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Fecal microbiota transplantation—could stool donors’ and receptors’ diet be the key to future success?

2023-11Artigo científico Acesso aberto
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dc.contributor.authorSilva, Rita
dc.contributor.authorDinis, Liliana
dc.contributor.authorPeris, Arnau
dc.contributor.authorNovais, Luís
dc.contributor.authorCalhau, Conceição
dc.contributor.authorCalhau, Conceição
dc.contributor.authorPestana, Diogo
dc.contributor.authorMarques, Cláudia
dc.contributor.institutionNOVA Medical School|Faculdade de Ciências Médicas (NMS|FCM)
dc.contributor.institutionCentro de Investigação em Tecnologias e Serviços de Saúde (CINTESIS)
dc.contributor.institutionComprehensive Health Research Centre (CHRC) - pólo NMS
dc.contributor.pblFrontiers Media
dc.date.accessioned2024-09-30T22:33:10Z
dc.date.available2024-09-30T22:33:10Z
dc.date.issued2023-11
dc.descriptionPublisher Copyright: Copyright © 2023 Silva, Dinis, Peris, Novais, Calhau, Pestana and Marques.
dc.description.abstractFecal microbiota transplantation (FMT) is indicated in many countries for patients with multiple recurrences of Clostridioides difficile infection (CDI) for whom appropriate antibiotic treatments have failed. Donor selection is a demanding and rigorous process in view of the implementation of FMT programs worldwide. One of the most noteworthy factors that has been shown to affect FMT outcomes is the microbial diversity of the stool donor. A detailed assessment of the donor’s microbiota is crucial, as the microbiota is complex, dynamic, and resilient, and a healthy microbiota has several dimensions in addition to the absence of pathogens. Diet is one of the most important factors that modulates the composition and function of the gut microbiome (GM) and has a critical role in orchestrating the host–microbiota crosstalk throughout life. The diversity of the human GM seems to be related to variations in dietary patterns. Currently, the dietary patterns of stool donors and receptors are not taken into consideration in any way for FMT. In this study, we reflect on the importance of including this type of assessment in the stool donor screening process and knowing the impact of diet on the GM, as well as the importance of monitoring receptors’ diet to ensure the engraftment of the transplanted microbiota.en
dc.description.versionpublishersversion
dc.description.versionpublished
dc.format.extent754469
dc.identifier.doi10.3389/fgstr.2023.1270899
dc.identifier.issn2813-1169
dc.identifier.otherPURE: 100251059
dc.identifier.otherPURE UUID: 91d7054e-eb6f-4146-9d70-ebb7bd71a80e
dc.identifier.otherScopus: 85204693476
dc.identifier.urihttp://hdl.handle.net/10362/172752
dc.identifier.urlhttps://www.scopus.com/pages/publications/85204693476
dc.language.isoeng
dc.peerreviewedyes
dc.subjectdiet
dc.subjectfecal microbiota transplantation
dc.subjectFMT receptors
dc.subjectgut microbiota
dc.subjectstool donors
dc.subjectGastroenterology
dc.subjectHepatology
dc.subjectSDG 3 - Good Health and Well-being
dc.titleFecal microbiota transplantation—could stool donors’ and receptors’ diet be the key to future success?en
dc.typejournal article
degois.publication.titleFrontiers in Gastroenterology
degois.publication.volume2
dspace.entity.typePublication
person.familyNameCalhau
person.givenNameConceição
person.identifier.ciencia-id2110-0420-1717
person.identifier.orcid0000-0001-9567-3379
person.identifier.scopus-author-id6701578877
rcaap.rightsopenAccess
relation.isAuthorOfPublication32b016c8-810a-40be-b9ee-ddfb07668a78
relation.isAuthorOfPublication.latestForDiscovery32b016c8-810a-40be-b9ee-ddfb07668a78

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