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Carotid body, insulin, and metabolic diseases: unraveling the links

2014-10-29Artigo científico Acesso aberto
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dc.contributor.authorConde, Silvia
dc.contributor.authorV Conde, Silvia
dc.contributor.authorSacramento, Joana
dc.contributor.authorGuarino, MP
dc.contributor.authorGonzalez, Constancio
dc.contributor.authorObeso, Ana
dc.contributor.authorDiogo, Lucília
dc.contributor.authorMonteiro, Emília
dc.contributor.authorMonteiro, E.C.
dc.contributor.authorRibeiro, Maria João
dc.contributor.institutionNOVA Medical School|Faculdade de Ciências Médicas (NMS|FCM)
dc.contributor.institutionCentro de Estudos de Doenças Crónicas (CEDOC)
dc.contributor.pblFrontiers
dc.date.accessioned2017-09-21T22:00:50Z
dc.date.available2017-09-21T22:00:50Z
dc.date.issued2014-10-29
dc.descriptionThis work was supported by the Portuguese Foundation for Science and Technology [Grants EXPL/NEU-SCC/2183/2013] and by the L'Oreal/FCT/UNESCO Medals of Honor for Women in Science 2009 (to Silvia V. Conde) and by Spanish Ministry of Economy and Competitiveness [Grant BFU2012-37459 to Constancio Gonzalez] and by Spanish Ministry of Health-Institute Carlos III [CIBERES to Constancio Gonzalez].
dc.description.abstractThe carotid bodies (CB) are peripheral chemoreceptors that sense changes in arterial blood O-2, CO2, and pH levels. Hypoxia, hypercapnia, and acidosis activate the CB, which respond by increasing the action potential frequency in their sensory nerve, the carotid sinus nerve (CSN). CSN activity is integrated in the brain stem to induce a panoply of cardiorespiratory reflexes aimed, primarily, to normalize the altered blood gases, via hyperventilation, and to regulate blood pressure and cardiac performance, via sympathetic nervous system (SNS) activation. Besides its role in the cardiorespiratory control the CB has been proposed as a metabolic sensor implicated in the control of energy homeostasis and, more recently, in the regulation of whole body insulin sensitivity. Hypercaloric diets cause CB overactivation in rats, which seems to be at the origin of the development of insulin resistance and hypertension, core features of metabolic syndrome and type 2 diabetes. Consistent with this notion, CB sensory denervation prevents metabolic and hemodynamic alterations in hypercaloric feed animal. Obstructive sleep apnea (OSA) is another chronic disorder characterized by increased CB activity and intimately related with several metabolic and cardiovascular abnormalities. In this manuscript we review in a concise manner the putative pathways linking CB chemoreceptors deregulation with the pathogenesis of insulin resistance and arterial hypertension. Also, the link between chronic intermittent hypoxia (CIH) and insulin resistance is discussed. Then, a final section is devoted to debate strategies to reduce CB activity and its use for prevention and therapeutics of metabolic diseases with an emphasis on new exciting research in the modulation of bioelectronic signals, likely to be central in the future.en
dc.description.versionpublishersversion
dc.description.versionpublished
dc.format.extent14
dc.format.extent1447855
dc.identifier.doi10.3389/fphys.2014.00418
dc.identifier.issn1664-042X
dc.identifier.otherPURE: 319814
dc.identifier.otherPURE UUID: 200fbb01-5de3-4cec-b8a5-a0920a93f981
dc.identifier.otherresearchoutputwizard: 47057
dc.identifier.otherPubMed: 25400585
dc.identifier.otherWOS: 000347183600001
dc.identifier.otherScopus: 84908396381
dc.identifier.otherORCID: /0000-0002-5920-5700/work/111135898
dc.identifier.urihttp://hdl.handle.net/10362/23493
dc.language.isoeng
dc.peerreviewedyes
dc.relationinfo:eu-repo/grantAgreement/FCT/3599-PPCDT/135208/PT
dc.subjectCHRONIC CAFFEINE INTAKE
dc.subjectLOW-GLUCOSE
dc.subjectHEART HEALTH
dc.subjectcarotid body
dc.subjectOBESITY-RELATED HYPERTENSION
dc.subjectSYMPATHETIC-NERVOUS-SYSTEM
dc.subjectTYPE-2 DIABETES-MELLITUS
dc.subjectCHRONIC INTERMITTENT HYPOXIA
dc.subjectinsulin resistance
dc.subjectOBSTRUCTIVE SLEEP-APNEA
dc.subjectPOSITIVE AIRWAY PRESSURE
dc.subjectobstructive sleep apnea
dc.subjectBLOOD-PRESSURE
dc.subjectchronic intermittent hypoxia
dc.subjectmetabolic dysfunction
dc.subjectcarotid body
dc.subjectchronic intermittent hypoxia
dc.subjectinsulin resistance
dc.subjectmetabolic dysfunction
dc.subjectobstructive sleep apnea
dc.subjectQP Physiology
dc.subjectPhysiology (medical)
dc.subjectSDG 3 - Good Health and Well-being
dc.titleCarotid body, insulin, and metabolic diseases: unraveling the linksen
dc.typejournal article
degois.publication.firstPage
degois.publication.issueNA
degois.publication.lastPage
degois.publication.titleFrontiers in Physiology
degois.publication.volume5
dspace.entity.typePublication
oaire.awardNumber135208
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/3599-PPCDT/135208/PT
oaire.fundingStream3599-PPCDT
person.familyNameVilares Conde
person.familyNameMonteiro
person.givenNameSilvia
person.givenNameEmília Carreira
person.identifier154176
person.identifier.ciencia-id561E-CF29-600A
person.identifier.ciencia-id5918-54A6-FAA0
person.identifier.orcid0000-0002-5920-5700
person.identifier.orcid0000-0002-0570-0765
person.identifier.scopus-author-id7004283202
person.identifier.scopus-author-id7102113853
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.nameFundação para a Ciência e a Tecnologia
rcaap.rightsopenAccess
relation.isAuthorOfPublication898e99d8-61a5-44bc-878a-5e1ac44ca37c
relation.isAuthorOfPublication631292a4-58bc-4ec4-97ee-1143e44df2c0
relation.isAuthorOfPublication.latestForDiscovery898e99d8-61a5-44bc-878a-5e1ac44ca37c
relation.isProjectOfPublication02544973-be2d-4fa0-8f3c-be82612c2712
relation.isProjectOfPublication.latestForDiscovery02544973-be2d-4fa0-8f3c-be82612c2712

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