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Do fatty lesions explain the effect of inflammation on new syndesmophytes in patients with radiographic axial spondyloarthritis? Results from the SIAS cohort and ASSERT trial

2023-07-05Artigo científico Acesso aberto
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dc.contributor.authorStal, Rosalinde
dc.contributor.authorRamiro, Sofia
dc.contributor.authorRamiro, Sofia
dc.contributor.authorVan Der Heijde, Desirée
dc.contributor.authorVan Gaalen, Floris A.
dc.contributor.authorBaraliakos, Xenofon
dc.contributor.authorMachado, Pedro M.
dc.contributor.authorDe Hooge, Manouk
dc.contributor.authorVan Den Berg, Rosaline
dc.contributor.authorReijnierse, Monique
dc.contributor.authorBraun, Juergen
dc.contributor.authorLandewé, Robert
dc.contributor.authorSepriano, Alexandre
dc.contributor.authorSepriano, Alexandre
dc.contributor.institutionNOVA Medical School|Faculdade de Ciências Médicas (NMS|FCM)
dc.contributor.pblBMJ Publishing Group
dc.date.accessioned2024-02-07T00:03:57Z
dc.date.available2024-02-07T00:03:57Z
dc.date.issued2023-07-05
dc.descriptionFunding Information: This work was supported by Reuma Nederland and Novartis. Publisher Copyright: © Author(s) (or their employer(s)) 2023. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ.
dc.description.abstractObjectives To determine how much of the effect of vertebral corner inflammation on development of syndesmophytes is explained by vertebral corner fat deposition. Methods Patients with radiographic axial spondyloarthritis (r-axSpA) from the SIAS (Sensitive Imaging in Ankylosing Spondylitis) cohort and ASSERT (Ankylosing Spondylitis Study for the Evaluation of Recombinant Infliximab Therapy) trial were assessed at T0, T1 (SIAS: 1 year; ASSERT: 24 weeks) and T2 (2 years). Syndesmophytes assessed in each vertebral corner by whole spine low-dose CT (SIAS) or spinal radiographs (ASSERT) at T0 and T2 were considered present if seen by two of two readers. Inflammation (T0) and fat deposition (T0 and T1) on MRI were present if seen by ≥2 of 3 readers (SIAS) or 2 of 2 readers (ASSERT). Vertebral corners showing fat deposition or a syndesmophyte at baseline were ignored. Mediation analysis was applied to determine what proportion of the total effect of inflammation on syndesmophyte formation could be explained via the path of intermediate fat deposition. Results Forty-nine SIAS patients (with 2667 vertebral corners) and 168 ASSERT patients (with 2918 vertebral corners) were analysed. The presence of inflammation at T0 increased the probability of a new syndesmophyte in the same vertebral corner at T2 by 9.3%. Of this total effect, 0.2% (2% (0.2 of 9.3) of the total effect) went via intermediate new fat deposition. In ASSERT, the total effect was 7.3%, of which 0.8% (10% of the total effect) went via new fat deposition. Conclusion In r-axSpA, vertebral corner inflammation may lead to syndesmophyte formation but in a minority of cases via visible fat deposition.en
dc.description.versionpublishersversion
dc.description.versionpublished
dc.format.extent673257
dc.identifier.doi10.1136/rmdopen-2023-003118
dc.identifier.issn2044-6055
dc.identifier.otherPURE: 82857171
dc.identifier.otherPURE UUID: cf64811d-a997-4739-b4c9-9068ab9aefc0
dc.identifier.otherScopus: 85164015348
dc.identifier.otherPubMed: 37407237
dc.identifier.urihttp://hdl.handle.net/10362/163192
dc.identifier.urlhttps://www.scopus.com/pages/publications/85164015348
dc.language.isoeng
dc.peerreviewedyes
dc.subjectInflammation
dc.subjectMagnetic Resonance Imaging
dc.subjectSpondylitis, Ankylosing
dc.subjectRheumatology
dc.subjectImmunology and Allergy
dc.subjectImmunology
dc.titleDo fatty lesions explain the effect of inflammation on new syndesmophytes in patients with radiographic axial spondyloarthritis? Results from the SIAS cohort and ASSERT trialen
dc.typejournal article
degois.publication.issue3
degois.publication.titleRMD Open
degois.publication.volume9
dspace.entity.typePublication
person.familyNameRamiro
person.familyNameSepriano
person.givenNameSofia
person.givenNameAlexandre
person.identifier397398
person.identifier.ciencia-idC513-D4F1-EEC3
person.identifier.ciencia-id5E1B-9976-5CE4
person.identifier.orcid0000-0002-8899-9087
person.identifier.orcid0000-0003-1954-0229
person.identifier.scopus-author-id55266526300
rcaap.rightsopenAccess
relation.isAuthorOfPublication9853406a-2641-440d-a8b1-a516bdb6f32f
relation.isAuthorOfPublicationd87df0c7-841b-4648-a99e-296348e2e286
relation.isAuthorOfPublication.latestForDiscoveryd87df0c7-841b-4648-a99e-296348e2e286

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