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In-hospital adverse drug events

2020-01-01Artigo científico Acesso aberto
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dc.contributor.authorVitorino, Mavilde
dc.contributor.authorAguiar, Pedro
dc.contributor.authorSousa, Paulo
dc.contributor.institutionEscola Nacional de Saúde Pública (ENSP)
dc.contributor.institutionCentro de Investigação em Saúde Pública (CISP/PHRC)
dc.contributor.pblEscola Nacional de Saúde Pública Sergio Arouca | Fundação Oswaldo Cruz
dc.date.accessioned2020-07-27T22:45:31Z
dc.date.available2020-07-27T22:45:31Z
dc.date.issued2020-01-01
dc.description.abstractThe objectives of this study were to analyze in-hospital adverse drug events (ADEs) in Portuguese public hospitals, and their association with mortality and the duration of hospitalization. We analyzed an administrative database containing the registration of all hospitalizations occurring in Portuguese public hospitals in 2013-2015. ADEs were identified using the codes E850-858.9 and E930-949.9 from ICD-9-CM. We identified all episodes with registration of in-hospital ADE and we compared them with a random sample of an equal number of episodes with no events recorded. A total of 3,041,443 cases were analyzed, 60,521 presented at least one ADE from which 17,213 occurred in hospital context. The most frequent drug classes associated with ADE were the antineoplastics/immunosuppressant drugs, antibiotics and steroids. Patient characteristics associated with a greater occurrence of in-hospital ADEs (all with p < 0.001) were medical admissions (OR = 1.29), the diagnosis - myeloid leukaemia (OR = 18.63), nephrotic syndrome (OR = 15.75), pneumonia (OR = 1.33) -, a higher number of secondary diagnoses (OR = 1.27), and increased duration of hospital stay (OR = 1.06). Hospitalizations with records of in-hospital ADEs presented a significantly higher mortality (9.6% vs. 4.5) and duration of hospitalization (22.6 vs. 6.4 days). ADEs were shown to be directly associated with an increase in the duration of hospital stay of 8.18 days. This study adds some interesting insights related to the most frequent drug classes and patient characteristics that can influence the frequency of ADEs in Portuguese public hospitals and also the burden of injury resulting from them.en
dc.description.versionpublishersversion
dc.description.versionpublished
dc.format.extent609284
dc.identifier.doi10.1590/0102-311x00056519
dc.identifier.issn0102-311X
dc.identifier.otherPURE: 19221967
dc.identifier.otherPURE UUID: 959b0cb6-929e-400f-83d9-f48061046e00
dc.identifier.otherScopus: 85082008601
dc.identifier.otherPubMed: 32187293
dc.identifier.otherWOS: 000521572800001
dc.identifier.otherORCID: /0000-0001-9502-6075/work/130929478
dc.identifier.otherORCID: /0000-0002-0074-7732/work/139077036
dc.identifier.urihttp://hdl.handle.net/10362/101583
dc.identifier.urlhttps://www.scopus.com/pages/publications/85082008601
dc.language.isomul
dc.peerreviewedyes
dc.subjectAdverse event
dc.subjectHospitalization
dc.subjectInternational classification of diseases
dc.subjectPublic Health, Environmental and Occupational Health
dc.subjectSDG 3 - Good Health and Well-being
dc.titleIn-hospital adverse drug events
dc.title.alternativeEventos adversos a medicamentos durante a internação hospitalaranálise de tendência em hospitais públicos de Portugalen
dc.title.subtitleanalysis of trend in Portuguese public hospitals
dc.typejournal article
degois.publication.issue3
degois.publication.titleCadernos de Saúde Pública
degois.publication.volume36
dspace.entity.typePublication
rcaap.rightsopenAccess

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