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Platelet transfusions and thrombocytopenia in intensive care units

2022-10Artigo científico Acesso aberto
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dc.contributor.authorAnthon, Carl Thomas
dc.contributor.authorPène, Frédéric
dc.contributor.authorPerner, Anders
dc.contributor.authorAzoulay, Elie
dc.contributor.authorPuxty, Kathryn
dc.contributor.authorVan De Louw, Andry
dc.contributor.authorBarratt-Due, Andreas
dc.contributor.authorChawla, Sanjay
dc.contributor.authorCastro, Pedro
dc.contributor.authorPovoa, Pedro
dc.contributor.authorPovoa, Pedro
dc.contributor.authorCoelho, Luis
dc.contributor.authorMetaxa, Victoria
dc.contributor.authorMunshi, Laveena
dc.contributor.authorKochanek, Matthias
dc.contributor.authorLiebregts, Tobias
dc.contributor.authorKander, Thomas
dc.contributor.authorHästbacka, Johanna
dc.contributor.authorMøller, Morten Hylander
dc.contributor.authorRussell, Lene
dc.contributor.institutionNOVA Medical School|Faculdade de Ciências Médicas (NMS|FCM)
dc.contributor.institutionComprehensive Health Research Centre (CHRC) - pólo NMS
dc.contributor.pblBlackwell Munksgaard
dc.date.accessioned2022-09-19T22:23:39Z
dc.date.available2022-09-19T22:23:39Z
dc.date.issued2022-10
dc.descriptionFunding Information: Ehrenreich's Foundation; Research Council of Rigshospitalet; The Memorial Sloan Kettering Cancer Center part of the study is supported by the Core Grant, Grant/Award Number: P30CA008748; Department of Anesthesiology & Critical Care Medicine, Memorial Sloan Kettering Cancer Center, New York, NY, USA Funding information Funding Information: The Department of Intensive Care 4131 at Rigshospitalet (CTA, MHM, AP, LR) has received funding for other projects from the Novo Nordisk Foundation, Pfizer, Ferring Pharmaceuticals and Fresenius Kabi and conducts contract research for AM‐Pharma. PP had received honoraria for lectures and participation in advisory boards from Merck Sharp & Dohme, Sanofi, Gilead and Pfizer. Funding Information: CTA has received funding from the Ehrenreich's Foundation. CTA and LR have received funding from the Research Council of Rigshospitalet. The Memorial Sloan Kettering Cancer Center part of the study is supported by the Core Grant (P30 CA008748) and the Department of Anesthesiology & Critical Care Medicine, Memorial Sloan Kettering Cancer Center, New York, NY. The funders do not have any influence on the study design, conduct or reporting. Publisher Copyright: © 2022 The Authors. Acta Anaesthesiologica Scandinavica published by John Wiley & Sons Ltd on behalf of Acta Anaesthesiologica Scandinavica Foundation.
dc.description.abstractIntroduction: Thrombocytopenia is frequent in intensive care unit (ICU) patients and has been associated with worse outcome. Platelet transfusions are often used in the management of ICU patients with severe thrombocytopenia. However, the reported frequencies of thrombocytopenia and platelet transfusion practices in the ICU vary considerably. Therefore, we aim to provide contemporary epidemiological data on thrombocytopenia and platelet transfusion practices in the ICU. Methods: We will conduct an international inception cohort, including at least 1000 acutely admitted adult ICU patients. Routinely available data will be collected at baseline (ICU admission), and daily during ICU stay up to a maximum of 90 days. The primary outcome will be the number of patients with thrombocytopenia (a recorded platelet count < 150 × 109/L) at baseline and/or during ICU stay. Secondary outcomes include mortality, days alive and out of hospital, days alive without life-support, the number of patients with at least one bleeding episode, at least one thromboembolic event and at least one platelet transfusion in the ICU, the number of platelet transfusions and the indications for transfusion. The primary and secondary outcomes will be presented descriptively. In addition, we will assess risk factors for developing thrombocytopenia during ICU stay and the association between thrombocytopenia at baseline and 90-day mortality using logistic regression analyses. Conclusion: The outlined international PLOT-ICU cohort study will provide contemporary epidemiological data on the burden and clinical significance of thrombocytopenia in adult ICU patients and describe the current platelet transfusion practice.en
dc.description.versionpublishersversion
dc.description.versionpublished
dc.format.extent754762
dc.identifier.doi10.1111/aas.14124
dc.identifier.issn0001-5172
dc.identifier.otherPURE: 46486211
dc.identifier.otherPURE UUID: 13024371-dff5-4181-83af-d3dd7811699b
dc.identifier.otherScopus: 85136980553
dc.identifier.urihttp://hdl.handle.net/10362/143838
dc.identifier.urlhttps://www.scopus.com/pages/publications/85136980553
dc.language.isoeng
dc.peerreviewedyes
dc.subjectintensive care unit
dc.subjectplatelet transfusion
dc.subjectthrombocytopenia
dc.subjectAnesthesiology and Pain Medicine
dc.titlePlatelet transfusions and thrombocytopenia in intensive care unitsen
dc.title.subtitleProtocol for an international inception cohort study (PLOT-ICU)en
dc.typejournal article
degois.publication.firstPage1146
degois.publication.issue9
degois.publication.lastPage1155
degois.publication.titleActa Anaesthesiologica Scandinavica
degois.publication.volume66
dspace.entity.typePublication
person.familyNamePovoa
person.givenNamePedro
person.identifier.ciencia-id0C16-5CF9-9238
person.identifier.orcid0000-0002-7069-7304
person.identifier.scopus-author-id6602772147
rcaap.rightsopenAccess
relation.isAuthorOfPublication04ec38ba-be1e-46e5-8007-0e65a557d0f4
relation.isAuthorOfPublication.latestForDiscovery04ec38ba-be1e-46e5-8007-0e65a557d0f4

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