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Monocytes as Endothelial Progenitor Cells (EPCs), Another Brick in the Wall to Disentangle Tumor Angiogenesis

2020-01-01Artigo científico Acesso aberto
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dc.contributor.authorLopes-Coelho, Filipa
dc.contributor.authorSilva, Fernanda
dc.contributor.authorGouveia-Fernandes, Sofia
dc.contributor.authorMartins, Carmo
dc.contributor.authorLopes, Nuno
dc.contributor.authorDomingues, Germana
dc.contributor.authorBrito, Catarina
dc.contributor.authorAlmeida, António M
dc.contributor.authorPereira, Sofia A
dc.contributor.authorSA, Pereira
dc.contributor.authorSerpa, Jacinta
dc.contributor.authorSerpa, Jacinta
dc.contributor.institutionCentro de Estudos de Doenças Crónicas (CEDOC)
dc.contributor.institutionNOVA Medical School|Faculdade de Ciências Médicas (NMS|FCM)
dc.contributor.institutionInstituto de Tecnologia Química e Biológica António Xavier (ITQB)
dc.contributor.pblMDPI - Multidisciplinary Digital Publishing Institute
dc.date.accessioned2020-04-22T22:34:23Z
dc.date.available2020-04-22T22:34:23Z
dc.date.issued2020-01-01
dc.descriptionThe project was funded by IPOLFG, EPE, by iNOVA4Health (UID/Multi/04462/2019) a program financially supported by Fundação para a Ciência e Tecnologia/Ministério da Educação e Ciência, through national funds and co-funded by FEDER under the PT2020 Partnership Agreement and by Fundação para a Ciência eTecnologia (PhD student fellowship: PD/BD/128337/2017).
dc.description.abstractBone marrow contains endothelial progenitor cells (EPCs) that, upon pro-angiogenic stimuli, migrate and differentiate into endothelial cells (ECs) and contribute to re-endothelialization and neo-vascularization. There are currently no reliable markers to characterize EPCs, leading to their inaccurate identification. In the past, we showed that, in a panel of tumors, some cells on the vessel wall co-expressed CD14 (monocytic marker) and CD31 (EC marker), indicating a putative differentiation route of monocytes into ECs. Herein, we disclosed monocytes as potential EPCs, using in vitro and in vivo models, and also addressed the cancer context. Monocytes acquired the capacity to express ECs markers and were able to be incorporated into blood vessels, contributing to cancer progression, by being incorporated in tumor neo-vasculature. Reactive oxygen species (ROS) push monocytes to EC differentiation, and this phenotype is reverted by cysteine (a scavenger and precursor of glutathione), which indicates that angiogenesis is controlled by the interplay between the oxidative stress and the scavenging capacity of the tumor microenvironment.en
dc.description.versionpublishersversion
dc.description.versionpublished
dc.format.extent9704601
dc.identifier.doi10.3390/cells9010107
dc.identifier.issn2073-4409
dc.identifier.otherPURE: 16703875
dc.identifier.otherPURE UUID: 084d64e2-a2a5-4e14-ab7e-22d9cf6a91e0
dc.identifier.otherPubMed: 31906296
dc.identifier.otherWOS: 000515398200107
dc.identifier.otherORCID: /0000-0002-8456-9995/work/72856281
dc.identifier.otherORCID: /0000-0002-1548-5907/work/72856826
dc.identifier.otherScopus: 85088045365
dc.identifier.urihttp://hdl.handle.net/10362/96647
dc.language.isoeng
dc.peerreviewedyes
dc.subjectangiogenesis
dc.subjectcancer
dc.subjectendothelial cells (ECs)
dc.subjectendothelial progenitor cells (EPCs)
dc.subjectmonocytes
dc.subjectSDG 3 - Good Health and Well-being
dc.titleMonocytes as Endothelial Progenitor Cells (EPCs), Another Brick in the Wall to Disentangle Tumor Angiogenesisen
dc.typejournal article
degois.publication.issue1
degois.publication.titleCells
degois.publication.volume9
dspace.entity.typePublication
person.familyNamede Azeredo Pereira
person.familyNameSerpa
person.givenNameSofia
person.givenNameJacinta
person.identifier562223
person.identifier.ciencia-id6B13-7601-73A2
person.identifier.ciencia-id2610-7C0D-38F2
person.identifier.orcid0000-0002-8456-9995
person.identifier.orcid0000-0002-1548-5907
person.identifier.ridM-2976-2019
person.identifier.ridO-8942-2014
person.identifier.scopus-author-id35190948700
person.identifier.scopus-author-id6601922586
rcaap.rightsopenAccess
relation.isAuthorOfPublicationf4809377-832b-40b5-92ca-0bb1c6fe14f3
relation.isAuthorOfPublication5f6eaca2-f01f-4894-8da2-688671913214
relation.isAuthorOfPublication.latestForDiscoveryf4809377-832b-40b5-92ca-0bb1c6fe14f3

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