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Electrospun membranes from natural polymers with Quercetin

2025-10-15Artigo científico Acesso aberto
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dc.contributor.authorCorreia, Catarina
dc.contributor.authorPádua, Ana Sofia
dc.contributor.authorMatela, Catarina
dc.contributor.authorGonçalves, Inês C.
dc.contributor.authorSoares, Paula
dc.contributor.authorHenriques, Célia
dc.contributor.authorSá-Nogueira, Isabel
dc.contributor.authorSilva, Jorge Carvalho
dc.contributor.authorVieira, Tânia
dc.contributor.institutionDCV - Departamento de Ciências da Vida
dc.contributor.institutionDCM - Departamento de Ciência dos Materiais
dc.contributor.institutionDF – Departamento de Física
dc.contributor.pblElsevier
dc.date.accessioned2025-09-01T22:10:29Z
dc.date.available2025-09-01T22:10:29Z
dc.date.issued2025-10-15
dc.descriptionFunding Information: This research was funded by the FCT – Fundação para a Ciência e a Tecnologia, I.P., in the scope of the projects 2022.07258.PTDC (123SkinHeal) and the projects LA/P/0037/2020, UIDP/50025/2020 and UIDB/50025/2020 of the Associate Laboratory Institute of Nanostructures, Nanomodelling and Nanofabrication-i3N. It was also funded by FCT – Fundação para a Ciência e a Tecnologia, I.P., in the scope of the project UIDP/04378/2020 and UIDB/04378/2020 of the Research Unit on Applied Molecular Biosciences - and the project LA/P/0140/2020 of the Associate Laboratory Institute for Health and Bioeconomy - i4HB. Publisher Copyright: © 2025 The Author(s)
dc.description.abstractThe rising problem of chronic wounds demands the investigation of therapeutic solutions that are easy to use, target microbial infection and excessive reactive oxygen species (ROS) at the wound site, and account for skin reinnervation. The aim of this research was to develop electrospun membranes from natural polymers – chitosan (CS) and fish gelatin (FG) − crosslinked with citric acid, incorporating quercetin as an active pharmaceutical ingredient (API) to enhance its therapeutic potential. The produced membranes exhibited a uniform morphology and a cross-shaped network, providing porosity and the ability to sustain hydrolytic degradation. Drug delivery assays revealed a higher release percentage at pH 7.4 and pH 8, which correspond to wound site conditions. However, quercetin degradation at this pH suggests the need for encapsulation. Antioxidant activity analysis confirmed quercetin's great antioxidant capabilities, reaching up to 93.71 ± 0.92 % for pure quercetin, and 53.77 ± 3.09 % for quercetin-containing fibers. Neuronal differentiation assays demonstrated quercetin's ability to promote neuronal differentiation. Antibacterial activity was tested for the membranes against Escherichia coli (E. coli) and Methycillin-resistant staphylococcus aureus (MRSA). The results showed a beneficial effect from incorporating quercetin into the membranes in reducing MRSA growth but no noticeable effects on E. coli. These findings highlight the potential of quercetin-loaded fibers for wound healing applications, with antioxidant, antibacterial, and neurogenic properties.en
dc.description.versionpublishersversion
dc.description.versionpublished
dc.format.extent12
dc.format.extent6547522
dc.identifier.doi10.1016/j.ijpharm.2025.126062
dc.identifier.issn0378-5173
dc.identifier.otherPURE: 128443619
dc.identifier.otherPURE UUID: 10d24c51-4ff0-4628-9b6b-a70684e29327
dc.identifier.otherScopus: 105013485429
dc.identifier.otherPubMed: 40803422
dc.identifier.otherORCID: /0000-0001-9959-4272/work/190961863
dc.identifier.otherORCID: /0000-0003-2711-1184/work/190962266
dc.identifier.otherORCID: /0000-0001-8447-1886/work/190962763
dc.identifier.urihttp://hdl.handle.net/10362/187359
dc.identifier.urlhttps://www.scopus.com/pages/publications/105013485429
dc.language.isoeng
dc.peerreviewedyes
dc.relationinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/LA%2FP%2F0037%2F2020/PT
dc.relationInstitute of Nanostructures, Nanomodelling and Nanofabrication
dc.relationInstitute of Nanostructures, Nanomodelling and Nanofabrication
dc.relationinfo:eu-repo/grantAgreement/FCT/Concurso de avaliação no âmbito do Programa Plurianual de Financiamento de Unidades de I&D (2017%2F2018) - Financiamento Base/UIDB%2F50025%2F2020/PT
dc.relationApplied Molecular Biosciences Unit
dc.relationApplied Molecular Biosciences Unit
dc.relationinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/UIDB%2F04378%2F2020/PT
dc.relationinfo:eu-repo/grantAgreement/FCT/Concurso para Atribuição do Estatuto e Financiamento de Laboratórios Associados (LA)/LA%2FP%2F0140%2F2020/PT
dc.subjectAntimicrobial
dc.subjectAntioxidant
dc.subjectElectrospinning
dc.subjectNeuronal differentiation
dc.subjectQuercetin
dc.subjectWound healing
dc.subjectPharmaceutical Science
dc.titleElectrospun membranes from natural polymers with Quercetinen
dc.title.subtitledesign and characterization, antioxidant and antimicrobial activity, and potential for skin reinnervation in chronic woundsen
dc.typejournal article
degois.publication.firstPage1
degois.publication.lastPage12
degois.publication.titleInternational Journal of Pharmaceutics
degois.publication.volume683
dspace.entity.typePublication
oaire.awardNumberLA/P/0037/2020
oaire.awardNumberUIDP/50025/2020
oaire.awardNumberUIDB/50025/2020
oaire.awardNumberUIDP/04378/2020
oaire.awardNumberUIDB/04378/2020
oaire.awardNumberLA/P/0140/2020
oaire.awardTitleInstitute of Nanostructures, Nanomodelling and Nanofabrication
oaire.awardTitleInstitute of Nanostructures, Nanomodelling and Nanofabrication
oaire.awardTitleApplied Molecular Biosciences Unit
oaire.awardTitleApplied Molecular Biosciences Unit
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/LA%2FP%2F0037%2F2020/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/UIDP%2F50025%2F2020/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/Concurso de avaliação no âmbito do Programa Plurianual de Financiamento de Unidades de I&D (2017%2F2018) - Financiamento Base/UIDB%2F50025%2F2020/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/UIDP%2F04378%2F2020/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/UIDB%2F04378%2F2020/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/Concurso para Atribuição do Estatuto e Financiamento de Laboratórios Associados (LA)/LA%2FP%2F0140%2F2020/PT
oaire.fundingStream6817 - DCRRNI ID
oaire.fundingStream6817 - DCRRNI ID
oaire.fundingStreamConcurso de avaliação no âmbito do Programa Plurianual de Financiamento de Unidades de I&D (2017/2018) - Financiamento Base
oaire.fundingStream6817 - DCRRNI ID
oaire.fundingStream6817 - DCRRNI ID
oaire.fundingStreamConcurso para Atribuição do Estatuto e Financiamento de Laboratórios Associados (LA)
project.funder.identifierhttp://doi.org/10.13039/501100001871
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rcaap.rightsopenAccess
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