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The Characteristics and Laboratory Findings of SARS-CoV-2 Infected Patients during the First Three COVID-19 Waves in Portugal-A Retrospective Single-Center Study

2024-01Artigo científico Acesso aberto
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dc.contributor.authorVon Rekowski, Cristiana P
dc.contributor.authorFonseca, Tiago A H
dc.contributor.authorAraújo, Rúben
dc.contributor.authorBrás-Geraldes, Carlos
dc.contributor.authorCalado, Cecília R C
dc.contributor.authorCalado, Cecília
dc.contributor.authorBento, Luís
dc.contributor.authorBento, Luís
dc.contributor.authorPinto, Iola
dc.contributor.institutionNOVA Medical School|Faculdade de Ciências Médicas (NMS|FCM)
dc.contributor.institutionComprehensive Health Research Centre (CHRC) - pólo NMS
dc.contributor.institutionCMA - Centro de Matemática e Aplicações
dc.contributor.pblMDPI - Multidisciplinary Digital Publishing Institute
dc.date.accessioned2024-01-30T01:43:16Z
dc.date.available2024-01-30T01:43:16Z
dc.date.issued2024-01
dc.description.abstractBackground and Objectives: Given the wide spectrum of clinical and laboratory manifestations of the coronavirus disease 2019 (COVID-19), it is imperative to identify potential contributing factors to patients' outcomes. However, a limited number of studies have assessed how the different waves affected the progression of the disease, more so in Portugal. Therefore, our main purpose was to study the clinical and laboratory patterns of COVID-19 in an unvaccinated population admitted to the intensive care unit, identifying characteristics associated with death, in each of the first three waves of the pandemic. Materials and Methods: This study included 337 COVID-19 patients admitted to the intensive care unit of a single-center hospital in Lisbon, Portugal, between March 2020 and March 2021. Comparisons were made between three COVID-19 waves, in the second (n = 325) and seventh (n = 216) days after admission, and between discharged and deceased patients. Results: Deceased patients were considerably older (p = 0.021) and needed greater ventilatory assistance (p = 0.023), especially in the first wave. Differences between discharged and deceased patients' biomarkers were minimal in the first wave, on both analyzed days. In the second wave significant differences emerged in troponins, lactate dehydrogenase, procalcitonin, C-reactive protein, and white blood cell subpopulations, as well as platelet-to-lymphocyte and neutrophil-to-lymphocyte ratios (all p < 0.05). Furthermore, in the third wave, platelets and D-dimers were also significantly different between patients' groups (all p < 0.05). From the second to the seventh days, troponins and lactate dehydrogenase showed significant decreases, mainly for discharged patients, while platelet counts increased (all p < 0.01). Lymphocytes significantly increased in discharged patients (all p < 0.05), while white blood cells rose in the second (all p < 0.001) and third (all p < 0.05) waves among deceased patients. Conclusions: This study yields insights into COVID-19 patients' characteristics and mortality-associated biomarkers during Portugal's first three COVID-19 waves, highlighting the importance of considering wave variations in future research due to potential significant outcome differences.en
dc.description.versionpublishersversion
dc.description.versionpublished
dc.format.extent6758280
dc.identifier.doi10.3390/medicina60010059
dc.identifier.issn1010-660X
dc.identifier.otherPURE: 82240130
dc.identifier.otherPURE UUID: 4e81b5f3-13ff-464a-ae72-d0478e602227
dc.identifier.otherPubMed: 38256320
dc.identifier.otherORCID: /0000-0002-1551-6531/work/151887801
dc.identifier.otherScopus: 85183149257
dc.identifier.urihttp://hdl.handle.net/10362/162859
dc.language.isoeng
dc.peerreviewedyes
dc.subjectcoronavirus disease 2019
dc.subjectintensive care unit
dc.subjectmortality
dc.subjectblood biomarkers
dc.subjectcoronavirus disease 2019 waves
dc.titleThe Characteristics and Laboratory Findings of SARS-CoV-2 Infected Patients during the First Three COVID-19 Waves in Portugal-A Retrospective Single-Center Studyen
dc.typejournal article
degois.publication.issue1
degois.publication.titleMedicina (Kaunas, Lithuania)
degois.publication.volume60
dspace.entity.typePublication
person.familyNameCalado
person.familyNameBento
person.givenNameCecília
person.givenNameLuís
person.identifier130332
person.identifier.ciencia-id9418-E320-3177
person.identifier.ciencia-idE711-FA12-4784
person.identifier.orcid0000-0002-5264-9755
person.identifier.orcid0000-0002-0260-003X
person.identifier.ridE-2102-2014
person.identifier.ridL-6623-2018
person.identifier.scopus-author-id6603163260
rcaap.rightsopenAccess
relation.isAuthorOfPublicationc7f59ff7-65ff-44b3-b444-093114c0a2e4
relation.isAuthorOfPublicatione4d7016b-9d39-48d1-b834-05db9516445d
relation.isAuthorOfPublication.latestForDiscoveryc7f59ff7-65ff-44b3-b444-093114c0a2e4

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