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HIV-1 Infection in Cyprus, the Eastern Mediterranean European Frontier

2018-12-01Artigo científico Acesso aberto
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dc.contributor.authorPineda-Peña, Andrea Clemencia
dc.contributor.authorTheys, Kristof
dc.contributor.authorStylianou, Dora C.
dc.contributor.authorDemetriades, Ioannis
dc.contributor.authorPuchhammer, Elisabeth
dc.contributor.authorVandamme, Anne Mieke
dc.contributor.authorAleksiev, Ivailo
dc.contributor.authorLepej, Snjezana Zidovec
dc.contributor.authorLinka, Marek
dc.contributor.authorFonager, Jannik
dc.contributor.authorLiitsola, Kirsi
dc.contributor.authorKaiser, Rolf
dc.contributor.authorHamouda, Osamah
dc.contributor.authorParaskevis, Dimitrios
dc.contributor.authorCoughlan, Suzie
dc.contributor.authorGrossman, Zehava
dc.contributor.authorMor, Orna
dc.contributor.authorZazzi, Maurizio
dc.contributor.authorGriskevicius, Algirdas
dc.contributor.authorLipnickiene, Vilnele
dc.contributor.authorDevaux, Carole
dc.contributor.authorBoucher, Charles
dc.contributor.authorHofstra, Marije
dc.contributor.authorWensing, Annemarie
dc.contributor.authorBakken-Kran, Anne Marte
dc.contributor.authorHorban, Andrzej
dc.contributor.authorCamacho, Ricardo
dc.contributor.authorParaschiv, Simona
dc.contributor.authorOtelea, Dan
dc.contributor.authorStanojevic, Maja
dc.contributor.authorStanekova, Danika
dc.contributor.authorPoljak, Mario
dc.contributor.authorGarcia, Federico
dc.contributor.authorParedes, Roger
dc.contributor.authorAlbert, Jan
dc.contributor.authorAbecasis, Ana B.
dc.contributor.authorKostrikis, Leondios G.
dc.contributor.institutionTB, HIV and opportunistic diseases and pathogens (THOP)
dc.contributor.institutionInstituto de Higiene e Medicina Tropical (IHMT)
dc.contributor.institutionGlobal Health and Tropical Medicine (GHTM)
dc.contributor.pblNature Publishing Group
dc.date.accessioned2021-05-02T22:37:19Z
dc.date.available2021-05-02T22:37:19Z
dc.date.issued2018-12-01
dc.description.abstractSince HIV-1 treatment is increasingly considered an effective preventionstrategy, it is important to study local HIV-1 epidemics to formulate tailored preventionpolicies. The prevalence of HIV-1 in Cyprus was historically low until 2005. To investigatethe shift in epidemiological trends, we studied the transmission dynamics of HIV-1 in Cyprususing a densely sampled Cypriot HIV-1 transmission cohort that included 85 percent ofHIV-1-infected individuals linked to clinical care between 1986 and 2012 based on detailedclinical, epidemiological, behavioral and HIV-1 genetic information. Subtyping andtransmission cluster reconstruction were performed using maximum likelihood and Bayesianmethods, and the transmission chain network was linked to the clinical, epidemiological andbehavioral data. The results reveal that for the main HIV-1 subtype A1 and B sub-epidemics,young and drug-naïve HIV-1-infected individuals in Cyprus are driving the dynamics of thelocal HIV-1 epidemic. The results of this study provide a better understanding of thedynamics of the HIV-1 infection in Cyprus, which may impact the development of preventionstrategies. Furthermore, this methodology for analyzing densely sampled transmissiondynamics is applicable to other geographic regions to implement effective HIV-1 preventionstrategies in local settings.en
dc.description.versionpublishersversion
dc.description.versionpublished
dc.format.extent3704066
dc.identifier.doi10.1038/s41598-017-19080-5
dc.identifier.issn2045-2322
dc.identifier.otherPURE: 3956806
dc.identifier.otherPURE UUID: b26edd6d-06eb-489a-9f23-f0fe37fc8c1d
dc.identifier.otherScopus: 85041118980
dc.identifier.otherPubMed: 29374182
dc.identifier.otherPubMedCentral: 5786036
dc.identifier.urihttp://hdl.handle.net/10362/116684
dc.identifier.urlhttps://www.scopus.com/pages/publications/85041118980
dc.language.isoeng
dc.peerreviewedyes
dc.subjectEpidemiology
dc.subjectVirology
dc.subjectBiochemistry, Genetics and Molecular Biology (miscellaneous)
dc.subjectSDG 3 - Good Health and Well-being
dc.titleHIV-1 Infection in Cyprus, the Eastern Mediterranean European Frontieren
dc.title.subtitleA Densely Sampled Transmission Dynamics Analysis from 1986 to 2012en
dc.typejournal article
degois.publication.issue1
degois.publication.titleScientific Reports
degois.publication.volume8
dspace.entity.typePublication
rcaap.rightsopenAccess

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