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Publicação
Auditory Subcortical Circuitry in Rodents
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Resumo(s)
"The role of subcortical structures in binaural integration is of significant interest in
auditory neuroscience, as these structures are pivotal for processing and
interpreting spatial auditory cues. The inferior colliculus (IC), as the primary auditory
midbrain center, serves as a critical hub where ascending and descending auditory
projections converge. It has been suggested that the IC encodes auditory
information through a push-pull mechanism mediated by interactions between the
two ICs. However, the origins of this push-pull mechanism within the brain, as well
as its interactions with upstream and downstream subcortical areas, remain topics
of substantial debate. In this study, we utilize functional MRI (fMRI) in combination
with IC lesions in the rat model to investigate the push-pull interaction from a
pathway-wide perspective, shedding light on its role in subcortical auditory
processing. We provide evidence supporting the existence of the push-pull
mechanism in the IC, demonstrated by the presence of negative and positive fMRI
signals in the ipsilateral and contralateral ICs, respectively, in response to monaural
stimulation. By unilaterally lesioning the contralateral IC, we establish the necessity
of both collicular integrity and intercollicular interactions for the proper functioning of
the push-pull mechanism.(...)"
Descrição
Palavras-chave
Auditory processing sound localization inferior colliculus chemical exchange saturation transfer (CEST) magnetic resonance imaging neuroplasticity push-pull mechanism functional MRI