person.identifier1960682
person.identifier689431
person.identifier689430
person.identifier182829
person.identifier.orcid0000-0003-2895-6234
person.identifier.orcid0000-0001-9467-5903
person.identifier.orcid0000-0001-6357-5213
person.identifier.orcid0000-0002-7566-1626
person.identifier.orcid0000-0002-2265-7455
person.identifier.ridABA-4162-2021
person.identifier.ridW-5498-2018
person.identifier.ridJ-7087-2016
person.identifier.ridK-2116-2016
person.identifier.scopus-author-id56367803800
person.identifier.scopus-author-id57191358602
person.identifier.scopus-author-id35741492700
person.identifier.scopus-author-id7003808847
rcaap.rightsopenAccess
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relation.isAuthorOfPublication.latestForDiscoverycc9a84ad-fe70-4722-8972-ae16df1e826b

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