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Influence of human milk on very preterms’ gut microbiota and alkaline phosphatase activity

2021-05-06Artigo científico Acesso aberto
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dc.contributor.authorMorais, Juliana
dc.contributor.authorMarques, Cláudia
dc.contributor.authorFaria, Ana
dc.contributor.authorTeixeira, Diana
dc.contributor.authorBarreiros-Mota, Inês
dc.contributor.authorDurão, Catarina
dc.contributor.authorAraújo, João
dc.contributor.authorIsmael, Shámila
dc.contributor.authorBrito, Sara
dc.contributor.authorCardoso, Manuela
dc.contributor.authorMacedo, Israel
dc.contributor.authorPereira, Esmeralda
dc.contributor.authorTomé, Teresa
dc.contributor.authorCalhau, Conceição
dc.contributor.authorCalhau, Conceição
dc.contributor.institutionNOVA Medical School|Faculdade de Ciências Médicas (NMS|FCM)
dc.contributor.institutionComprehensive Health Research Centre (CHRC) - pólo NMS
dc.contributor.institutionCentro de Estudos de Doenças Crónicas (CEDOC)
dc.contributor.institutionCentro de Investigação em Tecnologias e Serviços de Saúde (CINTESIS)
dc.contributor.pblMDPI AG
dc.date.accessioned2021-07-05T22:18:00Z
dc.date.available2021-07-05T22:18:00Z
dc.date.issued2021-05-06
dc.descriptionFunding: This study was supported by Milupa DN-ELN 2017 grant from the Portuguese Neonatal Society, by ERDF through the operation POCI-01-0145-ERDF-007746 funded by the Programa Operacional Competitividade e Internacionalização–COMPETE2020, and by National Funds through FCT– Fundação para a Ciência e a Tecnologia within CINTESIS, R&D Unit (reference UID/IC/4255/2013).
dc.description.abstractThe FEEDMI Study (NCT03663556) evaluated the influence of infant feeding (mother’s own milk (MOM), donor human milk (DHM) and formula) on the fecal microbiota composition and alkaline phosphatase (ALP) activity in extremely and very preterm infants (≤32 gestational weeks). In this observational study, preterm infants were recruited within the first 24 h after birth. Meconium and fecal samples were collected at four time points (between the 2nd and the 26th postnatal days. Fecal microbiota was analyzed by RT-PCR and by 16S rRNA sequencing. Fecal ALP activity, a proposed specific biomarker of necrotizing enterocolitis (NEC), was evaluated by spectrophotometry at the 26th postnatal day. A total of 389 fecal samples were analyzed from 117 very preterm neonates. Human milk was positively associated with beneficial bacteria, such as Bifidobacterium, Bacteroides ovatus, and Akkermancia muciniphila, as well as bacterial richness. Neonates fed with human milk during the first week of life had increased Bifidobacterium content and fecal ALP activity on the 26th postnatal day. These findings point out the importance of MOM and DHM in the establishment of fecal microbiota on neonates prematurely delivered. Moreover, these results suggest an ALP pathway by which human milk may protect against NEC.en
dc.description.versionpublishersversion
dc.description.versionpublished
dc.format.extent2340841
dc.identifier.doi10.3390/nu13051564
dc.identifier.issn1422-8599
dc.identifier.otherPURE: 29762415
dc.identifier.otherPURE UUID: 1174a1e4-b3ae-4381-b9a3-9090c564a0bb
dc.identifier.otherScopus: 85105161783
dc.identifier.otherPubMed: 34066473
dc.identifier.otherWOS: 000662393900001
dc.identifier.urihttp://hdl.handle.net/10362/120532
dc.identifier.urlhttps://www.scopus.com/pages/publications/85105161783
dc.language.isoeng
dc.peerreviewedyes
dc.subjectAlkaline phosphatase
dc.subjectDonor human milk
dc.subjectFormula
dc.subjectGut microbiota
dc.subjectMother’s own milk
dc.subjectVery preterm neonates
dc.subjectFood Science
dc.subjectNutrition and Dietetics
dc.titleInfluence of human milk on very preterms’ gut microbiota and alkaline phosphatase activityen
dc.typejournal article
degois.publication.issue5
degois.publication.titleNutrients
degois.publication.volume13
dspace.entity.typePublication
person.familyNameCalhau
person.givenNameConceição
person.identifier.ciencia-id2110-0420-1717
person.identifier.orcid0000-0001-9567-3379
person.identifier.scopus-author-id6701578877
rcaap.rightsopenAccess
relation.isAuthorOfPublication32b016c8-810a-40be-b9ee-ddfb07668a78
relation.isAuthorOfPublication.latestForDiscovery32b016c8-810a-40be-b9ee-ddfb07668a78

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