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HBM4EU Chromates Study

2022-04-18Artigo científico Acesso aberto
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dc.contributor.authorKozłowska, Lucyna
dc.contributor.authorSantonen, Tiina
dc.contributor.authorDuca, Radu Corneliu
dc.contributor.authorGodderis, Lode
dc.contributor.authorJagiello, Karolina
dc.contributor.authorJanasik, Beata
dc.contributor.authorVan Nieuwenhuyse, An
dc.contributor.authorPoels, Katrien
dc.contributor.authorPuzyn, Tomasz
dc.contributor.authorScheepers, Paul T J
dc.contributor.authorSijko, Monika
dc.contributor.authorSilva, Maria João
dc.contributor.authorSosnowska, Anita
dc.contributor.authorViegas, Susana
dc.contributor.authorVerdonck, Jelle
dc.contributor.authorWąsowicz, Wojciech
dc.contributor.authorOn Behalf Of Hbm Eu Chromates Study Team
dc.contributor.authorOn Behalf Of Statistical Team
dc.contributor.institutionNOVA Medical School|Faculdade de Ciências Médicas (NMS|FCM)
dc.contributor.institutionCentre for Toxicogenomics and Human Health (ToxOmics)
dc.contributor.institutionComprehensive Health Research Centre (CHRC) - Pólo ENSP
dc.contributor.institutionEscola Nacional de Saúde Pública (ENSP)
dc.contributor.institutionCentro de Investigação em Saúde Pública (CISP/PHRC)
dc.contributor.pblMDPI - Multidisciplinary Digital Publishing Institute
dc.date.accessioned2022-05-12T22:35:10Z
dc.date.available2022-05-12T22:35:10Z
dc.date.issued2022-04-18
dc.description.abstractExposure to hexavalent chromium Cr(VI) may occur in several occupational activities, placing workers in many industries at risk for potential related health outcomes. Untargeted metabolomics was applied to investigate changes in metabolic pathways in response to Cr(VI) exposure. We obtained our data from a study population of 220 male workers with exposure to Cr(VI) and 102 male controls from Belgium, Finland, Poland, Portugal and the Netherlands within the HBM4EU Chromates Study. Urinary metabolite profiles were determined using liquid chromatography mass spectrometry, and differences between post-shift exposed workers and controls were analyzed using principal component analysis. Based on the first two principal components, we observed clustering by industrial chromate application, such as welding, chrome plating, and surface treatment, distinct from controls and not explained by smoking status or alcohol use. The changes in the abundancy of excreted metabolites observed in workers reflect fatty acid and monoamine neurotransmitter metabolism, oxidative modifications of amino acid residues, the excessive formation of abnormal amino acid metabolites and changes in steroid and thyrotropin-releasing hormones. The observed responses could also have resulted from work-related factors other than Cr(VI). Further targeted metabolomics studies are needed to better understand the observed modifications and further explore the suitability of urinary metabolites as early indicators of adverse effects associated with exposure to Cr(VI).en
dc.description.versionpublishersversion
dc.description.versionpublished
dc.format.extent5135931
dc.identifier.doi10.3390/metabo12040362
dc.identifier.issn2218-1989
dc.identifier.otherPURE: 43865937
dc.identifier.otherPURE UUID: f1fd4409-0f8a-4fe1-8977-8ae02d72642c
dc.identifier.otherPubMed: 35448548
dc.identifier.otherPubMedCentral: PMC9032989
dc.identifier.otherWOS: 000786041700001
dc.identifier.otherScopus: 85129227686
dc.identifier.urihttp://hdl.handle.net/10362/137844
dc.language.isoeng
dc.peerreviewedyes
dc.subjectSDG 3 - Good Health and Well-being
dc.titleHBM4EU Chromates Studyen
dc.title.subtitleurinary metabolomics study of workers exposed to hexavalent chromiumen
dc.typejournal article
degois.publication.issue4
degois.publication.titleMetabolites
degois.publication.volume12
dspace.entity.typePublication
rcaap.rightsopenAccess

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