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Cytotoxicity profiling of choline chloride-based natural deep eutectic solvents

2023-01-25Artigo científico Acesso aberto
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dc.contributor.authorPopović, Boris M.
dc.contributor.authorGligorijević, Nevenka
dc.contributor.authorAranđelović, Sandra
dc.contributor.authorMacedo, Ana Catarina
dc.contributor.authorJurić, Tatjana
dc.contributor.authorUka, Denis
dc.contributor.authorMocko-Blažek, Karolina
dc.contributor.authorSerra, Ana Teresa
dc.contributor.institutionInstituto de Tecnologia Química e Biológica António Xavier (ITQB)
dc.contributor.pblRSC - Royal Society of Chemistry
dc.date.accessioned2023-09-30T22:19:32Z
dc.date.available2023-09-30T22:19:32Z
dc.date.issued2023-01-25
dc.descriptiongrant no. 7731993, Active Pharmaceutical Ingredient Deep Eutectic Solvents as Novel Therapeutic Agents and Food Supplements – APIDES, and the Ministry of Education, Science and Technological Development of the Republic of Serbia, grant no. 451-03-68/2022-14/200117 and grant no. 451-03-68/2022-14/200043. Publisher Copyright: © 2023 The Royal Society of Chemistry.
dc.description.abstractThis study aims to examine in detail for the first time the cytotoxic profile of twelve choline chloride-based deep eutectic solvents (NADES) against HT-29, Caco-2, MCF-7, and MRC-5 cell lines. All NADES systems were synthesized by microwave synthesis using choline chloride as a hydrogen bond acceptor (HBA) and selected sugars, alcohols, organic acids, and urea as hydrogen bond donors (HBD) with the addition of 20% water (w/w) to all systems. It was observed that the cytotoxic effect predominantly depended on the structure of HBD. Acidic systems, where HBDs were organic acids showed the highest cytotoxic effects in all investigated cell lines. The cytotoxicity depended mostly on the concentration of the NADES system in the cell medium as well as on the chemical constitution of the investigated systems. The highest cytotoxic effects showed acidic systems, especially to the HT-29 cell line. The EC50 value for the citric acid-based system was 3.91 mg mL−1 for the HT-29 cell line which was the most vulnerable to acidic NADES systems.en
dc.description.versionpublishersversion
dc.description.versionpublished
dc.format.extent8
dc.format.extent7220811
dc.identifier.doi10.1039/d2ra07488e
dc.identifier.issn2046-2069
dc.identifier.otherPURE: 72431293
dc.identifier.otherPURE UUID: c3642a1e-86a3-49b3-aa44-c2e8ffbdd2f3
dc.identifier.otherScopus: 85147246277
dc.identifier.urihttp://hdl.handle.net/10362/158532
dc.identifier.urlhttps://www.scopus.com/pages/publications/85147246277
dc.language.isoeng
dc.peerreviewedyes
dc.relationFunding Information: This research was financially supported by the Science Fund of the Republic of Serbia,
dc.subjectGeneral Chemistry
dc.subjectGeneral Chemical Engineering
dc.titleCytotoxicity profiling of choline chloride-based natural deep eutectic solventsen
dc.typejournal article
degois.publication.firstPage3520
degois.publication.issue6
degois.publication.lastPage3527
degois.publication.titleRSC Advances
degois.publication.volume13
dspace.entity.typePublication
rcaap.rightsopenAccess

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