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Pro-Inflammatory Priming of the Brain

2023-05Artigo científico Acesso aberto
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dc.contributor.authorMartins, Ana Catarina
dc.contributor.authorLima, Illyane Sofia
dc.contributor.authorPêgo, Ana Catarina
dc.contributor.authorSá Pereira, Inês
dc.contributor.authorMartins, Gracelino
dc.contributor.authorKapitão, Antonino
dc.contributor.authorGozzelino, Raffaella
dc.contributor.institutionNOVA Medical School|Faculdade de Ciências Médicas (NMS|FCM)
dc.contributor.pblMDPI - Multidisciplinary Digital Publishing Institute
dc.date.accessioned2023-05-25T22:19:48Z
dc.date.available2023-05-25T22:19:48Z
dc.date.issued2023-05
dc.descriptionFunding Information: This research was funded by FWO and F.R.S.-FNRS under the Excellence of Science Program (EOS), MODEL-IDI Ref. number 30826052 and CD-INFLADIS Ref. number 40007512. A.C.P. is funded by FCT SFRH/BD/14611/2019. I.S.L was funded by FCT SFRH/BD/114552/2016 and is funded by MODEL-IDI Ref. number 30826052; A.C.M was funded by FCT SFRH/BD/104599/2014; R.G. was funded by FCT IF 01495/2016. Publisher Copyright: © 2023 by the authors.
dc.description.abstractParkinson’s disease (PD) is a multifactorial neurodegenerative pathology characterized by the progressive loss of dopaminergic neurons in the substantia nigra of the brain. Aging is considered the main risk factor for the development of idiopathic PD. However, immunity and inflammation play a crucial role in the pathogenesis of this disorder. In mice, we showed that pro-inflammatory priming of the brain sensitizes to severe PD development, regardless of animal age. Age-related sub-acute inflammation, as well as the activation of the immune response upon exposure to harmful stimuli, enhances PD manifestations. The severity of PD is influenced by the engagement of host resistance mechanisms against infection based on the removal of iron (Fe) from the circulation. The sequestration of Fe by immune cells prevents pathogens from proliferating. However, it leads to the formation of a Fe-loaded circulating compartment. When entering the brain through a compromised blood-brain barrier, Fe-loaded immune cells contribute to enhancing neuroinflammation and brain Fe overload. Thus, pro-inflammatory priming of the brain exacerbates neuronal damage and represents a risk factor for the development of severe PD symptoms. Further investigations are now required to better understand whether therapeutic interventions inhibiting this phenomenon might protect against PD.en
dc.description.versionpublishersversion
dc.description.versionpublished
dc.format.extent3270492
dc.identifier.doi10.3390/ijms24097949
dc.identifier.issn1661-6596
dc.identifier.otherPURE: 61536768
dc.identifier.otherPURE UUID: 575dfe78-d400-4870-bf0f-f046d67aee73
dc.identifier.otherScopus: 85159309935
dc.identifier.otherPubMed: 37175654
dc.identifier.otherWOS: 000987583300001
dc.identifier.urihttp://hdl.handle.net/10362/153174
dc.identifier.urlhttps://www.scopus.com/pages/publications/85159309935
dc.language.isoeng
dc.peerreviewedyes
dc.subjectimmunity
dc.subjectinfection
dc.subjectiron metabolism
dc.subjectneuroinflammation
dc.subjectParkinson’s disease
dc.subjectCatalysis
dc.subjectMolecular Biology
dc.subjectSpectroscopy
dc.subjectComputer Science Applications
dc.subjectPhysical and Theoretical Chemistry
dc.subjectOrganic Chemistry
dc.subjectInorganic Chemistry
dc.titlePro-Inflammatory Priming of the Brainen
dc.title.subtitleThe Underlying Cause of Parkinson’s Diseaseen
dc.typejournal article
degois.publication.issue9
degois.publication.titleInternational Journal of Molecular Sciences
degois.publication.volume24
dspace.entity.typePublication
rcaap.rightsopenAccess

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