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Extremely preterm neonates have more Lactobacillus in meconium than very preterm neonates–the in utero microbial colonization hypothesis

2020-11Artigo científico Acesso aberto
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dc.contributor.authorMorais, Juliana
dc.contributor.authorMarques, Cláudia
dc.contributor.authorTeixeira, Diana
dc.contributor.authorDurão, Catarina
dc.contributor.authorFaria, Ana
dc.contributor.authorBrito, Sara
dc.contributor.authorCardoso, Manuela
dc.contributor.authorMacedo, Israel
dc.contributor.authorPereira, Esmeralda
dc.contributor.authorTomé, Teresa
dc.contributor.authorCalhau, Conceição
dc.contributor.authorCalhau, Conceição
dc.contributor.institutionNOVA Medical School|Faculdade de Ciências Médicas (NMS|FCM)
dc.contributor.institutionComprehensive Health Research Centre (CHRC) - pólo NMS
dc.contributor.pblTaylor & Francis
dc.date.accessioned2020-10-19T23:24:45Z
dc.date.available2020-10-19T23:24:45Z
dc.date.issued2020-11
dc.descriptionThis study was supported by Milupa DN-ELN 2017 grant from the Portuguese Neonatal Society, by ERDF through the operation POCI-01-0145-ERDF-007746 funded by the Programa Operacional Competitividade e Internacionalização – COMPETE2020 and by National Funds through FCT – Fundação para a Ciência e a Tecnologia within CINTESIS,R&D Unit (reference UID/IC/4255/2013).
dc.description.abstractGrowing evidence suggests that maternal microbiota can influence the neonates’ gut colonization. However, the mechanisms of vertical bacterial transmission remain poorly defined. We believed that the first colonizers of the newborn come from the mother’s gut and vagina during pregnancy and that this is independent of the mode of delivery. We conducted an observational longitudinal study to evaluate the link between the maternal gut microbiota and the meconium’s microbiota in extremely and very preterm neonates. Bacterial DNA was extracted from samples and specific bacterial groups were quantified by RT-PCR. In this cohort of 117 preterm neonates, we detected bacterial DNA in 88% of meconium samples. Meconium microbiota of neonates born after 28 gestational weeks (very preterm neonates) showed stronger correlations with their mothers’ fecal microbiota. However, neonates born before 28 gestational weeks (extremely preterm neonates) had more Lactobacillus–genus that dominated the vaginal microbiota–than very preterm neonates, regardless of the mode of delivery. Collectively, these data support the hypothesis that maternal bacteria from the gut and vagina can play a role in shaping neonates’ gut microbiota and that mother-to-infant bacterial transmission is a controlled and time-specific process. ClinicalTrials.gov Identifier: NCT03663556.en
dc.description.versionpublishersversion
dc.description.versionpublished
dc.format.extent9
dc.format.extent3569683
dc.identifier.doi10.1080/19490976.2020.1785804
dc.identifier.issn1949-0976
dc.identifier.otherPURE: 19218950
dc.identifier.otherPURE UUID: 627c34cd-43b3-476d-92c5-121e75ed5216
dc.identifier.otherScopus: 85087913757
dc.identifier.otherPubMed: 32658601
dc.identifier.otherWOS: 000552787400001
dc.identifier.urihttp://hdl.handle.net/10362/105897
dc.identifier.urlhttps://www.scopus.com/pages/publications/85087913757
dc.language.isoeng
dc.peerreviewedyes
dc.subjectLactobacillus
dc.subjectmaternal microbiota
dc.subjectmeconium
dc.subjectpreterm neonates
dc.subjectMicrobiology
dc.subjectGastroenterology
dc.subjectMicrobiology (medical)
dc.subjectInfectious Diseases
dc.subjectSDG 3 - Good Health and Well-being
dc.titleExtremely preterm neonates have more Lactobacillus in meconium than very preterm neonates–the in utero microbial colonization hypothesisen
dc.typejournal article
degois.publication.issue1
degois.publication.titleGut Microbes
degois.publication.volume12
dspace.entity.typePublication
person.familyNameCalhau
person.givenNameConceição
person.identifier.ciencia-id2110-0420-1717
person.identifier.orcid0000-0001-9567-3379
person.identifier.scopus-author-id6701578877
rcaap.rightsopenAccess
relation.isAuthorOfPublication32b016c8-810a-40be-b9ee-ddfb07668a78
relation.isAuthorOfPublication.latestForDiscovery32b016c8-810a-40be-b9ee-ddfb07668a78

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