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Vaccination Recommendations for the Immunocompromised Adult Patient

2025-12-03Artigo científico Acesso aberto
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dc.contributor.authorAbreu, Cândida
dc.contributor.authorPeres, Susana
dc.contributor.authorCunha, Flávia
dc.contributor.authorMiranda, Joana
dc.contributor.authorNunes-Silva, Cláudio
dc.contributor.authorSilva-Pinto, André
dc.contributor.authorRibeiro-Dias, Lúcia
dc.contributor.authorOliveira, Joaquim
dc.contributor.institutionNOVA Medical School|Faculdade de Ciências Médicas (NMS|FCM)
dc.contributor.pblBiblioteca Nacional de Portugal, Centro de Estudos Históricos, CELOM
dc.date.accessioned2026-01-14T15:52:01Z
dc.date.available2026-01-14T15:52:01Z
dc.date.issued2025-12-03
dc.descriptionPublisher Copyright: Copyright © Ordem dos Médicos 2025.
dc.description.abstractThe manuscript collates indications for vaccination in immunocompromised adults based on recommendations from leading international institutions. These individuals have increased vulnerability to vaccine-preventable infectious diseases, and their immune response to vaccination is often weaker than that of immunocompetent individuals. Therefore, whenever possible, it is important to assess vaccine response (serological or other). Emphasis is placed on adapting vaccination to the net state of immunosuppression, following a careful evaluation of risks, indications, contraindications, and the optimal timing for administration. Whenever feasible, vaccination should be carried out before the initiation of pharmacological immunosuppression, prior to splenectomy, or before receiving a solid organ transplant. Immunocompromised individuals are categorised into groups such as those with immune-mediated inflammatory diseases, individuals who have undergone splenectomy, recipients of solid organ or haematopoietic transplants, people living with HIV, and those with congenital immunodeficiencies (inborn errors). The article describes vaccination recommendations for different clinical scenarios and types of immunosuppression. Vaccines against respiratory viral diseases, including influenza, COVID-19, and respiratory syncytial virus, as well as hepatitis A and B, varicella-zoster, and vaccines protecting against encapsulated bacteria such as pneumococci, meningococci, and Haemophilus influenzae, are discussed. Some vaccination recommendations in the context of travel and post-exposure prophylaxis in high-risk situations are included. The article also addresses the importance of vaccinating household contacts and healthcare professionals for additional protection. Finally, it highlights that ongoing advancements in vaccines and vaccination guidelines require continuous updates.en
dc.description.versionpublishersversion
dc.description.versionpublished
dc.format.extent14
dc.format.extent786048
dc.identifier.doi10.20344/amp.22966
dc.identifier.issn0870-399X
dc.identifier.otherPURE: 147353387
dc.identifier.otherPURE UUID: 14c39e27-e4fb-4403-948f-2228df3fecca
dc.identifier.otherScopus: 105023854100
dc.identifier.otherPubMed: 41353643
dc.identifier.urihttp://hdl.handle.net/10362/198999
dc.identifier.urlhttps://www.scopus.com/pages/publications/105023854100
dc.language.isoeng
dc.peerreviewedyes
dc.subjectImmunocompromised Host
dc.subjectTransplant Recipients
dc.subjectVaccination
dc.subjectVaccines
dc.subjectGeneral Medicine
dc.subjectSDG 3 - Good Health and Well-being
dc.titleVaccination Recommendations for the Immunocompromised Adult Patienten
dc.typejournal article
degois.publication.firstPage814
degois.publication.issue12
degois.publication.lastPage827
degois.publication.titleActa Medica Portuguesa
degois.publication.volume38
dspace.entity.typePublication
rcaap.rightsopenAccess

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