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Predicting Cellular Rejection of Renal Allograft Based on the Serum Proteomic Fingerprint

2024-04Artigo científico Acesso aberto
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dc.contributor.authorRamalhete, Luís
dc.contributor.authorRamalhete, Luís
dc.contributor.authorVieira, Miguel Bigotte
dc.contributor.authorVieira, Miguel Bigotte
dc.contributor.authorAraújo, Rúben
dc.contributor.authorAraújo, Rúben
dc.contributor.authorVigia, Emanuel
dc.contributor.authorVigia, Emanuel
dc.contributor.authorAires, Inês
dc.contributor.authorFerreira, Aníbal
dc.contributor.authorFerreira, Anibal
dc.contributor.authorCalado, Cecília R.C.
dc.contributor.authorCalado, Cecília
dc.contributor.institutionNOVA Medical School|Faculdade de Ciências Médicas (NMS|FCM)
dc.contributor.institutioniNOVA4Health - pólo NMS
dc.contributor.pblMDPI - Multidisciplinary Digital Publishing Institute
dc.date.accessioned2024-04-24T00:48:00Z
dc.date.available2024-04-24T00:48:00Z
dc.date.issued2024-04
dc.descriptionPublisher Copyright: © 2024 by the authors.
dc.description.abstractKidney transplantation is an essential medical procedure that significantly enhances the survival rates and quality of life for patients with end-stage kidney disease. However, despite advancements in immunosuppressive therapies, allograft rejection remains a leading cause of organ loss. Notably, predictions of cellular rejection processes primarily rely on biopsy analysis, which is not routinely performed due to its invasive nature. The present work evaluates if the serum proteomic fingerprint, as acquired by Fourier Transform Infrared (FTIR) spectroscopy, can predict cellular rejection processes. We analyzed 28 serum samples, corresponding to 17 without cellular rejection processes and 11 associated with cellular rejection processes, as based on biopsy analyses. The leave-one-out-cross validation procedure of a Naïve Bayes model enabled the prediction of cellular rejection processes with high sensitivity and specificity (AUC > 0.984). The serum proteomic profile was obtained in a high-throughput mode and based on a simple, rapid, and economical procedure, making it suitable for routine analyses and large-scale studies. Consequently, the current method presents a high potential to predict cellular rejection processes translatable to clinical scenarios, and that should continue to be explored.en
dc.description.versionpublishersversion
dc.description.versionpublished
dc.format.extent2002258
dc.identifier.doi10.3390/ijms25073844
dc.identifier.issn1661-6596
dc.identifier.otherPURE: 89127398
dc.identifier.otherPURE UUID: f721b760-54be-4c6d-b777-9351d911aced
dc.identifier.otherScopus: 85190377956
dc.identifier.otherPubMed: 38612654
dc.identifier.urihttp://hdl.handle.net/10362/166547
dc.identifier.urlhttps://www.scopus.com/pages/publications/85190377956
dc.language.isoeng
dc.peerreviewedyes
dc.subjectcellular rejection
dc.subjectFTIR spectroscopy
dc.subjectkidney allograft
dc.subjectproteomic fingerprint
dc.subjectCatalysis
dc.subjectMolecular Biology
dc.subjectSpectroscopy
dc.subjectComputer Science Applications
dc.subjectPhysical and Theoretical Chemistry
dc.subjectOrganic Chemistry
dc.subjectInorganic Chemistry
dc.titlePredicting Cellular Rejection of Renal Allograft Based on the Serum Proteomic Fingerprinten
dc.typejournal article
degois.publication.issue7
degois.publication.titleInternational Journal of Molecular Sciences
degois.publication.volume25
dspace.entity.typePublication
person.familyNameRamalhete
person.familyNameBigotte Vieira
person.familyNameAraújo
person.familyNameVigia
person.familyNameFerreira
person.familyNameCalado
person.givenNameLuís
person.givenNameMiguel
person.givenNameRúben
person.givenNameEmanuel
person.givenNameAnibal
person.givenNameCecília
person.identifier2296066
person.identifier591378
person.identifier1068794
person.identifier130332
person.identifier.ciencia-idDF19-022D-AA10
person.identifier.ciencia-idFF17-2C76-E2CC
person.identifier.ciencia-id9A18-BFDC-ED95
person.identifier.ciencia-idE918-DF3E-1A17
person.identifier.ciencia-id2E10-C387-4982
person.identifier.ciencia-id9418-E320-3177
person.identifier.orcid0000-0002-8911-3380
person.identifier.orcid0000-0003-0528-2716
person.identifier.orcid0000-0002-9369-6486
person.identifier.orcid0000-0002-4525-9062
person.identifier.orcid0000-0002-3300-6033
person.identifier.orcid0000-0002-5264-9755
person.identifier.ridV-4629-2018
person.identifier.ridW-7385-2018
person.identifier.ridE-2102-2014
person.identifier.scopus-author-id57208672678
person.identifier.scopus-author-id57192837006
person.identifier.scopus-author-id7402999494
person.identifier.scopus-author-id6603163260
rcaap.rightsopenAccess
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relation.isAuthorOfPublication38018d29-cdbf-4571-be18-9b06ef2fe3dd
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relation.isAuthorOfPublication.latestForDiscovery38018d29-cdbf-4571-be18-9b06ef2fe3dd

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